Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 19 studies | 31% ± 14% | |
glutamatergic neuron | 9 studies | 48% ± 25% | |
microglial cell | 9 studies | 27% ± 7% | |
adipocyte | 9 studies | 29% ± 9% | |
astrocyte | 9 studies | 30% ± 13% | |
macrophage | 8 studies | 31% ± 10% | |
oligodendrocyte | 8 studies | 27% ± 8% | |
epithelial cell | 7 studies | 32% ± 13% | |
fibroblast | 7 studies | 24% ± 9% | |
GABAergic neuron | 7 studies | 45% ± 24% | |
oligodendrocyte precursor cell | 7 studies | 27% ± 10% | |
endothelial cell of lymphatic vessel | 6 studies | 37% ± 13% | |
neuron | 5 studies | 39% ± 19% | |
plasma cell | 5 studies | 34% ± 15% | |
cardiac muscle cell | 5 studies | 36% ± 9% | |
ciliated cell | 5 studies | 21% ± 6% | |
respiratory goblet cell | 5 studies | 26% ± 10% | |
myeloid cell | 5 studies | 24% ± 7% | |
monocyte | 5 studies | 25% ± 6% | |
club cell | 5 studies | 22% ± 6% | |
type I pneumocyte | 5 studies | 21% ± 5% | |
type II pneumocyte | 5 studies | 22% ± 5% | |
smooth muscle cell | 5 studies | 19% ± 4% | |
pericyte | 4 studies | 23% ± 6% | |
dendritic cell | 4 studies | 21% ± 6% | |
mast cell | 4 studies | 21% ± 6% | |
interneuron | 4 studies | 53% ± 22% | |
GABAergic interneuron | 3 studies | 26% ± 5% | |
mesothelial cell | 3 studies | 23% ± 4% | |
endothelial cell of vascular tree | 3 studies | 32% ± 15% | |
hepatocyte | 3 studies | 42% ± 19% | |
retinal pigment epithelial cell | 3 studies | 37% ± 14% | |
abnormal cell | 3 studies | 31% ± 18% | |
B cell | 3 studies | 24% ± 7% | |
T cell | 3 studies | 17% ± 1% | |
alveolar macrophage | 3 studies | 36% ± 9% | |
lymphocyte | 3 studies | 26% ± 5% | |
basal cell | 3 studies | 31% ± 17% | |
goblet cell | 3 studies | 49% ± 25% | |
transit amplifying cell | 3 studies | 31% ± 20% | |
mucus secreting cell | 3 studies | 27% ± 7% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 3857.29 | 1445 / 1445 | 100% | 50.57 | 183 / 183 |
stomach | 100% | 4496.42 | 359 / 359 | 100% | 48.71 | 285 / 286 |
intestine | 100% | 4592.33 | 966 / 966 | 100% | 43.13 | 525 / 527 |
lung | 100% | 3676.88 | 577 / 578 | 99% | 29.77 | 1148 / 1155 |
breast | 100% | 4846.49 | 459 / 459 | 99% | 56.54 | 1103 / 1118 |
pancreas | 100% | 3762.90 | 328 / 328 | 97% | 26.40 | 173 / 178 |
bladder | 100% | 4209.86 | 21 / 21 | 97% | 29.23 | 489 / 504 |
thymus | 100% | 7572.55 | 653 / 653 | 97% | 42.88 | 584 / 605 |
ovary | 100% | 3336.66 | 180 / 180 | 96% | 19.51 | 414 / 430 |
prostate | 100% | 3623.47 | 245 / 245 | 96% | 30.32 | 482 / 502 |
skin | 100% | 4885.91 | 1809 / 1809 | 96% | 41.66 | 453 / 472 |
kidney | 100% | 3095.92 | 89 / 89 | 95% | 28.02 | 860 / 901 |
uterus | 100% | 3910.08 | 170 / 170 | 94% | 21.56 | 431 / 459 |
brain | 98% | 2638.25 | 2578 / 2642 | 96% | 18.83 | 675 / 705 |
adrenal gland | 100% | 8682.51 | 258 / 258 | 93% | 26.81 | 214 / 230 |
liver | 100% | 2801.25 | 226 / 226 | 88% | 19.65 | 356 / 406 |
adipose | 100% | 3945.94 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 4523.49 | 1335 / 1335 | 0% | 0 | 0 / 0 |
muscle | 100% | 3010.42 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 4106.95 | 241 / 241 | 0% | 0 | 0 / 0 |
heart | 94% | 3053.24 | 812 / 861 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 93% | 21.21 | 27 / 29 |
tonsil | 0% | 0 | 0 / 0 | 91% | 26.95 | 41 / 45 |
eye | 0% | 0 | 0 / 0 | 85% | 21.52 | 68 / 80 |
peripheral blood | 43% | 1865.01 | 397 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0010256 | Biological process | endomembrane system organization |
GO_0035556 | Biological process | intracellular signal transduction |
GO_0032012 | Biological process | regulation of ARF protein signal transduction |
GO_0006887 | Biological process | exocytosis |
GO_0006893 | Biological process | Golgi to plasma membrane transport |
GO_0007032 | Biological process | endosome organization |
GO_0015031 | Biological process | protein transport |
GO_0032760 | Biological process | positive regulation of tumor necrosis factor production |
GO_0001881 | Biological process | receptor recycling |
GO_0098978 | Cellular component | glutamatergic synapse |
GO_0098793 | Cellular component | presynapse |
GO_0031410 | Cellular component | cytoplasmic vesicle |
GO_0043197 | Cellular component | dendritic spine |
GO_0048471 | Cellular component | perinuclear region of cytoplasm |
GO_0016020 | Cellular component | membrane |
GO_0055037 | Cellular component | recycling endosome |
GO_0005813 | Cellular component | centrosome |
GO_0005815 | Cellular component | microtubule organizing center |
GO_0005794 | Cellular component | Golgi apparatus |
GO_0005802 | Cellular component | trans-Golgi network |
GO_0005879 | Cellular component | axonemal microtubule |
GO_0098982 | Cellular component | GABA-ergic synapse |
GO_0000139 | Cellular component | Golgi membrane |
GO_0032279 | Cellular component | asymmetric synapse |
GO_0005829 | Cellular component | cytosol |
GO_0043231 | Cellular component | intracellular membrane-bounded organelle |
GO_0032280 | Cellular component | symmetric synapse |
GO_0005085 | Molecular function | guanyl-nucleotide exchange factor activity |
GO_0034237 | Molecular function | protein kinase A regulatory subunit binding |
GO_0050811 | Molecular function | GABA receptor binding |
GO_0017022 | Molecular function | myosin binding |
GO_0005515 | Molecular function | protein binding |
Gene name | ARFGEF2 |
Protein name | Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (Brefeldin A-inhibited GEP 2) (ADP-ribosylation factor guanine nucleotide-exchange factor 2) Alternative protein ARFGEF2 ARFGEF2 protein ADP ribosylation factor guanine nucleotide exchange factor 2 |
Synonyms | BIG2 ARFGEP2 |
Description | FUNCTION: Promotes guanine-nucleotide exchange on ARF1 and ARF3 and to a lower extent on ARF5 and ARF6. Promotes the activation of ARF1/ARF5/ARF6 through replacement of GDP with GTP. Involved in the regulation of Golgi vesicular transport. Required for the integrity of the endosomal compartment. Involved in trafficking from the trans-Golgi network (TGN) to endosomes and is required for membrane association of the AP-1 complex and GGA1. Seems to be involved in recycling of the transferrin receptor from recycling endosomes to the plasma membrane. Probably is involved in the exit of GABA(A) receptors from the endoplasmic reticulum. Involved in constitutive release of tumor necrosis factor receptor 1 via exosome-like vesicles; the function seems to involve PKA and specifically PRKAR2B. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways. . |
Accessions | A0A7P0TA34 ENST00000681885.1 A0A7P0TAV0 ENST00000681399.1 Q86TH5 A0A7P0T9L6 L8E9E5 A0A7P0T7Z2 A0A7P0Z446 ENST00000680871.1 ENST00000681021.1 ENST00000679436.1 ENST00000681656.1 Q9Y6D5 A0A7P0T9L9 ENST00000371917.5 |