Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| epithelial cell | 6 studies | 35% ± 11% | |
| respiratory goblet cell | 5 studies | 28% ± 9% | |
| ciliated cell | 5 studies | 22% ± 6% | |
| secretory cell | 5 studies | 26% ± 7% | |
| squamous epithelial cell | 4 studies | 71% ± 18% | |
| mesothelial cell | 4 studies | 33% ± 13% | |
| basal cell | 4 studies | 28% ± 10% | |
| club cell | 3 studies | 26% ± 10% |
Insufficient scRNA-seq data for expression of EPS8L1 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| thymus | 100% | 5350.75 | 650 / 653 | 85% | 39.65 | 513 / 605 |
| prostate | 85% | 2764.81 | 209 / 245 | 97% | 30.51 | 489 / 502 |
| stomach | 72% | 2258.14 | 258 / 359 | 88% | 24.41 | 252 / 286 |
| lung | 71% | 1029.55 | 409 / 578 | 78% | 21.73 | 901 / 1155 |
| pancreas | 54% | 804.27 | 178 / 328 | 92% | 75.90 | 163 / 178 |
| breast | 53% | 1331.75 | 245 / 459 | 89% | 26.85 | 999 / 1118 |
| kidney | 96% | 2874.80 | 85 / 89 | 36% | 10.37 | 323 / 901 |
| esophagus | 41% | 12582.32 | 592 / 1445 | 83% | 35.21 | 151 / 183 |
| intestine | 23% | 357.90 | 218 / 966 | 94% | 27.25 | 497 / 527 |
| bladder | 24% | 464.71 | 5 / 21 | 88% | 36.80 | 444 / 504 |
| skin | 72% | 10953.34 | 1305 / 1809 | 36% | 5.14 | 170 / 472 |
| ovary | 4% | 53.21 | 7 / 180 | 98% | 59.02 | 423 / 430 |
| uterus | 11% | 618.54 | 19 / 170 | 84% | 47.46 | 384 / 459 |
| tonsil | 0% | 0 | 0 / 0 | 84% | 28.90 | 38 / 45 |
| eye | 0% | 0 | 0 / 0 | 54% | 5.31 | 43 / 80 |
| adipose | 23% | 583.02 | 279 / 1204 | 0% | 0 | 0 / 0 |
| liver | 0% | 0 | 0 / 226 | 14% | 5.75 | 58 / 406 |
| adrenal gland | 0% | 0 | 0 / 258 | 3% | 0.30 | 6 / 230 |
| heart | 2% | 34.10 | 20 / 861 | 0% | 0 | 0 / 0 |
| blood vessel | 0% | 9.39 | 6 / 1335 | 0% | 0 | 0 / 0 |
| spleen | 0% | 8.18 | 1 / 241 | 0% | 0 | 0 / 0 |
| brain | 0% | 0 | 0 / 2642 | 0% | 0.03 | 2 / 705 |
| muscle | 0% | 3.96 | 2 / 803 | 0% | 0 | 0 / 0 |
| peripheral blood | 0% | 4.76 | 2 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0007266 | Biological process | Rho protein signal transduction |
| GO_1900029 | Biological process | positive regulation of ruffle assembly |
| GO_0035023 | Biological process | regulation of Rho protein signal transduction |
| GO_0032587 | Cellular component | ruffle membrane |
| GO_0070062 | Cellular component | extracellular exosome |
| GO_0032991 | Cellular component | protein-containing complex |
| GO_0005829 | Cellular component | cytosol |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0045296 | Molecular function | cadherin binding |
| GO_0042608 | Molecular function | T cell receptor binding |
| GO_0005085 | Molecular function | guanyl-nucleotide exchange factor activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0003779 | Molecular function | actin binding |
| Gene name | EPS8L1 |
| Protein name | EPS8 like 1 (EPS8-like 1, isoform CRA_d) Epidermal growth factor receptor kinase substrate 8-like protein 1 (EPS8-like protein 1) (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-related protein 1) EPS8 like 1 (cDNA FLJ60287, highly similar to Epidermal growth factor receptor kinase substrate 8-like protein 1) EPS8 like 1 |
| Synonyms | DRC3 hCG_20264 EPS8R1 PP10566 |
| Description | FUNCTION: Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton. . |
| Accessions | K7EKX9 K7EN83 Q8TE68 K7ELW3 ENST00000587786.5 ENST00000588359.5 ENST00000586329.5 B4DKV7 ENST00000540810.5 ENST00000201647.11 [Q8TE68-1] ENST00000245618.5 [Q8TE68-2] |
