RANGRF report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of RANGRF at tissue level.

III. Associated gene sets

GO_2000649Biological processregulation of sodium ion transmembrane transporter activity
GO_0042391Biological processregulation of membrane potential
GO_0098909Biological processregulation of cardiac muscle cell action potential involved in regulation of contraction
GO_0032527Biological processprotein exit from endoplasmic reticulum
GO_0098905Biological processregulation of bundle of His cell action potential
GO_0002027Biological processregulation of heart rate
GO_2000010Biological processpositive regulation of protein localization to cell surface
GO_0003254Biological processregulation of membrane depolarization
GO_0090307Biological processmitotic spindle assembly
GO_1903078Biological processpositive regulation of protein localization to plasma membrane
GO_0060047Biological processheart contraction
GO_1900825Biological processregulation of membrane depolarization during cardiac muscle cell action potential
GO_0006606Biological processprotein import into nucleus
GO_0006888Biological processendoplasmic reticulum to Golgi vesicle-mediated transport
GO_1902305Biological processregulation of sodium ion transmembrane transport
GO_0005886Cellular componentplasma membrane
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005791Cellular componentrough endoplasmic reticulum
GO_0005901Cellular componentcaveola
GO_0014704Cellular componentintercalated disc
GO_0005634Cellular componentnucleus
GO_0005085Molecular functionguanyl-nucleotide exchange factor activity
GO_0031267Molecular functionsmall GTPase binding
GO_0044325Molecular functiontransmembrane transporter binding
GO_0017080Molecular functionsodium channel regulator activity

IV. Literature review

[source]
Gene nameRANGRF
Protein nameRan guanine nucleotide release factor (RanGNRF) (Ran-binding protein MOG1)
SynonymsHSPC236
MDS5
HSPC165
MOG1
RANGNRF
DescriptionFUNCTION: May regulate the intracellular trafficking of RAN . Promotes guanine nucleotide release from RAN and inhibits binding of new GTP by preventing the binding of the RAN guanine nucleotide exchange factor RCC1 . Regulates the levels of GTP-bound RAN in the nucleus, and thereby plays a role in the regulation of RAN-dependent mitotic spindle dynamics . Enhances the expression of SCN5A at the cell membrane in cardiomyocytes . .

AccessionsENST00000439238.3 [Q9HD47-3]
ENST00000580434.5 [Q9HD47-4]
ENST00000407006.8 [Q9HD47-2]
Q9HD47
ENST00000226105.11 [Q9HD47-1]