I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| glutamatergic neuron | 5 studies | 25% ± 6% | |
| smooth muscle cell | 3 studies | 21% ± 2% | |
| pericyte | 3 studies | 17% ± 1% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| glutamatergic neuron | 5 studies | 25% ± 6% | |
| smooth muscle cell | 3 studies | 21% ± 2% | |
| pericyte | 3 studies | 17% ± 1% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 3 studies | 22% ± 4% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| prostate | 100% | 5071.40 | 244 / 245 | 94% | 4.69 | 474 / 502 |
| ovary | 100% | 4272.37 | 180 / 180 | 93% | 4.73 | 402 / 430 |
| brain | 89% | 4202.90 | 2362 / 2642 | 100% | 14.35 | 702 / 705 |
| breast | 93% | 2263.43 | 429 / 459 | 90% | 2.88 | 1010 / 1118 |
| bladder | 100% | 6431.05 | 21 / 21 | 65% | 2.03 | 329 / 504 |
| lung | 85% | 1510.05 | 492 / 578 | 80% | 2.62 | 924 / 1155 |
| uterus | 99% | 7672.93 | 168 / 170 | 58% | 3.14 | 268 / 459 |
| esophagus | 84% | 5642.67 | 1212 / 1445 | 58% | 1.95 | 107 / 183 |
| intestine | 88% | 6926.57 | 849 / 966 | 50% | 1.33 | 265 / 527 |
| skin | 36% | 463.25 | 643 / 1809 | 91% | 3.81 | 431 / 472 |
| kidney | 46% | 737.70 | 41 / 89 | 71% | 2.04 | 642 / 901 |
| stomach | 61% | 2832.77 | 220 / 359 | 56% | 1.94 | 160 / 286 |
| adrenal gland | 32% | 412.18 | 82 / 258 | 76% | 4.19 | 175 / 230 |
| thymus | 66% | 939.74 | 428 / 653 | 40% | 0.72 | 242 / 605 |
| blood vessel | 100% | 7207.98 | 1334 / 1335 | 0% | 0 | 0 / 0 |
| pancreas | 4% | 38.56 | 12 / 328 | 93% | 3.86 | 165 / 178 |
| adipose | 92% | 2359.42 | 1106 / 1204 | 0% | 0 | 0 / 0 |
| spleen | 84% | 1474.20 | 203 / 241 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 84% | 2.08 | 67 / 80 |
| heart | 66% | 927.02 | 566 / 861 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 38% | 0.68 | 17 / 45 |
| lymph node | 0% | 0 | 0 / 0 | 28% | 0.34 | 8 / 29 |
| liver | 2% | 19.38 | 4 / 226 | 20% | 0.50 | 80 / 406 |
| muscle | 4% | 50.98 | 33 / 803 | 0% | 0 | 0 / 0 |
| peripheral blood | 1% | 11.36 | 10 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0051056 | Biological process | regulation of small GTPase mediated signal transduction |
| GO_0007411 | Biological process | axon guidance |
| GO_0030016 | Cellular component | myofibril |
| GO_0030017 | Cellular component | sarcomere |
| GO_0005829 | Cellular component | cytosol |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0019898 | Cellular component | extrinsic component of membrane |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0005085 | Molecular function | guanyl-nucleotide exchange factor activity |
| Gene name | ARHGEF25 |
| Protein name | ARHGEF25 Rho guanine nucleotide exchange factor 25 (Guanine nucleotide exchange factor GEFT) (Rac/Cdc42/Rho exchange factor GEFT) (RhoA/Rac/Cdc42 guanine nucleotide exchange factor GEFT) (p63RhoGEF) |
| Synonyms | GEFT |
| Description | FUNCTION: May play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. It works as a guanine nucleotide exchange factor for Rho family of small GTPases. Links specifically G alpha q/11-coupled receptors to RHOA activation. May be an important regulator of processes involved in axon and dendrite formation. In neurons seems to be an exchange factor primarily for RAC1. Involved in skeletal myogenesis (By similarity). . |
| Accessions | ENST00000616622.1 [Q86VW2-2] ENST00000333972.11 [Q86VW2-3] Q86VW2 A0A2X0SYW9 ENST00000286494.9 [Q86VW2-1] |
