Name | Number of supported studies | Average coverage | |
---|---|---|---|
B cell | 19 studies | 26% ± 10% | |
endothelial cell | 14 studies | 37% ± 15% | |
classical monocyte | 11 studies | 21% ± 9% | |
glutamatergic neuron | 11 studies | 52% ± 25% | |
astrocyte | 11 studies | 28% ± 13% | |
non-classical monocyte | 10 studies | 23% ± 12% | |
GABAergic neuron | 10 studies | 43% ± 24% | |
oligodendrocyte precursor cell | 10 studies | 32% ± 13% | |
oligodendrocyte | 9 studies | 28% ± 10% | |
macrophage | 8 studies | 28% ± 10% | |
retinal cone cell | 7 studies | 46% ± 17% | |
monocyte | 7 studies | 26% ± 8% | |
interneuron | 6 studies | 49% ± 21% | |
retinal ganglion cell | 6 studies | 57% ± 16% | |
memory B cell | 6 studies | 19% ± 4% | |
naive B cell | 6 studies | 22% ± 4% | |
retinal rod cell | 6 studies | 43% ± 19% | |
endothelial cell of lymphatic vessel | 6 studies | 27% ± 13% | |
plasmacytoid dendritic cell | 6 studies | 22% ± 6% | |
natural killer cell | 5 studies | 21% ± 4% | |
ciliated cell | 5 studies | 22% ± 3% | |
CD16-positive, CD56-dim natural killer cell, human | 5 studies | 18% ± 3% | |
neuron | 5 studies | 32% ± 10% | |
pericyte | 5 studies | 29% ± 16% | |
myeloid cell | 5 studies | 23% ± 4% | |
retina horizontal cell | 5 studies | 53% ± 19% | |
fibroblast | 5 studies | 23% ± 6% | |
adipocyte | 5 studies | 32% ± 12% | |
dendritic cell | 5 studies | 26% ± 16% | |
retinal bipolar neuron | 4 studies | 24% ± 1% | |
granule cell | 4 studies | 29% ± 2% | |
amacrine cell | 4 studies | 25% ± 9% | |
neutrophil | 3 studies | 18% ± 1% | |
glomerular endothelial cell | 3 studies | 18% ± 1% | |
GABAergic interneuron | 3 studies | 40% ± 4% | |
microglial cell | 3 studies | 45% ± 9% | |
plasma cell | 3 studies | 35% ± 3% | |
epithelial cell | 3 studies | 23% ± 9% | |
immature B cell | 3 studies | 24% ± 5% | |
effector memory CD8-positive, alpha-beta T cell | 3 studies | 18% ± 2% | |
OFF-bipolar cell | 3 studies | 40% ± 13% | |
ON-bipolar cell | 3 studies | 45% ± 20% | |
rod bipolar cell | 3 studies | 43% ± 8% | |
alveolar macrophage | 3 studies | 35% ± 13% | |
lymphocyte | 3 studies | 31% ± 9% | |
hepatocyte | 3 studies | 43% ± 16% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
prostate | 100% | 6215.71 | 245 / 245 | 100% | 38.77 | 502 / 502 |
brain | 100% | 12584.07 | 2639 / 2642 | 100% | 38.25 | 704 / 705 |
thymus | 100% | 4469.02 | 652 / 653 | 100% | 24.92 | 604 / 605 |
breast | 100% | 5284.11 | 459 / 459 | 99% | 31.31 | 1109 / 1118 |
liver | 99% | 4165.49 | 224 / 226 | 100% | 30.59 | 405 / 406 |
kidney | 100% | 3843.91 | 89 / 89 | 99% | 22.99 | 890 / 901 |
stomach | 100% | 3594.69 | 358 / 359 | 99% | 23.39 | 283 / 286 |
intestine | 100% | 4783.04 | 965 / 966 | 99% | 18.40 | 520 / 527 |
lung | 100% | 7322.51 | 578 / 578 | 98% | 20.41 | 1135 / 1155 |
adrenal gland | 100% | 9372.15 | 258 / 258 | 98% | 30.17 | 225 / 230 |
bladder | 100% | 4981.19 | 21 / 21 | 97% | 17.77 | 491 / 504 |
skin | 98% | 2893.98 | 1778 / 1809 | 99% | 25.09 | 467 / 472 |
pancreas | 98% | 2665.91 | 321 / 328 | 99% | 26.97 | 176 / 178 |
uterus | 100% | 5477.95 | 170 / 170 | 95% | 16.39 | 438 / 459 |
ovary | 100% | 5135.73 | 180 / 180 | 95% | 16.89 | 407 / 430 |
esophagus | 94% | 4432.77 | 1363 / 1445 | 99% | 22.77 | 182 / 183 |
adipose | 100% | 6421.27 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 9146.27 | 1335 / 1335 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 100% | 18.80 | 80 / 80 |
lymph node | 0% | 0 | 0 / 0 | 100% | 47.25 | 29 / 29 |
spleen | 100% | 12115.26 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 19.09 | 45 / 45 |
peripheral blood | 100% | 12341.84 | 925 / 929 | 0% | 0 | 0 / 0 |
heart | 99% | 5169.48 | 854 / 861 | 0% | 0 | 0 / 0 |
muscle | 98% | 3331.56 | 787 / 803 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0030036 | Biological process | actin cytoskeleton organization |
GO_0032012 | Biological process | regulation of ARF protein signal transduction |
GO_0060996 | Biological process | dendritic spine development |
GO_0051549 | Biological process | positive regulation of keratinocyte migration |
GO_0120183 | Biological process | positive regulation of focal adhesion disassembly |
GO_0043231 | Cellular component | intracellular membrane-bounded organelle |
GO_0014069 | Cellular component | postsynaptic density |
GO_0005730 | Cellular component | nucleolus |
GO_0008021 | Cellular component | synaptic vesicle |
GO_0016020 | Cellular component | membrane |
GO_0005085 | Molecular function | guanyl-nucleotide exchange factor activity |
GO_0005515 | Molecular function | protein binding |
GO_0008289 | Molecular function | lipid binding |
Gene name | IQSEC1 |
Protein name | Alternative protein IQSEC1 IQ motif and SEC7 domain-containing protein 1 (ADP-ribosylation factors guanine nucleotide-exchange protein 100) (ADP-ribosylation factors guanine nucleotide-exchange protein 2) (Brefeldin-resistant Arf-GEF 2 protein) (BRAG2) IQ motif and Sec7 domain ArfGEF 1 Epididymis secretory sperm binding protein (IQ motif and Sec7 domain ArfGEF 1) |
Synonyms | ARFGEP100 KIAA0763 BRAG2 |
Description | FUNCTION: Guanine nucleotide exchange factor for ARF1 and ARF6 . Guanine nucleotide exchange factor activity is enhanced by lipid binding . Accelerates GTP binding by ARFs of all three classes. Guanine nucleotide exchange protein for ARF6, mediating internalization of beta-1 integrin . Involved in neuronal development (Probable). In neurons, plays a role in the control of vesicle formation by endocytoc cargo. Upon long term depression, interacts with GRIA2 and mediates the activation of ARF6 to internalize synaptic AMPAR receptors (By similarity). . |
Accessions | ENST00000618604.4 ENST00000707112.1 ENST00000648114.1 A0A3B3IRZ4 A0A0C4DGT3 A0A2R8Y695 ENST00000613206.2 [Q6DN90-3] ENST00000646269.1 A0A2R8Y7T6 L0R4Y9 Q6DN90 ENST00000273221.8 [Q6DN90-1] A0A3B3IU98 ENST00000648386.1 A0A9L9PXV7 ENST00000647458.1 |