IQSEC1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030036Biological processactin cytoskeleton organization
GO_0032012Biological processregulation of ARF protein signal transduction
GO_0060996Biological processdendritic spine development
GO_0051549Biological processpositive regulation of keratinocyte migration
GO_0120183Biological processpositive regulation of focal adhesion disassembly
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0014069Cellular componentpostsynaptic density
GO_0005730Cellular componentnucleolus
GO_0008021Cellular componentsynaptic vesicle
GO_0016020Cellular componentmembrane
GO_0005085Molecular functionguanyl-nucleotide exchange factor activity
GO_0005515Molecular functionprotein binding
GO_0008289Molecular functionlipid binding

IV. Literature review

[source]
Gene nameIQSEC1
Protein nameAlternative protein IQSEC1
IQ motif and SEC7 domain-containing protein 1 (ADP-ribosylation factors guanine nucleotide-exchange protein 100) (ADP-ribosylation factors guanine nucleotide-exchange protein 2) (Brefeldin-resistant Arf-GEF 2 protein) (BRAG2)
IQ motif and Sec7 domain ArfGEF 1
Epididymis secretory sperm binding protein (IQ motif and Sec7 domain ArfGEF 1)
SynonymsARFGEP100
KIAA0763
BRAG2
DescriptionFUNCTION: Guanine nucleotide exchange factor for ARF1 and ARF6 . Guanine nucleotide exchange factor activity is enhanced by lipid binding . Accelerates GTP binding by ARFs of all three classes. Guanine nucleotide exchange protein for ARF6, mediating internalization of beta-1 integrin . Involved in neuronal development (Probable). In neurons, plays a role in the control of vesicle formation by endocytoc cargo. Upon long term depression, interacts with GRIA2 and mediates the activation of ARF6 to internalize synaptic AMPAR receptors (By similarity). .

AccessionsENST00000618604.4
ENST00000707112.1
ENST00000648114.1
A0A3B3IRZ4
A0A0C4DGT3
A0A2R8Y695
ENST00000613206.2 [Q6DN90-3]
ENST00000646269.1
A0A2R8Y7T6
L0R4Y9
Q6DN90
ENST00000273221.8 [Q6DN90-1]
A0A3B3IU98
ENST00000648386.1
A0A9L9PXV7
ENST00000647458.1