Name | Number of supported studies | Average coverage | |
---|---|---|---|
amacrine cell | 6 studies | 24% ± 6% | |
retinal cone cell | 6 studies | 25% ± 6% | |
endothelial cell | 5 studies | 29% ± 11% | |
glutamatergic neuron | 5 studies | 44% ± 22% | |
retina horizontal cell | 5 studies | 25% ± 7% | |
neuron | 4 studies | 22% ± 6% | |
interneuron | 4 studies | 35% ± 21% | |
GABAergic neuron | 4 studies | 40% ± 15% | |
astrocyte | 4 studies | 21% ± 5% | |
macrophage | 4 studies | 18% ± 2% | |
CD16-positive, CD56-dim natural killer cell, human | 3 studies | 18% ± 2% | |
granule cell | 3 studies | 20% ± 3% | |
microglial cell | 3 studies | 20% ± 3% | |
retinal ganglion cell | 3 studies | 44% ± 13% | |
retinal rod cell | 3 studies | 22% ± 5% | |
natural killer cell | 3 studies | 18% ± 1% | |
oligodendrocyte | 3 studies | 22% ± 3% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 3695.55 | 1445 / 1445 | 100% | 25.80 | 183 / 183 |
prostate | 100% | 6283.96 | 245 / 245 | 100% | 32.01 | 502 / 502 |
stomach | 100% | 3941.77 | 359 / 359 | 100% | 25.67 | 286 / 286 |
intestine | 100% | 4994.49 | 966 / 966 | 100% | 25.10 | 526 / 527 |
breast | 100% | 4424.25 | 459 / 459 | 100% | 32.25 | 1115 / 1118 |
bladder | 100% | 5207.67 | 21 / 21 | 100% | 24.84 | 502 / 504 |
skin | 100% | 5041.72 | 1809 / 1809 | 100% | 34.99 | 470 / 472 |
adrenal gland | 100% | 6262.38 | 258 / 258 | 100% | 58.18 | 229 / 230 |
uterus | 100% | 4602.73 | 170 / 170 | 100% | 21.99 | 457 / 459 |
brain | 100% | 11420.48 | 2636 / 2642 | 100% | 49.91 | 703 / 705 |
thymus | 100% | 4397.85 | 653 / 653 | 99% | 21.17 | 600 / 605 |
lung | 100% | 5408.13 | 578 / 578 | 99% | 22.44 | 1140 / 1155 |
kidney | 100% | 3933.54 | 89 / 89 | 98% | 19.98 | 887 / 901 |
pancreas | 99% | 2366.20 | 324 / 328 | 99% | 28.88 | 177 / 178 |
liver | 98% | 1979.28 | 222 / 226 | 95% | 12.64 | 384 / 406 |
ovary | 100% | 4944.31 | 180 / 180 | 92% | 14.86 | 397 / 430 |
adipose | 100% | 4215.17 | 1204 / 1204 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 100% | 30.62 | 80 / 80 |
lymph node | 0% | 0 | 0 / 0 | 100% | 30.35 | 29 / 29 |
spleen | 100% | 6315.07 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 24.43 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 8.78 | 1 / 1 |
blood vessel | 100% | 3798.40 | 1334 / 1335 | 0% | 0 | 0 / 0 |
muscle | 100% | 4110.62 | 800 / 803 | 0% | 0 | 0 / 0 |
heart | 98% | 4160.21 | 846 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 94% | 3288.46 | 869 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0097194 | Biological process | execution phase of apoptosis |
GO_0032483 | Biological process | regulation of Rab protein signal transduction |
GO_0042981 | Biological process | regulation of apoptotic process |
GO_1902041 | Biological process | regulation of extrinsic apoptotic signaling pathway via death domain receptors |
GO_0043410 | Biological process | positive regulation of MAPK cascade |
GO_2001236 | Biological process | regulation of extrinsic apoptotic signaling pathway |
GO_0051726 | Biological process | regulation of cell cycle |
GO_0007166 | Biological process | cell surface receptor signaling pathway |
GO_0030424 | Cellular component | axon |
GO_0005829 | Cellular component | cytosol |
GO_0005886 | Cellular component | plasma membrane |
GO_0016020 | Cellular component | membrane |
GO_0005737 | Cellular component | cytoplasm |
GO_0005123 | Molecular function | death receptor binding |
GO_0030295 | Molecular function | protein kinase activator activity |
GO_0005085 | Molecular function | guanyl-nucleotide exchange factor activity |
GO_0005515 | Molecular function | protein binding |
Gene name | MADD |
Protein name | MAP kinase-activating death domain protein (Differentially expressed in normal and neoplastic cells) (Insulinoma glucagonoma clone 20) (Rab3 GDP/GTP exchange factor) (RabGEF) (Rab3 GDP/GTP exchange protein) (Rab3GEP) MAP kinase-activating death domain protein MAP kinase activating death domain |
Synonyms | IG20 DENN KIAA0358 |
Description | FUNCTION: Guanyl-nucleotide exchange factor that regulates small GTPases of the Rab family . Converts GDP-bound inactive form of RAB27A and RAB27B to the GTP-bound active forms . Converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms, GTPases involved in synaptic vesicle exocytosis and vesicle secretion (By similarity). Plays a role in synaptic vesicle formation and in vesicle trafficking at the neuromuscular junction (By similarity). Involved in up-regulating a post-docking step of synaptic exocytosis in central synapses (By similarity). Probably by binding to the motor proteins KIF1B and KIF1A, mediates motor-dependent transport of GTP-RAB3A-positive vesicles to the presynaptic nerve terminals (By similarity). Plays a role in TNFA-mediated activation of the MAPK pathway, including ERK1/2 . May link TNFRSF1A with MAP kinase activation . May be involved in the regulation of TNFA-induced apoptosis . . |
Accessions | ENST00000395336.7 [Q8WXG6-7] ENST00000706886.1 ENST00000406482.5 [Q8WXG6-6] ENST00000342922.8 ENST00000422579.1 A0A0U1RR25 ENST00000402192.6 [Q8WXG6-3] A0A9L9PXZ3 A0A9L9PY18 ENST00000453571.5 ENST00000349238.7 [Q8WXG6-2] A0A9L9PY22 ENST00000706887.1 ENST00000311027.9 [Q8WXG6-1] ENST00000706891.1 Q8WXG6 ENST00000395344.7 [Q8WXG6-8] ENST00000407859.7 [Q8WXG6-4] ENST00000402799.5 [Q8WXG6-5] A0A9L9PXN0 A0A9L9PYF5 ENST00000634938.2 ENST00000706890.1 A0A0A0MRB5 ENST00000526603.6 C9K0L0 C9JLZ9 A0A9L9PXF1 ENST00000706888.1 ENST00000428807.5 C9J6B0 ENST00000444117.5 A0A9L9PXZ0 ENST00000706889.1 C9JM97 |