NUCB2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	32 studies	29% ± 10%	Explore
fibroblast	32 studies	30% ± 16%	Explore
natural killer cell	31 studies	29% ± 13%	Explore
CD8-positive, alpha-beta T cell	28 studies	29% ± 13%	Explore
plasma cell	22 studies	50% ± 16%	Explore
plasmacytoid dendritic cell	21 studies	54% ± 13%	Explore
CD4-positive, alpha-beta T cell	20 studies	25% ± 10%	Explore
ciliated cell	19 studies	67% ± 18%	Explore
gamma-delta T cell	15 studies	29% ± 15%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	14 studies	29% ± 10%	Explore
CD16-negative, CD56-bright natural killer cell, human	14 studies	32% ± 9%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	13 studies	39% ± 16%	Explore
CD16-positive, CD56-dim natural killer cell, human	13 studies	26% ± 6%	Explore
T cell	12 studies	32% ± 12%	Explore
capillary endothelial cell	12 studies	22% ± 3%	Explore
vein endothelial cell	12 studies	25% ± 10%	Explore
plasmablast	11 studies	45% ± 21%	Explore
epithelial cell	11 studies	39% ± 15%	Explore
mature NK T cell	11 studies	22% ± 6%	Explore
connective tissue cell	11 studies	30% ± 6%	Explore
secretory cell	10 studies	35% ± 13%	Explore
endothelial cell of artery	10 studies	21% ± 5%	Explore
mucosal invariant T cell	10 studies	23% ± 4%	Explore
CD8-positive, alpha-beta memory T cell	9 studies	32% ± 13%	Explore
basal cell	9 studies	30% ± 17%	Explore
mesothelial cell	9 studies	28% ± 10%	Explore
endothelial cell of vascular tree	9 studies	24% ± 8%	Explore
club cell	8 studies	38% ± 12%	Explore
effector memory CD8-positive, alpha-beta T cell	8 studies	32% ± 18%	Explore
IgG plasma cell	8 studies	34% ± 6%	Explore
smooth muscle cell	8 studies	23% ± 6%	Explore
hematopoietic stem cell	8 studies	58% ± 19%	Explore
goblet cell	8 studies	31% ± 11%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	25% ± 6%	Explore
IgA plasma cell	7 studies	36% ± 10%	Explore
abnormal cell	7 studies	37% ± 13%	Explore
myofibroblast cell	7 studies	23% ± 5%	Explore
hematopoietic precursor cell	6 studies	64% ± 19%	Explore
CD4-positive, alpha-beta memory T cell	6 studies	23% ± 9%	Explore
respiratory goblet cell	6 studies	51% ± 18%	Explore
pericyte	6 studies	23% ± 5%	Explore
T follicular helper cell	6 studies	26% ± 6%	Explore
innate lymphoid cell	6 studies	23% ± 6%	Explore
conventional dendritic cell	5 studies	23% ± 3%	Explore
renal alpha-intercalated cell	5 studies	39% ± 8%	Explore
glutamatergic neuron	5 studies	44% ± 18%	Explore
erythroblast	5 studies	47% ± 16%	Explore
pro-B cell	5 studies	36% ± 14%	Explore
astrocyte	5 studies	31% ± 11%	Explore
mucus secreting cell	5 studies	36% ± 11%	Explore
double negative thymocyte	5 studies	65% ± 26%	Explore
B cell	5 studies	29% ± 16%	Explore
endothelial cell of lymphatic vessel	5 studies	24% ± 9%	Explore
GABAergic neuron	5 studies	38% ± 17%	Explore
mast cell	5 studies	21% ± 3%	Explore
interneuron	5 studies	37% ± 23%	Explore
central memory CD8-positive, alpha-beta T cell	4 studies	20% ± 5%	Explore
deuterosomal cell	4 studies	77% ± 5%	Explore
duct epithelial cell	4 studies	44% ± 13%	Explore
pancreatic A cell	4 studies	60% ± 14%	Explore
type B pancreatic cell	4 studies	65% ± 16%	Explore
leukocyte	4 studies	21% ± 7%	Explore
exhausted T cell	4 studies	34% ± 18%	Explore
glomerular endothelial cell	4 studies	43% ± 12%	Explore
precursor B cell	4 studies	36% ± 13%	Explore
retinal cone cell	4 studies	38% ± 12%	Explore
adventitial cell	4 studies	43% ± 8%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	42% ± 11%	Explore
neuron	4 studies	28% ± 7%	Explore
megakaryocyte-erythroid progenitor cell	4 studies	48% ± 30%	Explore
enteroendocrine cell	4 studies	26% ± 14%	Explore
regulatory T cell	4 studies	22% ± 10%	Explore
pancreatic D cell	3 studies	53% ± 15%	Explore
classical monocyte	3 studies	24% ± 8%	Explore
retinal bipolar neuron	3 studies	29% ± 9%	Explore
extravillous trophoblast	3 studies	73% ± 12%	Explore
placental villous trophoblast	3 studies	58% ± 24%	Explore
common myeloid progenitor	3 studies	65% ± 16%	Explore
type II pneumocyte	3 studies	31% ± 19%	Explore
progenitor cell	3 studies	61% ± 29%	Explore
retinal rod cell	3 studies	30% ± 8%	Explore
serous secreting cell	3 studies	60% ± 24%	Explore
Mueller cell	3 studies	30% ± 4%	Explore
rod bipolar cell	3 studies	26% ± 2%	Explore
effector CD4-positive, alpha-beta T cell	3 studies	22% ± 1%	Explore
macrophage	3 studies	22% ± 4%	Explore
dendritic cell	3 studies	26% ± 11%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	20% ± 5%	Explore
acinar cell	3 studies	53% ± 14%	Explore
granulocyte monocyte progenitor cell	3 studies	85% ± 10%	Explore
group 3 innate lymphoid cell	3 studies	25% ± 8%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	3 studies	23% ± 2%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	24% ± 8%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	14 studies	24% ± 11%	Explore
lung	13 studies	30% ± 13%	Explore
intestine	7 studies	22% ± 6%	Explore
eye	6 studies	25% ± 9%	Explore
bone marrow	6 studies	27% ± 8%	Explore
brain	6 studies	31% ± 13%	Explore
placenta	5 studies	37% ± 16%	Explore
liver	5 studies	25% ± 15%	Explore
lymph node	5 studies	24% ± 10%	Explore
pancreas	4 studies	54% ± 15%	Explore
uterus	4 studies	34% ± 5%	Explore
breast	4 studies	21% ± 1%	Explore
kidney	3 studies	20% ± 1%	Explore
thymus	3 studies	63% ± 33%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
breast	100%	2969.09	459 / 459	100%	68.89	1117 / 1118
adrenal gland	100%	2977.72	258 / 258	100%	52.47	229 / 230
thymus	100%	3454.87	653 / 653	100%	35.91	602 / 605
pancreas	100%	7875.60	328 / 328	99%	24.51	176 / 178
lung	100%	3403.93	576 / 578	99%	26.47	1144 / 1155
prostate	99%	2667.56	243 / 245	99%	56.11	499 / 502
brain	99%	1836.76	2621 / 2642	97%	14.79	682 / 705
esophagus	100%	3642.80	1443 / 1445	96%	17.44	175 / 183
uterus	100%	3166.63	170 / 170	95%	26.21	434 / 459
kidney	99%	1711.31	88 / 89	95%	23.66	860 / 901
stomach	100%	2502.13	359 / 359	91%	15.77	259 / 286
ovary	100%	2913.71	180 / 180	90%	15.97	389 / 430
intestine	99%	1905.36	957 / 966	87%	15.86	459 / 527
liver	92%	2930.44	209 / 226	93%	21.88	377 / 406
bladder	100%	2508.00	21 / 21	85%	15.04	430 / 504
skin	94%	2051.54	1696 / 1809	80%	19.78	379 / 472
spleen	100%	2185.11	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	19.51	45 / 45
blood vessel	100%	3262.32	1332 / 1335	0%	0	0 / 0
adipose	100%	2437.38	1200 / 1204	0%	0	0 / 0
heart	97%	3264.22	833 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	86%	11.01	25 / 29
muscle	81%	914.89	651 / 803	0%	0	0 / 0
peripheral blood	72%	1194.27	666 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	43%	5.01	34 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0051238	Biological process	sequestering of metal ion
GO_0007264	Biological process	small GTPase-mediated signal transduction
GO_0005615	Cellular component	extracellular space
GO_0070062	Cellular component	extracellular exosome
GO_0005783	Cellular component	endoplasmic reticulum
GO_0005829	Cellular component	cytosol
GO_0005794	Cellular component	Golgi apparatus
GO_0005886	Cellular component	plasma membrane
GO_0005635	Cellular component	nuclear envelope
GO_0005793	Cellular component	endoplasmic reticulum-Golgi intermediate compartment
GO_0003677	Molecular function	DNA binding
GO_0005085	Molecular function	guanyl-nucleotide exchange factor activity
GO_0001965	Molecular function	G-protein alpha-subunit binding
GO_0005509	Molecular function	calcium ion binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	NUCB2
Protein name	Nucleobindin 2 Nesfatin 1 Nucleobindin-2 (DNA-binding protein NEFA) (Epididymis secretory protein Li 109) (Gastric cancer antigen Zg4) (Prepronesfatin) [Cleaved into: Nesfatin-1]
Synonyms	NEFA
Description	FUNCTION: Calcium-binding protein which may have a role in calcium homeostasis (By similarity). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein (G-protein) alpha subunit GNAI3 (By similarity). .; FUNCTION: [Nesfatin-1]: Anorexigenic peptide, seems to play an important role in hypothalamic pathways regulating food intake and energy homeostasis, acting in a leptin-independent manner. May also exert hypertensive roles and modulate blood pressure through directly acting on peripheral arterial resistance. .
Accessions	ENST00000533926.5 A0A2R8Y6G7 E9PLR5 ENST00000526120.5 ENST00000530527.5 E9PKG6 ENST00000527735.1 ENST00000528644.5 A7LNF5 ENST00000527580.5 H0YEG8 A7LNF3 A0A097EV82 ENST00000531172.5 E9PRQ3 ENST00000529010.6 [P80303-1] E9PM22 A7LNF4 A0A1B0GXJ7 ENST00000533773.5 ENST00000530964.5 P80303 E9PJP3 ENST00000533738.6 H0YD18 E9PLR0 ENST00000529313.5 ENST00000323688.10 [P80303-2] ENST00000646648.1 E9PLE9

NUCB2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review