ARFGEF2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0010256Biological processendomembrane system organization
GO_0035556Biological processintracellular signal transduction
GO_0032012Biological processregulation of ARF protein signal transduction
GO_0006887Biological processexocytosis
GO_0006893Biological processGolgi to plasma membrane transport
GO_0007032Biological processendosome organization
GO_0015031Biological processprotein transport
GO_0032760Biological processpositive regulation of tumor necrosis factor production
GO_0001881Biological processreceptor recycling
GO_0098978Cellular componentglutamatergic synapse
GO_0098793Cellular componentpresynapse
GO_0031410Cellular componentcytoplasmic vesicle
GO_0043197Cellular componentdendritic spine
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0016020Cellular componentmembrane
GO_0055037Cellular componentrecycling endosome
GO_0005813Cellular componentcentrosome
GO_0005815Cellular componentmicrotubule organizing center
GO_0005794Cellular componentGolgi apparatus
GO_0005802Cellular componenttrans-Golgi network
GO_0005879Cellular componentaxonemal microtubule
GO_0098982Cellular componentGABA-ergic synapse
GO_0000139Cellular componentGolgi membrane
GO_0032279Cellular componentasymmetric synapse
GO_0005829Cellular componentcytosol
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0032280Cellular componentsymmetric synapse
GO_0005085Molecular functionguanyl-nucleotide exchange factor activity
GO_0034237Molecular functionprotein kinase A regulatory subunit binding
GO_0050811Molecular functionGABA receptor binding
GO_0017022Molecular functionmyosin binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameARFGEF2
Protein nameBrefeldin A-inhibited guanine nucleotide-exchange protein 2 (Brefeldin A-inhibited GEP 2) (ADP-ribosylation factor guanine nucleotide-exchange factor 2)
Alternative protein ARFGEF2
ARFGEF2 protein
ADP ribosylation factor guanine nucleotide exchange factor 2
SynonymsBIG2
ARFGEP2
DescriptionFUNCTION: Promotes guanine-nucleotide exchange on ARF1 and ARF3 and to a lower extent on ARF5 and ARF6. Promotes the activation of ARF1/ARF5/ARF6 through replacement of GDP with GTP. Involved in the regulation of Golgi vesicular transport. Required for the integrity of the endosomal compartment. Involved in trafficking from the trans-Golgi network (TGN) to endosomes and is required for membrane association of the AP-1 complex and GGA1. Seems to be involved in recycling of the transferrin receptor from recycling endosomes to the plasma membrane. Probably is involved in the exit of GABA(A) receptors from the endoplasmic reticulum. Involved in constitutive release of tumor necrosis factor receptor 1 via exosome-like vesicles; the function seems to involve PKA and specifically PRKAR2B. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways. .

AccessionsA0A7P0TA34
ENST00000681885.1
A0A7P0TAV0
ENST00000681399.1
Q86TH5
A0A7P0T9L6
L8E9E5
A0A7P0T7Z2
A0A7P0Z446
ENST00000680871.1
ENST00000681021.1
ENST00000679436.1
ENST00000681656.1
Q9Y6D5
A0A7P0T9L9
ENST00000371917.5