THG1L | OmnibusX

Name	Number of supported studies	Average coverage
epithelial cell	4 studies	26% ± 9%	Explore
dendritic cell	3 studies	24% ± 1%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of THG1L at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	849.63	1445 / 1445	100%	11.53	183 / 183
intestine	100%	1066.58	966 / 966	100%	24.95	527 / 527
prostate	100%	758.13	245 / 245	100%	16.75	502 / 502
thymus	100%	807.51	653 / 653	100%	22.84	605 / 605
uterus	100%	989.75	170 / 170	100%	19.73	459 / 459
breast	100%	670.01	459 / 459	100%	16.55	1116 / 1118
bladder	100%	1135.14	21 / 21	100%	18.94	503 / 504
ovary	100%	870.82	180 / 180	100%	15.13	429 / 430
lung	100%	571.98	577 / 578	100%	12.93	1153 / 1155
stomach	100%	760.82	359 / 359	100%	19.03	285 / 286
skin	100%	886.11	1809 / 1809	100%	17.20	470 / 472
liver	100%	365.43	226 / 226	99%	10.29	403 / 406
adrenal gland	100%	840.02	258 / 258	99%	15.10	228 / 230
pancreas	98%	521.87	323 / 328	100%	16.78	178 / 178
kidney	100%	473.38	89 / 89	98%	17.13	885 / 901
brain	95%	249.47	2504 / 2642	100%	12.91	705 / 705
adipose	100%	680.34	1204 / 1204	0%	0	0 / 0
blood vessel	100%	621.47	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	31.28	29 / 29
spleen	100%	589.63	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	19.10	45 / 45
ureter	0%	0	0 / 0	100%	3.38	1 / 1
eye	0%	0	0 / 0	99%	19.55	79 / 80
muscle	98%	405.59	789 / 803	0%	0	0 / 0
heart	96%	366.36	823 / 861	0%	0	0 / 0
peripheral blood	82%	519.64	764 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_1990046	Biological process	stress-induced mitochondrial fusion
GO_0008053	Biological process	mitochondrial fusion
GO_0099116	Biological process	tRNA 5'-end processing
GO_0006400	Biological process	tRNA modification
GO_0008033	Biological process	tRNA processing
GO_0006979	Biological process	response to oxidative stress
GO_0051289	Biological process	protein homotetramerization
GO_0005739	Cellular component	mitochondrion
GO_0005829	Cellular component	cytosol
GO_1990234	Cellular component	transferase complex
GO_0005741	Cellular component	mitochondrial outer membrane
GO_0016779	Molecular function	nucleotidyltransferase activity
GO_0005085	Molecular function	guanyl-nucleotide exchange factor activity
GO_0042802	Molecular function	identical protein binding
GO_0000287	Molecular function	magnesium ion binding
GO_0005525	Molecular function	GTP binding
GO_0005524	Molecular function	ATP binding
GO_0008193	Molecular function	tRNA guanylyltransferase activity
GO_0000049	Molecular function	tRNA binding
GO_0005515	Molecular function	protein binding

Gene name	THG1L
Protein name	Probable tRNA(His) guanylyltransferase Probable tRNA(His) guanylyltransferase (EC 2.7.7.79) (Induced in high glucose-1) (IHG-1) (Interphase cytoplasmic foci protein 45) (tRNA-histidine guanylyltransferase) tRNA-histidine guanylyltransferase 1 like
Synonyms	ICF45
Description	FUNCTION: Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. This step is essential for proper recognition of the tRNA and for the fidelity of protein synthesis (Probable). Also functions as a guanyl-nucleotide exchange factor/GEF for the MFN1 and MFN2 mitofusins thereby regulating mitochondrial fusion . By regulating both mitochondrial dynamics and bioenergetic function, it contributes to cell survival following oxidative stress . .
Accessions	H0YC78 E5RIQ8 ENST00000523575.1 ENST00000231198.12 Q9NWX6 ENST00000521655.1

THG1L report