Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 17 studies | 26% ± 11% | |
macrophage | 14 studies | 29% ± 18% | |
microglial cell | 14 studies | 48% ± 21% | |
type I pneumocyte | 10 studies | 48% ± 13% | |
non-classical monocyte | 9 studies | 27% ± 14% | |
classical monocyte | 9 studies | 24% ± 11% | |
myeloid cell | 7 studies | 28% ± 11% | |
dendritic cell | 6 studies | 24% ± 13% | |
monocyte | 6 studies | 26% ± 7% | |
pericyte | 6 studies | 23% ± 13% | |
B cell | 5 studies | 22% ± 3% | |
neutrophil | 4 studies | 28% ± 5% | |
endothelial cell of artery | 4 studies | 22% ± 4% | |
glutamatergic neuron | 4 studies | 44% ± 20% | |
CD16-positive, CD56-dim natural killer cell, human | 3 studies | 19% ± 1% | |
conventional dendritic cell | 3 studies | 28% ± 15% | |
hematopoietic precursor cell | 3 studies | 27% ± 15% | |
capillary endothelial cell | 3 studies | 17% ± 1% | |
glomerular endothelial cell | 3 studies | 30% ± 8% | |
naive B cell | 3 studies | 17% ± 1% | |
memory B cell | 3 studies | 18% ± 1% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
thymus | 100% | 5205.27 | 651 / 653 | 99% | 6.81 | 601 / 605 |
prostate | 100% | 4339.89 | 244 / 245 | 98% | 5.88 | 490 / 502 |
lung | 100% | 14570.94 | 578 / 578 | 97% | 8.48 | 1122 / 1155 |
intestine | 100% | 7201.59 | 965 / 966 | 97% | 5.86 | 509 / 527 |
kidney | 98% | 4540.71 | 87 / 89 | 96% | 11.75 | 866 / 901 |
breast | 99% | 6707.53 | 456 / 459 | 92% | 4.92 | 1023 / 1118 |
uterus | 99% | 5100.55 | 169 / 170 | 88% | 4.86 | 403 / 459 |
stomach | 91% | 2997.25 | 328 / 359 | 96% | 6.03 | 274 / 286 |
bladder | 100% | 2905.90 | 21 / 21 | 82% | 4.64 | 414 / 504 |
ovary | 96% | 3353.21 | 173 / 180 | 79% | 4.07 | 338 / 430 |
esophagus | 82% | 3472.84 | 1188 / 1445 | 91% | 6.63 | 167 / 183 |
brain | 69% | 2382.35 | 1816 / 2642 | 99% | 9.84 | 697 / 705 |
adrenal gland | 88% | 2037.87 | 227 / 258 | 70% | 3.77 | 162 / 230 |
skin | 67% | 2168.55 | 1209 / 1809 | 70% | 3.56 | 329 / 472 |
pancreas | 21% | 399.88 | 68 / 328 | 97% | 10.43 | 173 / 178 |
adipose | 100% | 8900.97 | 1204 / 1204 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 25.49 | 29 / 29 |
spleen | 100% | 11383.27 | 241 / 241 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 6.01 | 1 / 1 |
blood vessel | 100% | 8090.72 | 1334 / 1335 | 0% | 0 | 0 / 0 |
peripheral blood | 100% | 22830.50 | 928 / 929 | 0% | 0 | 0 / 0 |
heart | 96% | 2904.60 | 823 / 861 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 96% | 7.50 | 43 / 45 |
muscle | 63% | 1514.55 | 507 / 803 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 57% | 3.09 | 46 / 80 |
liver | 15% | 281.90 | 34 / 226 | 33% | 1.41 | 134 / 406 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0008333 | Biological process | endosome to lysosome transport |
GO_0032483 | Biological process | regulation of Rab protein signal transduction |
GO_0030163 | Biological process | protein catabolic process |
GO_0005829 | Cellular component | cytosol |
GO_0031410 | Cellular component | cytoplasmic vesicle |
GO_0005085 | Molecular function | guanyl-nucleotide exchange factor activity |
Gene name | DENND3 |
Protein name | DENN domain-containing protein 3 DENN domain containing 3 (DENN/MADD domain containing 3, isoform CRA_d) (cDNA FLJ34237 fis, clone FCBBF3027328) DENN domain containing 3 Alternative protein DENND3 |
Synonyms | hCG_20740 KIAA0870 |
Description | FUNCTION: Guanine nucleotide exchange factor (GEF) activating RAB12. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB12 into its active GTP-bound form . Regulates autophagy in response to starvation through RAB12 activation. Starvation leads to ULK1/2-dependent phosphorylation of Ser-472 and Ser-490, which in turn allows recruitment of 14-3-3 adapter proteins and leads to up-regulation of GEF activity towards RAB12 (By similarity). Also plays a role in protein transport from recycling endosomes to lysosomes, regulating, for instance, the degradation of the transferrin receptor and of the amino acid transporter PAT4 . Starvation also induces phosphorylation at Tyr-858, which leads to up-regulated GEF activity and initiates autophagy (By similarity). . |
Accessions | ENST00000518198.1 H0YAW2 ENST00000424248.2 [A2RUS2-2] E5RI43 H0YAY3 ENST00000523308.5 E5RH95 E5RJ42 E5RHH2 H0YBK9 A2RUS2 ENST00000519811.6 ENST00000517985.5 E9PF32 ENST00000520986.5 ENST00000519291.5 ENST00000262585.6 [A2RUS2-1] L8E848 ENST00000518249.5 ENST00000520725.5 ENST00000518347.5 H0YBH5 B3KRG7 ENST00000523058.5 E5RIR7 ENST00000518668.5 |