ELMO1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	36 studies	45% ± 20%	Explore
macrophage	22 studies	46% ± 26%	Explore
B cell	20 studies	30% ± 17%	Explore
oligodendrocyte	17 studies	79% ± 22%	Explore
mast cell	16 studies	50% ± 25%	Explore
oligodendrocyte precursor cell	16 studies	46% ± 16%	Explore
microglial cell	16 studies	75% ± 19%	Explore
CD4-positive, alpha-beta T cell	13 studies	26% ± 14%	Explore
memory B cell	13 studies	20% ± 3%	Explore
dendritic cell	13 studies	45% ± 24%	Explore
glutamatergic neuron	12 studies	48% ± 23%	Explore
fibroblast	12 studies	40% ± 14%	Explore
GABAergic neuron	11 studies	43% ± 14%	Explore
endothelial cell of lymphatic vessel	10 studies	57% ± 22%	Explore
T cell	10 studies	31% ± 16%	Explore
endothelial cell of artery	9 studies	36% ± 21%	Explore
vein endothelial cell	9 studies	42% ± 29%	Explore
myeloid cell	9 studies	50% ± 24%	Explore
regulatory T cell	9 studies	26% ± 12%	Explore
capillary endothelial cell	8 studies	32% ± 15%	Explore
CD8-positive, alpha-beta T cell	8 studies	25% ± 12%	Explore
conventional dendritic cell	7 studies	30% ± 12%	Explore
hematopoietic stem cell	7 studies	35% ± 12%	Explore
plasmacytoid dendritic cell	7 studies	23% ± 6%	Explore
astrocyte	6 studies	44% ± 15%	Explore
neuron	6 studies	39% ± 17%	Explore
interneuron	6 studies	43% ± 9%	Explore
naive B cell	6 studies	23% ± 4%	Explore
T follicular helper cell	6 studies	21% ± 4%	Explore
mucosal invariant T cell	5 studies	25% ± 13%	Explore
CD16-positive, CD56-dim natural killer cell, human	5 studies	23% ± 12%	Explore
effector memory CD8-positive, alpha-beta T cell	5 studies	28% ± 13%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	5 studies	30% ± 16%	Explore
monocyte	5 studies	62% ± 9%	Explore
leukocyte	5 studies	60% ± 23%	Explore
natural killer cell	5 studies	35% ± 12%	Explore
hematopoietic precursor cell	4 studies	47% ± 22%	Explore
CD4-positive, alpha-beta memory T cell	4 studies	21% ± 4%	Explore
classical monocyte	4 studies	22% ± 3%	Explore
granule cell	4 studies	40% ± 7%	Explore
retinal ganglion cell	4 studies	29% ± 13%	Explore
plasma cell	4 studies	45% ± 15%	Explore
endothelial cell of vascular tree	4 studies	64% ± 26%	Explore
CD8-positive, alpha-beta memory T cell	4 studies	21% ± 5%	Explore
endothelial cell of sinusoid	3 studies	34% ± 14%	Explore
smooth muscle cell	3 studies	29% ± 10%	Explore
pericyte	3 studies	31% ± 18%	Explore
GABAergic interneuron	3 studies	30% ± 7%	Explore
glial cell	3 studies	62% ± 10%	Explore
progenitor cell	3 studies	39% ± 23%	Explore
endocardial cell	3 studies	52% ± 23%	Explore
mononuclear phagocyte	3 studies	45% ± 13%	Explore
non-classical monocyte	3 studies	23% ± 8%	Explore
GABAergic amacrine cell	3 studies	31% ± 12%	Explore
glycinergic amacrine cell	3 studies	33% ± 10%	Explore
hepatocyte	3 studies	70% ± 19%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	19% ± 3%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	52% ± 25%	Explore
alveolar macrophage	3 studies	65% ± 9%	Explore
lymphocyte	3 studies	54% ± 7%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	3 studies	27% ± 14%	Explore
mural cell	3 studies	37% ± 9%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	19 studies	50% ± 20%	Explore
peripheral blood	5 studies	18% ± 2%	Explore
lung	5 studies	28% ± 12%	Explore
heart	4 studies	26% ± 8%	Explore
liver	3 studies	39% ± 17%	Explore
adipose	3 studies	27% ± 9%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	99%	7600.90	2626 / 2642	100%	47.98	704 / 705
thymus	100%	6820.84	652 / 653	93%	17.47	562 / 605
breast	100%	2750.70	457 / 459	89%	7.48	997 / 1118
lung	100%	3384.08	576 / 578	88%	8.14	1014 / 1155
liver	77%	953.78	173 / 226	92%	10.06	375 / 406
ovary	93%	1348.73	167 / 180	72%	5.69	309 / 430
esophagus	70%	1181.37	1013 / 1445	82%	8.71	150 / 183
prostate	82%	1203.43	202 / 245	55%	2.84	278 / 502
bladder	86%	1340.90	18 / 21	49%	3.52	249 / 504
intestine	83%	1433.35	801 / 966	52%	3.93	274 / 527
uterus	81%	1094.55	138 / 170	44%	2.86	202 / 459
skin	48%	604.61	872 / 1809	64%	7.03	302 / 472
stomach	41%	510.06	146 / 359	67%	5.33	193 / 286
adrenal gland	23%	238.88	59 / 258	82%	14.01	189 / 230
lymph node	0%	0	0 / 0	100%	24.83	29 / 29
spleen	100%	5660.90	241 / 241	0%	0	0 / 0
adipose	100%	3375.85	1203 / 1204	0%	0	0 / 0
kidney	27%	308.69	24 / 89	72%	10.22	653 / 901
peripheral blood	98%	4211.32	913 / 929	0%	0	0 / 0
pancreas	13%	142.72	43 / 328	85%	8.78	151 / 178
heart	77%	979.01	667 / 861	0%	0	0 / 0
blood vessel	66%	1005.03	880 / 1335	0%	0	0 / 0
tonsil	0%	0	0 / 0	64%	4.60	29 / 45
eye	0%	0	0 / 0	14%	0.68	11 / 80
muscle	11%	116.59	91 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0006915	Biological process	apoptotic process
GO_0007015	Biological process	actin filament organization
GO_0048870	Biological process	cell motility
GO_0030036	Biological process	actin cytoskeleton organization
GO_0016601	Biological process	Rac protein signal transduction
GO_0006911	Biological process	phagocytosis, engulfment
GO_0005829	Cellular component	cytosol
GO_0032045	Cellular component	guanyl-nucleotide exchange factor complex
GO_0005886	Cellular component	plasma membrane
GO_0016020	Cellular component	membrane
GO_0005737	Cellular component	cytoplasm
GO_0005085	Molecular function	guanyl-nucleotide exchange factor activity
GO_0005515	Molecular function	protein binding
GO_0017124	Molecular function	SH3 domain binding

IV. Literature review

[source]

Gene name	ELMO1
Protein name	Engulfment and cell motility 1 Engulfment and cell motility protein 1 (Protein ced-12 homolog) Engulfment and cell motility 1 (Ced-12 homolog, C. elegans) (Engulfment and cell motility 1, isoform CRA_c) (cDNA FLJ77700, highly similar to Homo sapiens engulfment and cell motility 1 (ELMO1), transcript variant 1, mRNA)
Synonyms	hCG_18181 KIAA0281 tcag7.471
Description	FUNCTION: Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1. . FUNCTION: Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1. .
Accessions	H7C0N5 ENST00000455879.5 ENST00000455119.5 ENST00000310758.9 [Q92556-1] C9JB20 ENST00000420636.5 ENST00000396045.7 [Q92556-2] C9IZR8 ENST00000396040.6 [Q92556-2] C9JIW2 ENST00000445322.1 ENST00000453399.5 ENST00000424212.1 C9J5X3 ENST00000448602.5 [Q92556-1] H7C3P3 ENST00000442504.5 [Q92556-1] Q92556 A4D1X5 H7C0S6 ENST00000433246.5

ELMO1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review