ITSN1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051056Biological processregulation of small GTPase mediated signal transduction
GO_0035556Biological processintracellular signal transduction
GO_0016197Biological processendosomal transport
GO_0006887Biological processexocytosis
GO_0150007Biological processclathrin-dependent synaptic vesicle endocytosis
GO_0015031Biological processprotein transport
GO_0008104Biological processprotein localization
GO_0005886Cellular componentplasma membrane
GO_0055037Cellular componentrecycling endosome
GO_0097708Cellular componentintracellular vesicle
GO_0043005Cellular componentneuron projection
GO_0005635Cellular componentnuclear envelope
GO_0042734Cellular componentpresynaptic membrane
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005905Cellular componentclathrin-coated pit
GO_0030027Cellular componentlamellipodium
GO_0005085Molecular functionguanyl-nucleotide exchange factor activity
GO_0060090Molecular functionmolecular adaptor activity
GO_0070064Molecular functionproline-rich region binding
GO_0005509Molecular functioncalcium ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameITSN1
Protein nameIntersectin 1 isoform 8
ITSN1
Intersectin 1 short form A variant 2
Intersectin 1 isoform 9
Intersectin 1 isoform 7
ITSN1 protein
Intersectin 1 isoform A2
Intersectin short variant 12
Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17)
Intersectin 1
Intersectin 1 short form
Intersectin 1 isoform 6
Intersectin 1 short form variant 7
Intersectin 1 isoform 11
Intersectin 1 short form variant 4
Intersectin 1 isoform 5
SynonymsSH3D1A
ITSN
DescriptionFUNCTION: Adapter protein that provides a link between the endocytic membrane traffic and the actin assembly machinery . Acts as a guanine nucleotide exchange factor (GEF) for CDC42, and thereby stimulates actin nucleation mediated by WASL and the ARP2/3 complex . Plays a role in the assembly and maturation of clathrin-coated vesicles (By similarity). Recruits FCHSD2 to clathrin-coated pits . Involved in endocytosis of activated EGFR, and probably also other growth factor receptors (By similarity). Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2 . Promotes ubiquitination and subsequent degradation of EGFR, and thereby contributes to the down-regulation of EGFR-dependent signaling pathways. In chromaffin cells, required for normal exocytosis of catecholamines. Required for rapid replenishment of release-ready synaptic vesicles at presynaptic active zones (By similarity). Inhibits ARHGAP31 activity toward RAC1 . .; FUNCTION: [Isoform 1]: Plays a role in synaptic vesicle endocytosis in brain neurons. .

AccessionsENST00000399338.8 [Q15811-5]
A7XZY7
C9J1A4
C9JQZ7
Q6J333
ENST00000420666.1
A0A2X0TVY8
H0Y523
Q86VI9
H0Y7J7
ENST00000381283.7
Q15811
A8W608
ENST00000415023.1
ENST00000399349.5 [Q15811-3]
ENST00000381318.8 [Q15811-1]
Q6J334
Q7Z453
Q6PD56
Q7Z452
H0Y3G5
H7C3F1
ENST00000451686.5
ENST00000437126.5
ENST00000399355.6
ENST00000381285.8
ENST00000381284.7
Q6J1T1
Q6GMY7
H7C429
ENST00000399352.5 [Q15811-7]
ENST00000379960.9
Q6J1T2
ENST00000444491.5
Q0PW96
Q2LAE2
D6PAW2
H0Y6W3
ENST00000456489.1
ENST00000381291.8 [Q15811-2]
F8W7U0
Q14BD4
D6PAV9
D6PAW0
ENST00000399367.7 [Q15811-8]
A8CTZ0
ENST00000419241.1
ENST00000399353.5 [Q15811-10]
ENST00000440794.2
C9JXS9