RAP1GDS1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1904464Biological processregulation of matrix metallopeptidase secretion
GO_0086098Biological processangiotensin-activated signaling pathway involved in heart process
GO_0070376Biological processregulation of ERK5 cascade
GO_0031034Biological processmyosin filament assembly
GO_0003300Biological processcardiac muscle hypertrophy
GO_0010821Biological processregulation of mitochondrion organization
GO_0014829Biological processvascular associated smooth muscle contraction
GO_0034504Biological processprotein localization to nucleus
GO_0080120Biological processCAAX-box protein maturation
GO_0032471Biological processnegative regulation of endoplasmic reticulum calcium ion concentration
GO_0051561Biological processpositive regulation of mitochondrial calcium ion concentration
GO_0070062Cellular componentextracellular exosome
GO_0005783Cellular componentendoplasmic reticulum
GO_0005829Cellular componentcytosol
GO_0005739Cellular componentmitochondrion
GO_0005634Cellular componentnucleus
GO_0005085Molecular functionguanyl-nucleotide exchange factor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameRAP1GDS1
Protein nameRap1 GTPase-GDP dissociation stimulator 1
Rap1 GTPase-GDP dissociation stimulator 1 (Exchange factor smgGDS) (SMG GDS protein) (SMG P21 stimulatory GDP/GTP exchange protein)
SynonymsSMGGDS
DescriptionFUNCTION: Acts as a GEF (guanine nucleotide exchange factor) for the Rho family of small GTP-binding proteins (G proteins) that stimulates the dissociation of GDP to enable subsequent binding of GTP . Additionally, appears to chaperone the processing and/or trafficking of small GTPases containing a C-terminal polybasic region independently of GEF activity . Targets include RAP1A/RAP1B, RHOA, RHOB, RHOC, RAC1 and KRAS . Regulates mitochondrial dynamics by controlling RHOT function to promote mitochondrial fission during high calcium conditions . Able to promote the Ca(2+) release from the endoplasmic reticulum via both inositol trisphosphate (Ins3P) and ryanodine sensitive receptors leading to a enhanced mitochondrial Ca(2+) uptake . .; FUNCTION: [Isoform 1]: Acts as a GEF (guanine nucleotide exchange factor) for unprenylated RHOA . Chaperones the entry and passage of small GTPases through the prenylation pathway . Recognizes the last amino acid in the GTPase C-terminal CAAX motif with a preference for 'Leu' over 'Met', indicating involvement in the geranylgeranylation pathway . .; FUNCTION: [Isoform 2]: Acts as a GEF (guanine nucleotide exchange factor) for prenylated RHOA . Acts as a GEF for RHOC . Chaperones the downstream trafficking and/or processing of small newly prenylated GTPases . Escorts RAC1 to the nucleus . .

AccessionsENST00000509011.5
D6RC12
D6RHH8
D6RHZ7
ENST00000511212.5
ENST00000510870.5
ENST00000339360.9 [P52306-5]
ENST00000380158.8 [P52306-3]
H0Y8M2
P52306
D6RB97
ENST00000503667.5
D6RBC6
ENST00000264572.11 [P52306-6]
ENST00000408900.7 [P52306-2]
ENST00000509501.5
ENST00000408927.8 [P52306-1]
D6RC85
U3KQJ4
ENST00000514139.2
ENST00000514122.5
ENST00000508213.5
D6REZ0
ENST00000453712.6 [P52306-4]
ENST00000508490.5