TRIO report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0048812Biological processneuron projection morphogenesis
GO_0051056Biological processregulation of small GTPase mediated signal transduction
GO_0099170Biological processpostsynaptic modulation of chemical synaptic transmission
GO_0045599Biological processnegative regulation of fat cell differentiation
GO_0007185Biological processcell surface receptor protein tyrosine phosphatase signaling pathway
GO_0007411Biological processaxon guidance
GO_0042995Cellular componentcell projection
GO_0098978Cellular componentglutamatergic synapse
GO_0048786Cellular componentpresynaptic active zone
GO_0005829Cellular componentcytosol
GO_0098794Cellular componentpostsynapse
GO_0019898Cellular componentextrinsic component of membrane
GO_0005737Cellular componentcytoplasm
GO_0005085Molecular functionguanyl-nucleotide exchange factor activity
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0106310Molecular functionprotein serine kinase activity
GO_0005515Molecular functionprotein binding
GO_0005524Molecular functionATP binding

IV. Literature review

[source]
Gene nameTRIO
Protein nameTrio Rho guanine nucleotide exchange factor
non-specific serine/threonine protein kinase (EC 2.7.11.1)
Triple functional domain protein (EC 2.7.11.1) (PTPRF-interacting protein)
Synonyms
DescriptionFUNCTION: Guanine nucleotide exchange factor (GEF) for RHOA and RAC1 GTPases . Involved in coordinating actin remodeling, which is necessary for cell migration and growth . Plays a key role in the regulation of neurite outgrowth and lamellipodia formation . In developing hippocampal neurons, limits dendrite formation, without affecting the establishment of axon polarity. Once dendrites are formed, involved in the control of synaptic function by regulating the endocytosis of AMPA-selective glutamate receptors (AMPARs) at CA1 excitatory synapses (By similarity). May act as a regulator of adipogenesis (By similarity). .

AccessionsENST00000698542.1
A0A8V8TLX5
E7EPJ7
F5H228
O75962
ENST00000509967.6
A0A1W2PRD7
ENST00000639876.2
ENST00000704488.1
A0A2X0SFJ0
E7EWP2
ENST00000512070.6
A0A994J7G8
ENST00000344204.9 [O75962-1]
ENST00000513206.5
ENST00000698541.1
A0A8V8TNC6