SBF2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006914Biological processautophagy
GO_0042552Biological processmyelination
GO_0005774Cellular componentvacuolar membrane
GO_0010008Cellular componentendosome membrane
GO_0030424Cellular componentaxon
GO_0005829Cellular componentcytosol
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0016020Cellular componentmembrane
GO_0005737Cellular componentcytoplasm
GO_0005085Molecular functionguanyl-nucleotide exchange factor activity
GO_0019902Molecular functionphosphatase binding
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding
GO_0035091Molecular functionphosphatidylinositol binding
GO_0019208Molecular functionphosphatase regulator activity

IV. Literature review

[source]
Gene nameSBF2
Protein nameSET binding factor 2
Myotubularin-related protein 13 (Inactive phosphatidylinositol 3-phosphatase 13) (SET-binding factor 2)
SynonymsMTMR13
CMT4B2
KIAA1766
DescriptionFUNCTION: Guanine nucleotide exchange factor (GEF) which activates RAB21 and possibly RAB28 . Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form . In response to starvation-induced autophagy, activates RAB21 which in turn binds to and regulates SNARE protein VAMP8 endolysosomal transport required for SNARE-mediated autophagosome-lysosome fusion . Acts as an adapter for the phosphatase MTMR2 (By similarity). Increases MTMR2 catalytic activity towards phosphatidylinositol 3,5-bisphosphate and to a lesser extent towards phosphatidylinositol 3-phosphate (By similarity). .

AccessionsA0A8I5KQC6
ENST00000692068.1
A0A8I5KT92
A0A8I5KTA9
ENST00000690944.1
ENST00000689597.1
ENST00000533770.6 [Q86WG5-3]
A0A6Q8PH13
ENST00000690003.1
ENST00000689342.1
ENST00000687256.1
ENST00000420722.3
ENST00000675281.2
ENST00000689128.1
ENST00000687300.1
A0A8I5KWU9
ENST00000256190.13 [Q86WG5-1]
ENST00000688739.1
Q86WG5
A0A8I5KWJ6
A0A8I5KUI7
A0A6Q8PHP8
A0A8I5KT45
H0YD05
ENST00000688206.1
ENST00000693181.1
A0A8I5KNS4
A0A8I5KY55
A0A8I5KTX3
ENST00000676387.2
ENST00000688344.1
ENST00000689940.1
A0A8I5QJN8
A0A8I5KQ02
A0A8I5KUI9
ENST00000692716.1
ENST00000689674.1
A0A8I5KRQ5
A0A8I5KSD8
A0A6Q8PH87
ENST00000686079.1
ENST00000693212.1
A0A8I5QL20
ENST00000693022.1
A0A8I5KVJ0
ENST00000690234.1
A0A8I5QKS9
H0Y767
ENST00000689258.1
A0A8I5KXJ7
A0A8I5KWY5
A0A8I5KUN8
ENST00000525040.5
ENST00000687210.1
ENST00000530741.2
ENST00000693201.1
A0A8I5KRP8
ENST00000690806.1
ENST00000676324.2