ANKRD27 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0035646Biological processendosome to melanosome transport
GO_0010976Biological processpositive regulation of neuron projection development
GO_0032456Biological processendocytic recycling
GO_0048812Biological processneuron projection morphogenesis
GO_0050775Biological processpositive regulation of dendrite morphogenesis
GO_0035544Biological processnegative regulation of SNARE complex assembly
GO_0015031Biological processprotein transport
GO_0045022Biological processearly endosome to late endosome transport
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0005769Cellular componentearly endosome
GO_0097422Cellular componenttubular endosome
GO_0005764Cellular componentlysosome
GO_0043005Cellular componentneuron projection
GO_0005829Cellular componentcytosol
GO_0005770Cellular componentlate endosome
GO_0030133Cellular componenttransport vesicle
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0042470Cellular componentmelanosome
GO_0030659Cellular componentcytoplasmic vesicle membrane
GO_0005085Molecular functionguanyl-nucleotide exchange factor activity
GO_0031267Molecular functionsmall GTPase binding
GO_0005096Molecular functionGTPase activator activity
GO_0000149Molecular functionSNARE binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameANKRD27
Protein nameAnkyrin repeat domain 27
Ankyrin repeat domain-containing protein 27 (VPS9 domain-containing protein)
SynonymsPP12899
DescriptionFUNCTION: May be a guanine exchange factor (GEF) for Rab21, Rab32 and Rab38 and regulate endosome dynamics . May regulate the participation of VAMP7 in membrane fusion events; in vitro inhibits VAMP7-mediated SNARE complex formation by trapping VAMP7 in a closed, fusogenically inactive conformation . Involved in peripheral melanosomal distribution of TYRP1 in melanocytes; the function, which probably is implicating vesicle-trafficking, includes cooperation with Rab32, Rab38 and VAMP7 (By similarity). Involved in the regulation of neurite growth; the function seems to require its GEF activity, probably towards Rab21, and VAMP7 but not Rab32/38 (By similarity). Proposed to be involved in Golgi sorting of VAMP7 and transport of VAMP7 vesicles to the cell surface; the function seems to implicate kinesin heavy chain isoform 5 proteins, GOLGA4, RAB21 and MACF1 . Required for the colocalization of VAMP7 and Rab21, probably on TGN sites . Involved in GLUT1 endosome-to-plasma membrane trafficking; the function is dependent of association with VPS29 . Regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes (By similarity). .

AccessionsENST00000586463.5
K7EIN0
ENST00000587352.5
K7ENE0
K7ELM1
K7EPM2
ENST00000588700.5
Q96NW4
ENST00000306065.9
ENST00000590519.2
V9GYL8
K7EIH4
ENST00000586693.7
ENST00000591100.6