RHOF | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	33 studies	29% ± 9%	Explore
CD8-positive, alpha-beta T cell	29 studies	28% ± 10%	Explore
CD4-positive, alpha-beta T cell	24 studies	28% ± 7%	Explore
regulatory T cell	21 studies	32% ± 11%	Explore
T cell	20 studies	26% ± 8%	Explore
mature NK T cell	17 studies	30% ± 11%	Explore
memory B cell	15 studies	23% ± 4%	Explore
CD16-positive, CD56-dim natural killer cell, human	14 studies	34% ± 11%	Explore
B cell	13 studies	23% ± 6%	Explore
gamma-delta T cell	13 studies	34% ± 8%	Explore
naive B cell	12 studies	20% ± 5%	Explore
plasmacytoid dendritic cell	12 studies	31% ± 10%	Explore
CD16-negative, CD56-bright natural killer cell, human	11 studies	35% ± 9%	Explore
dendritic cell	11 studies	36% ± 14%	Explore
CD8-positive, alpha-beta memory T cell	10 studies	32% ± 12%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	10 studies	23% ± 5%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	10 studies	30% ± 8%	Explore
mucosal invariant T cell	10 studies	31% ± 7%	Explore
CD4-positive, alpha-beta memory T cell	9 studies	30% ± 13%	Explore
non-classical monocyte	7 studies	30% ± 14%	Explore
effector memory CD8-positive, alpha-beta T cell	7 studies	31% ± 9%	Explore
T follicular helper cell	7 studies	22% ± 3%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	33% ± 7%	Explore
conventional dendritic cell	6 studies	25% ± 9%	Explore
innate lymphoid cell	6 studies	27% ± 7%	Explore
exhausted T cell	5 studies	41% ± 11%	Explore
type I pneumocyte	4 studies	20% ± 3%	Explore
classical monocyte	4 studies	19% ± 4%	Explore
enterocyte	4 studies	17% ± 1%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	45% ± 5%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	39% ± 10%	Explore
T-helper 17 cell	4 studies	27% ± 4%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	29% ± 6%	Explore
platelet	4 studies	22% ± 6%	Explore
leukocyte	3 studies	19% ± 2%	Explore
hematopoietic precursor cell	3 studies	19% ± 1%	Explore
myeloid cell	3 studies	19% ± 1%	Explore
intraepithelial lymphocyte	3 studies	24% ± 6%	Explore
megakaryocyte	3 studies	35% ± 3%	Explore
group 3 innate lymphoid cell	3 studies	35% ± 11%	Explore
T-helper 1 cell	3 studies	35% ± 7%	Explore
double negative thymocyte	3 studies	32% ± 5%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	13 studies	22% ± 3%	Explore
lymph node	3 studies	21% ± 1%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
ovary	99%	124.85	178 / 180	85%	2.45	366 / 430
stomach	99%	171.58	354 / 359	56%	1.34	161 / 286
esophagus	99%	128.86	1429 / 1445	51%	1.20	94 / 183
intestine	99%	207.76	956 / 966	49%	1.27	258 / 527
pancreas	88%	58.93	290 / 328	42%	0.73	74 / 178
lung	99%	245.35	575 / 578	28%	0.65	325 / 1155
kidney	100%	191.44	89 / 89	17%	0.31	156 / 901
thymus	100%	307.22	653 / 653	17%	0.23	101 / 605
uterus	99%	184.94	169 / 170	17%	0.39	78 / 459
bladder	95%	168.29	20 / 21	19%	0.46	97 / 504
adrenal gland	100%	172.71	258 / 258	12%	0.28	28 / 230
prostate	100%	133.03	244 / 245	1%	0.01	4 / 502
spleen	100%	339.58	241 / 241	0%	0	0 / 0
peripheral blood	99%	389.37	918 / 929	0%	0	0 / 0
skin	93%	79.57	1678 / 1809	3%	0.04	12 / 472
blood vessel	95%	98.38	1271 / 1335	0%	0	0 / 0
breast	91%	88.44	417 / 459	2%	0.02	22 / 1118
heart	92%	108.53	789 / 861	0%	0	0 / 0
brain	89%	132.54	2361 / 2642	1%	0.02	9 / 705
adipose	84%	58.44	1008 / 1204	0%	0	0 / 0
muscle	81%	56.89	647 / 803	0%	0	0 / 0
lymph node	0%	0	0 / 0	79%	3.54	23 / 29
liver	53%	34.69	120 / 226	4%	0.07	17 / 406
tonsil	0%	0	0 / 0	2%	0.02	1 / 45
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0007165	Biological process	signal transduction
GO_0007015	Biological process	actin filament organization
GO_0032956	Biological process	regulation of actin cytoskeleton organization
GO_0051056	Biological process	regulation of small GTPase mediated signal transduction
GO_0016477	Biological process	cell migration
GO_0007264	Biological process	small GTPase-mediated signal transduction
GO_0030667	Cellular component	secretory granule membrane
GO_0070062	Cellular component	extracellular exosome
GO_0005856	Cellular component	cytoskeleton
GO_0005829	Cellular component	cytosol
GO_0005886	Cellular component	plasma membrane
GO_0005525	Molecular function	GTP binding
GO_0005085	Molecular function	guanyl-nucleotide exchange factor activity
GO_0019901	Molecular function	protein kinase binding
GO_0003924	Molecular function	GTPase activity

IV. Literature review

[source]

Gene name	RHOF
Protein name	Rho-related GTP-binding protein RhoF (Rho family GTPase Rif) (Rho in filopodia) Ras homolog family member F, filopodia associated
Synonyms	ARHF RIF
Description	FUNCTION: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Causes the formation of thin, actin-rich surface projections called filopodia. Functions cooperatively with CDC42 and Rac to generate additional structures, increasing the diversity of actin-based morphology.
Accessions	ENST00000537171.5 [Q9HBH0-2] ENST00000541657.5 F5GXB1 Q9HBH0 V9GY67 ENST00000535560.1 V9GYQ1 ENST00000267205.7 [Q9HBH0-1] V9GYB3 ENST00000537265.5 ENST00000546227.5

RHOF report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review