Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 29 studies | 53% ± 20% | |
astrocyte | 19 studies | 56% ± 18% | |
macrophage | 17 studies | 44% ± 23% | |
fibroblast | 17 studies | 41% ± 15% | |
microglial cell | 16 studies | 61% ± 19% | |
oligodendrocyte precursor cell | 15 studies | 72% ± 19% | |
smooth muscle cell | 12 studies | 48% ± 19% | |
glutamatergic neuron | 12 studies | 77% ± 18% | |
mast cell | 12 studies | 48% ± 17% | |
oligodendrocyte | 12 studies | 29% ± 13% | |
GABAergic neuron | 11 studies | 72% ± 20% | |
pericyte | 10 studies | 52% ± 15% | |
adipocyte | 10 studies | 67% ± 21% | |
epithelial cell | 9 studies | 38% ± 15% | |
myeloid cell | 9 studies | 37% ± 19% | |
endothelial cell of lymphatic vessel | 9 studies | 54% ± 24% | |
dendritic cell | 8 studies | 40% ± 15% | |
neuron | 7 studies | 55% ± 23% | |
B cell | 7 studies | 47% ± 13% | |
interneuron | 6 studies | 79% ± 16% | |
vein endothelial cell | 6 studies | 47% ± 26% | |
ciliated cell | 6 studies | 28% ± 14% | |
basal cell | 6 studies | 48% ± 24% | |
capillary endothelial cell | 5 studies | 35% ± 18% | |
cardiac muscle cell | 5 studies | 53% ± 15% | |
mesothelial cell | 5 studies | 47% ± 11% | |
monocyte | 5 studies | 46% ± 17% | |
club cell | 5 studies | 48% ± 19% | |
type I pneumocyte | 5 studies | 55% ± 11% | |
type II pneumocyte | 5 studies | 54% ± 9% | |
cholangiocyte | 4 studies | 58% ± 21% | |
hepatocyte | 4 studies | 60% ± 28% | |
connective tissue cell | 4 studies | 28% ± 13% | |
granule cell | 4 studies | 68% ± 14% | |
plasma cell | 4 studies | 43% ± 14% | |
endothelial cell of artery | 4 studies | 30% ± 13% | |
Mueller cell | 4 studies | 50% ± 20% | |
amacrine cell | 4 studies | 62% ± 25% | |
retina horizontal cell | 4 studies | 67% ± 20% | |
retinal cone cell | 4 studies | 38% ± 23% | |
retinal ganglion cell | 4 studies | 63% ± 25% | |
abnormal cell | 4 studies | 37% ± 19% | |
respiratory goblet cell | 4 studies | 51% ± 18% | |
alveolar macrophage | 4 studies | 58% ± 25% | |
endothelial cell of sinusoid | 3 studies | 26% ± 9% | |
hepatic stellate cell | 3 studies | 50% ± 22% | |
differentiation-committed oligodendrocyte precursor | 3 studies | 76% ± 14% | |
GABAergic interneuron | 3 studies | 77% ± 6% | |
progenitor cell | 3 studies | 58% ± 24% | |
GABAergic amacrine cell | 3 studies | 69% ± 18% | |
ON-bipolar cell | 3 studies | 46% ± 23% | |
glycinergic amacrine cell | 3 studies | 55% ± 15% | |
endothelial cell of vascular tree | 3 studies | 56% ± 20% | |
ependymal cell | 3 studies | 65% ± 15% | |
myofibroblast cell | 3 studies | 52% ± 23% | |
muscle cell | 3 studies | 45% ± 36% | |
goblet cell | 3 studies | 51% ± 31% | |
transit amplifying cell | 3 studies | 41% ± 31% | |
mucus secreting cell | 3 studies | 38% ± 3% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
intestine | 100% | 9015.44 | 966 / 966 | 100% | 18.68 | 525 / 527 |
esophagus | 99% | 7499.84 | 1437 / 1445 | 100% | 29.07 | 183 / 183 |
lung | 100% | 7458.89 | 577 / 578 | 99% | 27.08 | 1140 / 1155 |
breast | 100% | 8823.69 | 459 / 459 | 98% | 25.64 | 1101 / 1118 |
stomach | 98% | 5180.07 | 353 / 359 | 99% | 19.69 | 283 / 286 |
ovary | 100% | 12211.97 | 180 / 180 | 97% | 15.35 | 417 / 430 |
brain | 97% | 6791.15 | 2559 / 2642 | 100% | 37.36 | 703 / 705 |
bladder | 100% | 7661.38 | 21 / 21 | 95% | 17.32 | 481 / 504 |
skin | 100% | 9983.71 | 1807 / 1809 | 95% | 16.58 | 450 / 472 |
uterus | 100% | 9816.31 | 170 / 170 | 94% | 17.30 | 433 / 459 |
prostate | 100% | 7375.80 | 244 / 245 | 94% | 14.17 | 474 / 502 |
kidney | 100% | 4341.79 | 89 / 89 | 94% | 14.47 | 846 / 901 |
adrenal gland | 100% | 5140.58 | 258 / 258 | 91% | 15.27 | 209 / 230 |
pancreas | 92% | 2924.24 | 303 / 328 | 98% | 18.96 | 175 / 178 |
thymus | 100% | 5119.37 | 651 / 653 | 83% | 7.56 | 502 / 605 |
liver | 93% | 2718.15 | 211 / 226 | 64% | 5.98 | 259 / 406 |
adipose | 100% | 8702.21 | 1204 / 1204 | 0% | 0 | 0 / 0 |
spleen | 100% | 8726.07 | 241 / 241 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 7.47 | 1 / 1 |
blood vessel | 100% | 8455.67 | 1334 / 1335 | 0% | 0 | 0 / 0 |
muscle | 99% | 3611.24 | 792 / 803 | 0% | 0 | 0 / 0 |
heart | 98% | 4378.59 | 843 / 861 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 93% | 13.16 | 42 / 45 |
eye | 0% | 0 | 0 / 0 | 89% | 9.87 | 71 / 80 |
lymph node | 0% | 0 | 0 / 0 | 66% | 8.08 | 19 / 29 |
peripheral blood | 25% | 2687.09 | 232 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0048812 | Biological process | neuron projection morphogenesis |
GO_0051056 | Biological process | regulation of small GTPase mediated signal transduction |
GO_0099170 | Biological process | postsynaptic modulation of chemical synaptic transmission |
GO_0045599 | Biological process | negative regulation of fat cell differentiation |
GO_0007185 | Biological process | cell surface receptor protein tyrosine phosphatase signaling pathway |
GO_0007411 | Biological process | axon guidance |
GO_0042995 | Cellular component | cell projection |
GO_0098978 | Cellular component | glutamatergic synapse |
GO_0048786 | Cellular component | presynaptic active zone |
GO_0005829 | Cellular component | cytosol |
GO_0098794 | Cellular component | postsynapse |
GO_0019898 | Cellular component | extrinsic component of membrane |
GO_0005737 | Cellular component | cytoplasm |
GO_0005085 | Molecular function | guanyl-nucleotide exchange factor activity |
GO_0004674 | Molecular function | protein serine/threonine kinase activity |
GO_0106310 | Molecular function | protein serine kinase activity |
GO_0005515 | Molecular function | protein binding |
GO_0005524 | Molecular function | ATP binding |
Gene name | TRIO |
Protein name | Trio Rho guanine nucleotide exchange factor non-specific serine/threonine protein kinase (EC 2.7.11.1) Triple functional domain protein (EC 2.7.11.1) (PTPRF-interacting protein) |
Synonyms | |
Description | FUNCTION: Guanine nucleotide exchange factor (GEF) for RHOA and RAC1 GTPases . Involved in coordinating actin remodeling, which is necessary for cell migration and growth . Plays a key role in the regulation of neurite outgrowth and lamellipodia formation . In developing hippocampal neurons, limits dendrite formation, without affecting the establishment of axon polarity. Once dendrites are formed, involved in the control of synaptic function by regulating the endocytosis of AMPA-selective glutamate receptors (AMPARs) at CA1 excitatory synapses (By similarity). May act as a regulator of adipogenesis (By similarity). . |
Accessions | ENST00000698542.1 A0A8V8TLX5 E7EPJ7 F5H228 O75962 ENST00000509967.6 A0A1W2PRD7 ENST00000639876.2 ENST00000704488.1 A0A2X0SFJ0 E7EWP2 ENST00000512070.6 A0A994J7G8 ENST00000344204.9 [O75962-1] ENST00000513206.5 ENST00000698541.1 A0A8V8TNC6 |