DOCK2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	31 studies	38% ± 23%	Explore
B cell	22 studies	28% ± 14%	Explore
classical monocyte	22 studies	28% ± 12%	Explore
non-classical monocyte	21 studies	35% ± 14%	Explore
natural killer cell	19 studies	25% ± 11%	Explore
monocyte	16 studies	39% ± 22%	Explore
CD8-positive, alpha-beta T cell	14 studies	25% ± 10%	Explore
dendritic cell	13 studies	46% ± 22%	Explore
mast cell	13 studies	38% ± 18%	Explore
microglial cell	13 studies	61% ± 22%	Explore
T cell	12 studies	30% ± 14%	Explore
CD16-positive, CD56-dim natural killer cell, human	12 studies	22% ± 8%	Explore
memory B cell	12 studies	18% ± 2%	Explore
plasmacytoid dendritic cell	12 studies	27% ± 8%	Explore
CD16-negative, CD56-bright natural killer cell, human	11 studies	24% ± 9%	Explore
conventional dendritic cell	11 studies	26% ± 14%	Explore
myeloid cell	11 studies	46% ± 21%	Explore
CD4-positive, alpha-beta T cell	10 studies	27% ± 12%	Explore
naive B cell	10 studies	20% ± 4%	Explore
regulatory T cell	10 studies	27% ± 14%	Explore
effector memory CD8-positive, alpha-beta T cell	8 studies	27% ± 11%	Explore
gamma-delta T cell	8 studies	22% ± 10%	Explore
mature NK T cell	7 studies	22% ± 11%	Explore
mucosal invariant T cell	7 studies	24% ± 11%	Explore
leukocyte	7 studies	46% ± 22%	Explore
CD8-positive, alpha-beta memory T cell	6 studies	23% ± 6%	Explore
mononuclear phagocyte	5 studies	35% ± 14%	Explore
lymphocyte	5 studies	47% ± 24%	Explore
alveolar macrophage	5 studies	46% ± 26%	Explore
plasma cell	4 studies	42% ± 7%	Explore
glutamatergic neuron	4 studies	28% ± 10%	Explore
oligodendrocyte	4 studies	26% ± 14%	Explore
plasmablast	3 studies	25% ± 5%	Explore
exhausted T cell	3 studies	24% ± 10%	Explore
hematopoietic precursor cell	3 studies	45% ± 20%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	3 studies	32% ± 13%	Explore
tissue-resident macrophage	3 studies	32% ± 20%	Explore
neutrophil	3 studies	43% ± 8%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	3 studies	30% ± 17%	Explore
CD4-positive, alpha-beta memory T cell	3 studies	18% ± 3%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	11 studies	23% ± 7%	Explore
lung	4 studies	24% ± 5%	Explore
brain	4 studies	26% ± 8%	Explore
bone marrow	3 studies	21% ± 6%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	100%	4308.47	578 / 578	84%	7.52	968 / 1155
breast	88%	887.44	402 / 459	86%	6.82	961 / 1118
stomach	92%	1106.89	331 / 359	67%	4.73	191 / 286
intestine	87%	1749.87	836 / 966	56%	3.52	296 / 527
bladder	81%	872.52	17 / 21	50%	3.46	254 / 504
esophagus	63%	475.39	917 / 1445	62%	3.25	113 / 183
thymus	64%	663.78	421 / 653	58%	6.89	349 / 605
skin	48%	295.15	862 / 1809	74%	7.81	349 / 472
kidney	43%	499.69	38 / 89	77%	7.31	693 / 901
adrenal gland	86%	871.12	222 / 258	30%	1.08	68 / 230
prostate	71%	569.64	174 / 245	44%	1.86	221 / 502
uterus	56%	353.36	96 / 170	54%	2.75	246 / 459
brain	24%	203.94	647 / 2642	84%	6.40	595 / 705
lymph node	0%	0	0 / 0	100%	57.05	29 / 29
peripheral blood	100%	15135.08	929 / 929	0%	0	0 / 0
spleen	100%	11003.86	241 / 241	0%	0	0 / 0
adipose	98%	1750.20	1182 / 1204	0%	0	0 / 0
pancreas	16%	116.05	53 / 328	81%	6.74	144 / 178
tonsil	0%	0	0 / 0	80%	7.87	36 / 45
ovary	30%	192.22	54 / 180	45%	1.92	193 / 430
liver	42%	272.08	95 / 226	29%	1.44	119 / 406
blood vessel	67%	765.42	892 / 1335	0%	0	0 / 0
heart	33%	236.82	282 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	19%	0.84	15 / 80
muscle	3%	14.50	23 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0044351	Biological process	macropinocytosis
GO_0002277	Biological process	myeloid dendritic cell activation involved in immune response
GO_0050766	Biological process	positive regulation of phagocytosis
GO_0001771	Biological process	immunological synapse formation
GO_0051056	Biological process	regulation of small GTPase mediated signal transduction
GO_0006935	Biological process	chemotaxis
GO_0030036	Biological process	actin cytoskeleton organization
GO_0001768	Biological process	establishment of T cell polarity
GO_0007264	Biological process	small GTPase-mediated signal transduction
GO_0001766	Biological process	membrane raft polarization
GO_0045060	Biological process	negative thymic T cell selection
GO_0045059	Biological process	positive thymic T cell selection
GO_0007520	Biological process	myoblast fusion
GO_0046633	Biological process	alpha-beta T cell proliferation
GO_0016477	Biological process	cell migration
GO_0005856	Cellular component	cytoskeleton
GO_0005576	Cellular component	extracellular region
GO_0005886	Cellular component	plasma membrane
GO_0035580	Cellular component	specific granule lumen
GO_0016020	Cellular component	membrane
GO_0070062	Cellular component	extracellular exosome
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0005085	Molecular function	guanyl-nucleotide exchange factor activity
GO_0042608	Molecular function	T cell receptor binding
GO_0031267	Molecular function	small GTPase binding
GO_0005096	Molecular function	GTPase activator activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	DOCK2
Protein name	Dedicator of cytokinesis protein 2 DOCK2 protein Dedicator of cytokinesis 2 DOCK2
Synonyms	KIAA0209
Description	FUNCTION: Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. Activates RAC1 and RAC2, but not CDC42, by functioning as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. May also participate in IL2 transcriptional activation via the activation of RAC2. .
Accessions	E5RFJ0 A0A8Q3WL64 ENST00000519628.2 ENST00000519734.5 ENST00000522138.2 ENST00000520908.7 [Q92608-1] Q92608 A0A3B3IRS9 H0YB76 A0A2X0SFD3 A0A3B3ISB1 Q5XG91 ENST00000523684.5 ENST00000524185.5

DOCK2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review