Name | Number of supported studies | Average coverage | |
---|---|---|---|
macrophage | 20 studies | 43% ± 23% | |
astrocyte | 17 studies | 51% ± 22% | |
endothelial cell | 15 studies | 41% ± 20% | |
fibroblast | 14 studies | 33% ± 15% | |
glutamatergic neuron | 12 studies | 51% ± 23% | |
microglial cell | 12 studies | 32% ± 14% | |
GABAergic neuron | 11 studies | 50% ± 23% | |
oligodendrocyte precursor cell | 11 studies | 36% ± 15% | |
adipocyte | 10 studies | 72% ± 15% | |
amacrine cell | 8 studies | 31% ± 9% | |
retinal rod cell | 8 studies | 47% ± 26% | |
epithelial cell | 8 studies | 32% ± 13% | |
pericyte | 8 studies | 43% ± 17% | |
myeloid cell | 8 studies | 38% ± 17% | |
oligodendrocyte | 8 studies | 27% ± 10% | |
neuron | 7 studies | 43% ± 13% | |
retinal ganglion cell | 7 studies | 48% ± 15% | |
retinal cone cell | 7 studies | 43% ± 16% | |
interneuron | 6 studies | 66% ± 16% | |
retina horizontal cell | 6 studies | 27% ± 8% | |
Mueller cell | 6 studies | 39% ± 15% | |
endothelial cell of lymphatic vessel | 6 studies | 37% ± 15% | |
smooth muscle cell | 6 studies | 35% ± 6% | |
retinal bipolar neuron | 5 studies | 24% ± 5% | |
cardiac muscle cell | 5 studies | 25% ± 5% | |
dendritic cell | 5 studies | 24% ± 5% | |
type I pneumocyte | 5 studies | 37% ± 11% | |
hepatocyte | 4 studies | 57% ± 29% | |
granule cell | 4 studies | 38% ± 4% | |
ciliated cell | 4 studies | 20% ± 5% | |
OFF-bipolar cell | 4 studies | 34% ± 8% | |
ON-bipolar cell | 4 studies | 30% ± 9% | |
club cell | 4 studies | 19% ± 6% | |
monocyte | 4 studies | 30% ± 6% | |
GABAergic interneuron | 3 studies | 57% ± 4% | |
glial cell | 3 studies | 29% ± 11% | |
mesothelial cell | 3 studies | 34% ± 15% | |
mononuclear phagocyte | 3 studies | 32% ± 12% | |
GABAergic amacrine cell | 3 studies | 36% ± 5% | |
glycinergic amacrine cell | 3 studies | 33% ± 2% | |
rod bipolar cell | 3 studies | 28% ± 11% | |
connective tissue cell | 3 studies | 27% ± 7% | |
ependymal cell | 3 studies | 51% ± 11% | |
myofibroblast cell | 3 studies | 28% ± 7% | |
alveolar macrophage | 3 studies | 32% ± 5% | |
erythrocyte | 3 studies | 37% ± 11% | |
type II pneumocyte | 3 studies | 19% ± 4% | |
basal cell | 3 studies | 37% ± 20% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
brain | 100% | 5872.41 | 2640 / 2642 | 100% | 13.36 | 702 / 705 |
esophagus | 99% | 2631.92 | 1428 / 1445 | 98% | 5.81 | 180 / 183 |
breast | 100% | 6984.34 | 459 / 459 | 97% | 7.42 | 1085 / 1118 |
ovary | 100% | 4075.34 | 180 / 180 | 96% | 6.17 | 413 / 430 |
prostate | 100% | 3562.68 | 244 / 245 | 95% | 5.24 | 478 / 502 |
kidney | 100% | 2454.90 | 89 / 89 | 95% | 6.46 | 852 / 901 |
skin | 100% | 3856.37 | 1804 / 1809 | 94% | 6.03 | 444 / 472 |
lung | 99% | 2803.83 | 574 / 578 | 92% | 4.91 | 1065 / 1155 |
intestine | 100% | 3267.66 | 966 / 966 | 91% | 4.38 | 479 / 527 |
thymus | 100% | 2936.68 | 651 / 653 | 91% | 4.58 | 551 / 605 |
bladder | 100% | 3893.38 | 21 / 21 | 91% | 4.70 | 457 / 504 |
liver | 100% | 3249.70 | 226 / 226 | 87% | 4.35 | 354 / 406 |
stomach | 94% | 2065.85 | 337 / 359 | 93% | 5.15 | 265 / 286 |
uterus | 100% | 4983.60 | 170 / 170 | 86% | 5.12 | 395 / 459 |
adrenal gland | 100% | 3970.66 | 258 / 258 | 83% | 3.90 | 191 / 230 |
pancreas | 29% | 338.32 | 96 / 328 | 98% | 6.07 | 174 / 178 |
adipose | 100% | 9105.73 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 4925.03 | 1335 / 1335 | 0% | 0 | 0 / 0 |
spleen | 100% | 3124.60 | 241 / 241 | 0% | 0 | 0 / 0 |
muscle | 99% | 2167.40 | 796 / 803 | 0% | 0 | 0 / 0 |
heart | 91% | 2832.57 | 780 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 81% | 3.26 | 65 / 80 |
tonsil | 0% | 0 | 0 / 0 | 78% | 2.97 | 35 / 45 |
lymph node | 0% | 0 | 0 / 0 | 21% | 0.73 | 6 / 29 |
peripheral blood | 4% | 38.85 | 35 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0051056 | Biological process | regulation of small GTPase mediated signal transduction |
GO_0035556 | Biological process | intracellular signal transduction |
GO_0016197 | Biological process | endosomal transport |
GO_0006887 | Biological process | exocytosis |
GO_0150007 | Biological process | clathrin-dependent synaptic vesicle endocytosis |
GO_0015031 | Biological process | protein transport |
GO_0008104 | Biological process | protein localization |
GO_0005886 | Cellular component | plasma membrane |
GO_0055037 | Cellular component | recycling endosome |
GO_0097708 | Cellular component | intracellular vesicle |
GO_0043005 | Cellular component | neuron projection |
GO_0005635 | Cellular component | nuclear envelope |
GO_0042734 | Cellular component | presynaptic membrane |
GO_0005829 | Cellular component | cytosol |
GO_0005737 | Cellular component | cytoplasm |
GO_0005905 | Cellular component | clathrin-coated pit |
GO_0030027 | Cellular component | lamellipodium |
GO_0005085 | Molecular function | guanyl-nucleotide exchange factor activity |
GO_0060090 | Molecular function | molecular adaptor activity |
GO_0070064 | Molecular function | proline-rich region binding |
GO_0005509 | Molecular function | calcium ion binding |
GO_0005515 | Molecular function | protein binding |
Gene name | ITSN1 |
Protein name | Intersectin 1 isoform 8 ITSN1 Intersectin 1 short form A variant 2 Intersectin 1 isoform 9 Intersectin 1 isoform 7 ITSN1 protein Intersectin 1 isoform A2 Intersectin short variant 12 Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17) Intersectin 1 Intersectin 1 short form Intersectin 1 isoform 6 Intersectin 1 short form variant 7 Intersectin 1 isoform 11 Intersectin 1 short form variant 4 Intersectin 1 isoform 5 |
Synonyms | SH3D1A ITSN |
Description | FUNCTION: Adapter protein that provides a link between the endocytic membrane traffic and the actin assembly machinery . Acts as a guanine nucleotide exchange factor (GEF) for CDC42, and thereby stimulates actin nucleation mediated by WASL and the ARP2/3 complex . Plays a role in the assembly and maturation of clathrin-coated vesicles (By similarity). Recruits FCHSD2 to clathrin-coated pits . Involved in endocytosis of activated EGFR, and probably also other growth factor receptors (By similarity). Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2 . Promotes ubiquitination and subsequent degradation of EGFR, and thereby contributes to the down-regulation of EGFR-dependent signaling pathways. In chromaffin cells, required for normal exocytosis of catecholamines. Required for rapid replenishment of release-ready synaptic vesicles at presynaptic active zones (By similarity). Inhibits ARHGAP31 activity toward RAC1 . .; FUNCTION: [Isoform 1]: Plays a role in synaptic vesicle endocytosis in brain neurons. . |
Accessions | ENST00000399338.8 [Q15811-5] A7XZY7 C9J1A4 C9JQZ7 Q6J333 ENST00000420666.1 A0A2X0TVY8 H0Y523 Q86VI9 H0Y7J7 ENST00000381283.7 Q15811 A8W608 ENST00000415023.1 ENST00000399349.5 [Q15811-3] ENST00000381318.8 [Q15811-1] Q6J334 Q7Z453 Q6PD56 Q7Z452 H0Y3G5 H7C3F1 ENST00000451686.5 ENST00000437126.5 ENST00000399355.6 ENST00000381285.8 ENST00000381284.7 Q6J1T1 Q6GMY7 H7C429 ENST00000399352.5 [Q15811-7] ENST00000379960.9 Q6J1T2 ENST00000444491.5 Q0PW96 Q2LAE2 D6PAW2 H0Y6W3 ENST00000456489.1 ENST00000381291.8 [Q15811-2] F8W7U0 Q14BD4 D6PAV9 D6PAW0 ENST00000399367.7 [Q15811-8] A8CTZ0 ENST00000419241.1 ENST00000399353.5 [Q15811-10] ENST00000440794.2 C9JXS9 |