MADD report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0097194Biological processexecution phase of apoptosis
GO_0032483Biological processregulation of Rab protein signal transduction
GO_0042981Biological processregulation of apoptotic process
GO_1902041Biological processregulation of extrinsic apoptotic signaling pathway via death domain receptors
GO_0043410Biological processpositive regulation of MAPK cascade
GO_2001236Biological processregulation of extrinsic apoptotic signaling pathway
GO_0051726Biological processregulation of cell cycle
GO_0007166Biological processcell surface receptor signaling pathway
GO_0030424Cellular componentaxon
GO_0005829Cellular componentcytosol
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0005737Cellular componentcytoplasm
GO_0005123Molecular functiondeath receptor binding
GO_0030295Molecular functionprotein kinase activator activity
GO_0005085Molecular functionguanyl-nucleotide exchange factor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMADD
Protein nameMAP kinase-activating death domain protein (Differentially expressed in normal and neoplastic cells) (Insulinoma glucagonoma clone 20) (Rab3 GDP/GTP exchange factor) (RabGEF) (Rab3 GDP/GTP exchange protein) (Rab3GEP)
MAP kinase-activating death domain protein
MAP kinase activating death domain
SynonymsIG20
DENN
KIAA0358
DescriptionFUNCTION: Guanyl-nucleotide exchange factor that regulates small GTPases of the Rab family . Converts GDP-bound inactive form of RAB27A and RAB27B to the GTP-bound active forms . Converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms, GTPases involved in synaptic vesicle exocytosis and vesicle secretion (By similarity). Plays a role in synaptic vesicle formation and in vesicle trafficking at the neuromuscular junction (By similarity). Involved in up-regulating a post-docking step of synaptic exocytosis in central synapses (By similarity). Probably by binding to the motor proteins KIF1B and KIF1A, mediates motor-dependent transport of GTP-RAB3A-positive vesicles to the presynaptic nerve terminals (By similarity). Plays a role in TNFA-mediated activation of the MAPK pathway, including ERK1/2 . May link TNFRSF1A with MAP kinase activation . May be involved in the regulation of TNFA-induced apoptosis . .

AccessionsENST00000395336.7 [Q8WXG6-7]
ENST00000706886.1
ENST00000406482.5 [Q8WXG6-6]
ENST00000342922.8
ENST00000422579.1
A0A0U1RR25
ENST00000402192.6 [Q8WXG6-3]
A0A9L9PXZ3
A0A9L9PY18
ENST00000453571.5
ENST00000349238.7 [Q8WXG6-2]
A0A9L9PY22
ENST00000706887.1
ENST00000311027.9 [Q8WXG6-1]
ENST00000706891.1
Q8WXG6
ENST00000395344.7 [Q8WXG6-8]
ENST00000407859.7 [Q8WXG6-4]
ENST00000402799.5 [Q8WXG6-5]
A0A9L9PXN0
A0A9L9PYF5
ENST00000634938.2
ENST00000706890.1
A0A0A0MRB5
ENST00000526603.6
C9K0L0
C9JLZ9
A0A9L9PXF1
ENST00000706888.1
ENST00000428807.5
C9J6B0
ENST00000444117.5
A0A9L9PXZ0
ENST00000706889.1
C9JM97