EIF2B2 | OmnibusX

Name	Number of supported studies	Average coverage
epithelial cell	4 studies	25% ± 6%	Explore
dendritic cell	3 studies	21% ± 2%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of EIF2B2 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	1486.06	1445 / 1445	100%	12.45	183 / 183
intestine	100%	1456.67	966 / 966	100%	15.14	527 / 527
kidney	100%	1652.39	89 / 89	100%	15.30	901 / 901
ovary	100%	1196.02	180 / 180	100%	15.04	430 / 430
stomach	100%	1094.98	359 / 359	100%	14.02	286 / 286
thymus	100%	2822.84	653 / 653	100%	27.54	605 / 605
uterus	100%	1384.74	170 / 170	100%	15.80	459 / 459
lung	100%	1363.17	577 / 578	100%	14.21	1155 / 1155
brain	100%	1212.41	2637 / 2642	100%	18.67	705 / 705
prostate	100%	1469.22	245 / 245	100%	12.71	501 / 502
skin	100%	1558.36	1809 / 1809	100%	20.18	471 / 472
pancreas	100%	797.52	327 / 328	100%	14.36	178 / 178
breast	100%	1445.69	459 / 459	100%	13.75	1114 / 1118
bladder	100%	1493.00	21 / 21	99%	14.46	500 / 504
liver	100%	736.63	225 / 226	100%	9.16	404 / 406
adrenal gland	100%	2277.48	258 / 258	98%	14.51	226 / 230
adipose	100%	1412.03	1204 / 1204	0%	0	0 / 0
blood vessel	100%	1819.54	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	18.77	29 / 29
muscle	100%	2045.16	803 / 803	0%	0	0 / 0
spleen	100%	1267.90	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	13.77	45 / 45
ureter	0%	0	0 / 0	100%	11.19	1 / 1
eye	0%	0	0 / 0	99%	13.36	79 / 80
heart	98%	984.88	848 / 861	0%	0	0 / 0
peripheral blood	95%	880.00	879 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0014003	Biological process	oligodendrocyte development
GO_0002183	Biological process	cytoplasmic translational initiation
GO_0009408	Biological process	response to heat
GO_0043434	Biological process	response to peptide hormone
GO_0009749	Biological process	response to glucose
GO_0042552	Biological process	myelination
GO_0001541	Biological process	ovarian follicle development
GO_0006413	Biological process	translational initiation
GO_0050852	Biological process	T cell receptor signaling pathway
GO_0006446	Biological process	regulation of translational initiation
GO_0007417	Biological process	central nervous system development
GO_0005851	Cellular component	eukaryotic translation initiation factor 2B complex
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0005085	Molecular function	guanyl-nucleotide exchange factor activity
GO_0003743	Molecular function	translation initiation factor activity
GO_0005525	Molecular function	GTP binding
GO_0005524	Molecular function	ATP binding
GO_0005515	Molecular function	protein binding

Gene name	EIF2B2
Protein name	Translation initiation factor eIF2B subunit beta (eIF2B GDP-GTP exchange factor subunit beta) Translation initiation factor eIF2B subunit beta (S20I15) (S20III15) (eIF2B GDP-GTP exchange factor subunit beta)
Synonyms	hCG_22350 EIF2BB
Description	FUNCTION: Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on eukaryotic initiation factor 2 (eIF2) gamma subunit . Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed . .
Accessions	ENST00000266126.10 ENST00000553401.5 ENST00000556028.5 H0YK01 G3V5E5 Q53XC2 H0YJJ8 P49770 Q9BPX4 ENST00000554748.2

EIF2B2 report