Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 19 studies | 29% ± 10% | |
oligodendrocyte | 15 studies | 48% ± 14% | |
natural killer cell | 14 studies | 21% ± 7% | |
astrocyte | 13 studies | 35% ± 15% | |
glutamatergic neuron | 12 studies | 48% ± 23% | |
microglial cell | 12 studies | 32% ± 10% | |
regulatory T cell | 12 studies | 22% ± 7% | |
GABAergic neuron | 11 studies | 43% ± 24% | |
CD16-negative, CD56-bright natural killer cell, human | 11 studies | 24% ± 11% | |
oligodendrocyte precursor cell | 11 studies | 31% ± 12% | |
macrophage | 11 studies | 30% ± 11% | |
plasmacytoid dendritic cell | 11 studies | 27% ± 9% | |
B cell | 10 studies | 23% ± 8% | |
dendritic cell | 9 studies | 31% ± 12% | |
adipocyte | 8 studies | 25% ± 8% | |
CD4-positive, alpha-beta T cell | 7 studies | 24% ± 11% | |
neuron | 7 studies | 40% ± 17% | |
retinal ganglion cell | 7 studies | 50% ± 25% | |
retinal cone cell | 7 studies | 48% ± 19% | |
T cell | 7 studies | 25% ± 7% | |
CD16-positive, CD56-dim natural killer cell, human | 6 studies | 20% ± 8% | |
myeloid cell | 6 studies | 25% ± 10% | |
epithelial cell | 6 studies | 25% ± 12% | |
retinal rod cell | 6 studies | 43% ± 18% | |
CD8-positive, alpha-beta T cell | 6 studies | 23% ± 8% | |
endothelial cell of lymphatic vessel | 6 studies | 37% ± 11% | |
fibroblast | 6 studies | 20% ± 3% | |
pericyte | 6 studies | 25% ± 5% | |
cardiac muscle cell | 5 studies | 20% ± 3% | |
type I pneumocyte | 5 studies | 27% ± 8% | |
interneuron | 5 studies | 48% ± 21% | |
granule cell | 4 studies | 33% ± 9% | |
amacrine cell | 4 studies | 35% ± 20% | |
retina horizontal cell | 4 studies | 24% ± 13% | |
retinal bipolar neuron | 4 studies | 31% ± 9% | |
effector memory CD8-positive, alpha-beta T cell | 4 studies | 29% ± 12% | |
mast cell | 4 studies | 21% ± 7% | |
lymphocyte | 4 studies | 41% ± 19% | |
OFF-bipolar cell | 4 studies | 35% ± 13% | |
ON-bipolar cell | 4 studies | 46% ± 14% | |
club cell | 4 studies | 20% ± 7% | |
monocyte | 4 studies | 29% ± 7% | |
smooth muscle cell | 4 studies | 21% ± 2% | |
type II pneumocyte | 4 studies | 20% ± 5% | |
basal cell | 4 studies | 29% ± 16% | |
conventional dendritic cell | 3 studies | 28% ± 8% | |
GABAergic interneuron | 3 studies | 35% ± 3% | |
glial cell | 3 studies | 21% ± 3% | |
precursor B cell | 3 studies | 19% ± 1% | |
mononuclear phagocyte | 3 studies | 24% ± 3% | |
non-classical monocyte | 3 studies | 18% ± 3% | |
GABAergic amacrine cell | 3 studies | 34% ± 15% | |
glycinergic amacrine cell | 3 studies | 25% ± 1% | |
rod bipolar cell | 3 studies | 35% ± 13% | |
endothelial cell of vascular tree | 3 studies | 25% ± 12% | |
hepatocyte | 3 studies | 27% ± 9% | |
mature NK T cell | 3 studies | 25% ± 8% | |
alveolar macrophage | 3 studies | 36% ± 8% | |
gamma-delta T cell | 3 studies | 21% ± 7% | |
leukocyte | 3 studies | 48% ± 13% | |
transit amplifying cell | 3 studies | 34% ± 23% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
breast | 100% | 1975.00 | 459 / 459 | 100% | 43.64 | 1118 / 1118 |
uterus | 100% | 1709.95 | 170 / 170 | 100% | 25.31 | 459 / 459 |
brain | 100% | 5263.54 | 2640 / 2642 | 100% | 42.51 | 705 / 705 |
intestine | 100% | 2112.49 | 966 / 966 | 100% | 25.03 | 526 / 527 |
bladder | 100% | 1961.19 | 21 / 21 | 99% | 24.30 | 501 / 504 |
esophagus | 100% | 2069.34 | 1444 / 1445 | 99% | 20.59 | 182 / 183 |
thymus | 100% | 1530.59 | 651 / 653 | 100% | 24.53 | 602 / 605 |
ovary | 100% | 1371.99 | 180 / 180 | 99% | 13.71 | 426 / 430 |
prostate | 100% | 1480.21 | 244 / 245 | 99% | 18.49 | 499 / 502 |
lung | 99% | 1912.98 | 573 / 578 | 100% | 22.06 | 1151 / 1155 |
kidney | 100% | 1530.27 | 89 / 89 | 99% | 19.26 | 889 / 901 |
stomach | 100% | 1344.89 | 358 / 359 | 99% | 21.18 | 282 / 286 |
pancreas | 98% | 1536.52 | 321 / 328 | 100% | 22.28 | 178 / 178 |
skin | 100% | 2727.26 | 1808 / 1809 | 97% | 31.76 | 459 / 472 |
adrenal gland | 98% | 1343.22 | 254 / 258 | 97% | 27.27 | 223 / 230 |
liver | 95% | 1145.60 | 215 / 226 | 94% | 12.97 | 383 / 406 |
adipose | 100% | 1974.01 | 1204 / 1204 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 30.94 | 29 / 29 |
spleen | 100% | 2510.11 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 24.88 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 11.22 | 1 / 1 |
blood vessel | 100% | 2180.23 | 1331 / 1335 | 0% | 0 | 0 / 0 |
peripheral blood | 86% | 1294.94 | 796 / 929 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 84% | 12.09 | 67 / 80 |
heart | 79% | 690.95 | 679 / 861 | 0% | 0 | 0 / 0 |
muscle | 37% | 263.98 | 298 / 803 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_1904464 | Biological process | regulation of matrix metallopeptidase secretion |
GO_0086098 | Biological process | angiotensin-activated signaling pathway involved in heart process |
GO_0070376 | Biological process | regulation of ERK5 cascade |
GO_0031034 | Biological process | myosin filament assembly |
GO_0003300 | Biological process | cardiac muscle hypertrophy |
GO_0010821 | Biological process | regulation of mitochondrion organization |
GO_0014829 | Biological process | vascular associated smooth muscle contraction |
GO_0034504 | Biological process | protein localization to nucleus |
GO_0080120 | Biological process | CAAX-box protein maturation |
GO_0032471 | Biological process | negative regulation of endoplasmic reticulum calcium ion concentration |
GO_0051561 | Biological process | positive regulation of mitochondrial calcium ion concentration |
GO_0070062 | Cellular component | extracellular exosome |
GO_0005783 | Cellular component | endoplasmic reticulum |
GO_0005829 | Cellular component | cytosol |
GO_0005739 | Cellular component | mitochondrion |
GO_0005634 | Cellular component | nucleus |
GO_0005085 | Molecular function | guanyl-nucleotide exchange factor activity |
GO_0005515 | Molecular function | protein binding |
Gene name | RAP1GDS1 |
Protein name | Rap1 GTPase-GDP dissociation stimulator 1 Rap1 GTPase-GDP dissociation stimulator 1 (Exchange factor smgGDS) (SMG GDS protein) (SMG P21 stimulatory GDP/GTP exchange protein) |
Synonyms | SMGGDS |
Description | FUNCTION: Acts as a GEF (guanine nucleotide exchange factor) for the Rho family of small GTP-binding proteins (G proteins) that stimulates the dissociation of GDP to enable subsequent binding of GTP . Additionally, appears to chaperone the processing and/or trafficking of small GTPases containing a C-terminal polybasic region independently of GEF activity . Targets include RAP1A/RAP1B, RHOA, RHOB, RHOC, RAC1 and KRAS . Regulates mitochondrial dynamics by controlling RHOT function to promote mitochondrial fission during high calcium conditions . Able to promote the Ca(2+) release from the endoplasmic reticulum via both inositol trisphosphate (Ins3P) and ryanodine sensitive receptors leading to a enhanced mitochondrial Ca(2+) uptake . .; FUNCTION: [Isoform 1]: Acts as a GEF (guanine nucleotide exchange factor) for unprenylated RHOA . Chaperones the entry and passage of small GTPases through the prenylation pathway . Recognizes the last amino acid in the GTPase C-terminal CAAX motif with a preference for 'Leu' over 'Met', indicating involvement in the geranylgeranylation pathway . .; FUNCTION: [Isoform 2]: Acts as a GEF (guanine nucleotide exchange factor) for prenylated RHOA . Acts as a GEF for RHOC . Chaperones the downstream trafficking and/or processing of small newly prenylated GTPases . Escorts RAC1 to the nucleus . . |
Accessions | ENST00000509011.5 D6RC12 D6RHH8 D6RHZ7 ENST00000511212.5 ENST00000510870.5 ENST00000339360.9 [P52306-5] ENST00000380158.8 [P52306-3] H0Y8M2 P52306 D6RB97 ENST00000503667.5 D6RBC6 ENST00000264572.11 [P52306-6] ENST00000408900.7 [P52306-2] ENST00000509501.5 ENST00000408927.8 [P52306-1] D6RC85 U3KQJ4 ENST00000514139.2 ENST00000514122.5 ENST00000508213.5 D6REZ0 ENST00000453712.6 [P52306-4] ENST00000508490.5 |