NET1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007165Biological processsignal transduction
GO_0051056Biological processregulation of small GTPase mediated signal transduction
GO_0035556Biological processintracellular signal transduction
GO_0051451Biological processmyoblast migration
GO_0035025Biological processpositive regulation of Rho protein signal transduction
GO_0071479Biological processcellular response to ionizing radiation
GO_0043065Biological processpositive regulation of apoptotic process
GO_0001558Biological processregulation of cell growth
GO_0043547Biological processpositive regulation of GTPase activity
GO_0070301Biological processcellular response to hydrogen peroxide
GO_0005829Cellular componentcytosol
GO_0005634Cellular componentnucleus
GO_0005085Molecular functionguanyl-nucleotide exchange factor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameNET1
Protein nameEpididymis secretory sperm binding protein (Neuroepithelial cell transforming gene 1, isoform CRA_b) (cDNA FLJ50843, highly similar to Neuroepithelial cell-transforming gene 1 protein)
Neuroepithelial cell transforming gene 1, isoform CRA_a (cDNA, FLJ96638, Homo sapiens neuroepithelial cell transforming gene 1 (NET1), mRNA)
Neuroepithelial cell transforming 1
NET1
Neuroepithelial cell-transforming gene 1 protein (Proto-oncogene p65 Net1) (Rho guanine nucleotide exchange factor 8)
SynonymsARHGEF8
hCG_19072
DescriptionFUNCTION: Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPase. May be involved in activation of the SAPK/JNK pathway Stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death. .

AccessionsENST00000380359.3 [Q7Z628-2]
Q5SQI5
ENST00000355029.9 [Q7Z628-1]
ENST00000449083.5
Q5SQI7
A0A2X0SFV4
Q5SQI6
Q7Z628