DENND3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0008333Biological processendosome to lysosome transport
GO_0032483Biological processregulation of Rab protein signal transduction
GO_0030163Biological processprotein catabolic process
GO_0005829Cellular componentcytosol
GO_0031410Cellular componentcytoplasmic vesicle
GO_0005085Molecular functionguanyl-nucleotide exchange factor activity

IV. Literature review

[source]
Gene nameDENND3
Protein nameDENN domain-containing protein 3
DENN domain containing 3 (DENN/MADD domain containing 3, isoform CRA_d) (cDNA FLJ34237 fis, clone FCBBF3027328)
DENN domain containing 3
Alternative protein DENND3
SynonymshCG_20740
KIAA0870
DescriptionFUNCTION: Guanine nucleotide exchange factor (GEF) activating RAB12. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB12 into its active GTP-bound form . Regulates autophagy in response to starvation through RAB12 activation. Starvation leads to ULK1/2-dependent phosphorylation of Ser-472 and Ser-490, which in turn allows recruitment of 14-3-3 adapter proteins and leads to up-regulation of GEF activity towards RAB12 (By similarity). Also plays a role in protein transport from recycling endosomes to lysosomes, regulating, for instance, the degradation of the transferrin receptor and of the amino acid transporter PAT4 . Starvation also induces phosphorylation at Tyr-858, which leads to up-regulated GEF activity and initiates autophagy (By similarity). .

AccessionsENST00000518198.1
H0YAW2
ENST00000424248.2 [A2RUS2-2]
E5RI43
H0YAY3
ENST00000523308.5
E5RH95
E5RJ42
E5RHH2
H0YBK9
A2RUS2
ENST00000519811.6
ENST00000517985.5
E9PF32
ENST00000520986.5
ENST00000519291.5
ENST00000262585.6 [A2RUS2-1]
L8E848
ENST00000518249.5
ENST00000520725.5
ENST00000518347.5
H0YBH5
B3KRG7
ENST00000523058.5
E5RIR7
ENST00000518668.5