DENND10 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_2000641Biological processregulation of early endosome to late endosome transport
GO_0015031Biological processprotein transport
GO_0032509Biological processendosome transport via multivesicular body sorting pathway
GO_0005770Cellular componentlate endosome
GO_0005085Molecular functionguanyl-nucleotide exchange factor activity
GO_0005515Molecular functionprotein binding
GO_0031267Molecular functionsmall GTPase binding

IV. Literature review

[source]
Gene nameDENND10
Protein nameDENN domain containing 10
DENN domain-containing protein 10 (Protein FAM45A)
SynonymsFAM45A
DescriptionFUNCTION: Guanine nucleotide exchange factor (GEF) regulating homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion, possibly through activating Rab proteins such as RAB27A and RAB27B. Seems to promote the exchange of GDP to GTP, converting inactive GDP-bound RAB27A and RAB27B into their active GTP-bound form. .

AccessionsQ8TCE6
ENST00000361432.3 [Q8TCE6-1]
A0A3B3IRE4
ENST00000648560.1
ENST00000472379.2
A0A3B3IUD3