SH3BP5 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	41 studies	42% ± 16%	Explore
B cell	32 studies	29% ± 10%	Explore
macrophage	29 studies	30% ± 11%	Explore
natural killer cell	21 studies	25% ± 5%	Explore
fibroblast	20 studies	28% ± 12%	Explore
memory B cell	19 studies	27% ± 7%	Explore
naive B cell	16 studies	32% ± 7%	Explore
CD16-positive, CD56-dim natural killer cell, human	14 studies	26% ± 6%	Explore
classical monocyte	14 studies	27% ± 11%	Explore
endothelial cell of vascular tree	14 studies	36% ± 14%	Explore
dendritic cell	13 studies	27% ± 13%	Explore
vein endothelial cell	13 studies	46% ± 17%	Explore
monocyte	12 studies	24% ± 8%	Explore
capillary endothelial cell	12 studies	52% ± 16%	Explore
conventional dendritic cell	11 studies	35% ± 19%	Explore
endothelial cell of lymphatic vessel	10 studies	25% ± 5%	Explore
mature NK T cell	10 studies	22% ± 5%	Explore
endothelial cell of artery	9 studies	38% ± 16%	Explore
glutamatergic neuron	9 studies	35% ± 22%	Explore
oligodendrocyte	9 studies	25% ± 7%	Explore
alveolar macrophage	8 studies	25% ± 10%	Explore
CD16-negative, CD56-bright natural killer cell, human	8 studies	22% ± 5%	Explore
non-classical monocyte	8 studies	21% ± 4%	Explore
adipocyte	8 studies	30% ± 16%	Explore
gamma-delta T cell	8 studies	25% ± 12%	Explore
CD4-positive, alpha-beta T cell	7 studies	21% ± 7%	Explore
mononuclear phagocyte	6 studies	25% ± 6%	Explore
myeloid cell	6 studies	34% ± 4%	Explore
GABAergic neuron	6 studies	39% ± 16%	Explore
CD4-positive, alpha-beta memory T cell	6 studies	21% ± 4%	Explore
neutrophil	5 studies	22% ± 5%	Explore
CD8-positive, alpha-beta T cell	5 studies	23% ± 4%	Explore
connective tissue cell	5 studies	26% ± 9%	Explore
neuron	5 studies	26% ± 7%	Explore
mucosal invariant T cell	5 studies	19% ± 4%	Explore
mesothelial cell	5 studies	30% ± 11%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	24% ± 7%	Explore
interneuron	5 studies	35% ± 19%	Explore
T cell	4 studies	20% ± 4%	Explore
leukocyte	4 studies	17% ± 1%	Explore
endothelial cell of sinusoid	4 studies	36% ± 24%	Explore
glomerular endothelial cell	4 studies	60% ± 7%	Explore
regulatory T cell	4 studies	21% ± 5%	Explore
immature B cell	4 studies	37% ± 12%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	4 studies	21% ± 3%	Explore
smooth muscle cell	4 studies	31% ± 16%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	3 studies	17% ± 1%	Explore
effector memory CD8-positive, alpha-beta T cell	3 studies	23% ± 2%	Explore
plasmablast	3 studies	31% ± 8%	Explore
pericyte	3 studies	37% ± 13%	Explore
extravillous trophoblast	3 studies	66% ± 11%	Explore
precursor B cell	3 studies	24% ± 5%	Explore
innate lymphoid cell	3 studies	28% ± 4%	Explore
ciliated cell	3 studies	17% ± 0%	Explore
lymphocyte	3 studies	19% ± 2%	Explore
astrocyte	3 studies	24% ± 4%	Explore
adventitial cell	3 studies	20% ± 3%	Explore
granule cell	3 studies	28% ± 4%	Explore
CD8-positive, alpha-beta memory T cell	3 studies	21% ± 4%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	3 studies	21% ± 2%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	9 studies	23% ± 4%	Explore
brain	9 studies	31% ± 16%	Explore
lung	6 studies	21% ± 3%	Explore
placenta	4 studies	26% ± 9%	Explore
uterus	3 studies	27% ± 6%	Explore
adipose	3 studies	28% ± 5%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
breast	100%	1957.76	459 / 459	89%	6.81	997 / 1118
thymus	100%	1468.75	652 / 653	89%	7.58	536 / 605
ovary	100%	2900.72	180 / 180	88%	6.57	380 / 430
adrenal gland	100%	3868.87	258 / 258	80%	10.77	183 / 230
lung	100%	1841.85	577 / 578	79%	4.73	914 / 1155
skin	93%	603.16	1685 / 1809	81%	6.15	380 / 472
kidney	98%	1095.22	87 / 89	71%	6.45	639 / 901
brain	84%	708.72	2230 / 2642	82%	4.36	581 / 705
bladder	100%	862.14	21 / 21	62%	3.77	312 / 504
uterus	100%	2104.48	170 / 170	58%	4.28	267 / 459
prostate	89%	615.89	217 / 245	69%	2.83	348 / 502
esophagus	93%	526.99	1346 / 1445	62%	2.43	113 / 183
intestine	92%	659.10	885 / 966	53%	2.31	278 / 527
stomach	56%	334.53	201 / 359	62%	2.93	178 / 286
adipose	100%	2060.98	1204 / 1204	0%	0	0 / 0
blood vessel	100%	1203.18	1331 / 1335	0%	0	0 / 0
spleen	96%	624.85	231 / 241	0%	0	0 / 0
muscle	96%	1270.03	767 / 803	0%	0	0 / 0
pancreas	9%	28.33	31 / 328	83%	4.59	147 / 178
peripheral blood	88%	667.67	813 / 929	0%	0	0 / 0
lymph node	0%	0	0 / 0	83%	11.15	24 / 29
tonsil	0%	0	0 / 0	67%	5.16	30 / 45
heart	55%	277.78	473 / 861	0%	0	0 / 0
liver	18%	67.69	41 / 226	35%	1.33	144 / 406
eye	0%	0	0 / 0	34%	0.93	27 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0007165	Biological process	signal transduction
GO_0035556	Biological process	intracellular signal transduction
GO_0016604	Cellular component	nuclear body
GO_0005654	Cellular component	nucleoplasm
GO_0030659	Cellular component	cytoplasmic vesicle membrane
GO_0005737	Cellular component	cytoplasm
GO_0005739	Cellular component	mitochondrion
GO_0004860	Molecular function	protein kinase inhibitor activity
GO_0005085	Molecular function	guanyl-nucleotide exchange factor activity
GO_0017124	Molecular function	SH3 domain binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	SH3BP5
Protein name	SH3 domain binding protein 5 SH3 domain-binding protein 5 (SH3BP-5) (SH3 domain-binding protein that preferentially associates with BTK) SH3 domain-binding protein 5 (SH3BP-5)
Synonyms	SAB
Description	FUNCTION: Functions as a guanine nucleotide exchange factor (GEF) with specificity for RAB11A and RAB25 . Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death. . FUNCTION: Functions as guanine nucleotide exchange factor (GEF) for RAB11A. . FUNCTION: Functions as guanine nucleotide exchange factor (GEF) for RAB11A. . FUNCTION: Functions as guanine nucleotide exchange factor (GEF) for RAB11A. .
Accessions	F8WDU8 ENST00000450625.1 C9J140 ENST00000412806.1 O60239 C9JK30 ENST00000417936.5 C9JNW0 ENST00000408919.7 [O60239-2] ENST00000383791.8 [O60239-1] ENST00000426925.5 [O60239-2] ENST00000366391.6

SH3BP5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review