VAV3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0001525Biological processangiogenesis
GO_0030032Biological processlamellipodium assembly
GO_0051056Biological processregulation of small GTPase mediated signal transduction
GO_0006974Biological processDNA damage response
GO_0030593Biological processneutrophil chemotaxis
GO_0050853Biological processB cell receptor signaling pathway
GO_0038095Biological processFc-epsilon receptor signaling pathway
GO_0045785Biological processpositive regulation of cell adhesion
GO_0030168Biological processplatelet activation
GO_0007229Biological processintegrin-mediated signaling pathway
GO_0043087Biological processregulation of GTPase activity
GO_0030890Biological processpositive regulation of B cell proliferation
GO_0007264Biological processsmall GTPase-mediated signal transduction
GO_0051897Biological processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0008361Biological processregulation of cell size
GO_0006906Biological processvesicle fusion
GO_0009410Biological processresponse to xenobiotic stimulus
GO_0016477Biological processcell migration
GO_0038096Biological processFc-gamma receptor signaling pathway involved in phagocytosis
GO_0001772Cellular componentimmunological synapse
GO_0005886Cellular componentplasma membrane
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005085Molecular functionguanyl-nucleotide exchange factor activity
GO_0005154Molecular functionepidermal growth factor receptor binding
GO_0005096Molecular functionGTPase activator activity
GO_0046872Molecular functionmetal ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameVAV3
Protein nameVav guanine nucleotide exchange factor 3
VAV3
Guanine nucleotide exchange factor VAV3 (VAV-3)
Synonyms
DescriptionFUNCTION: Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity). May be important for integrin-mediated signaling, at least in some cell types. In osteoclasts, along with SYK tyrosine kinase, required for signaling through integrin alpha-v/beta-1 (ITAGV-ITGB1), a crucial event for osteoclast proper cytoskeleton organization and function. This signaling pathway involves RAC1, but not RHO, activation. Necessary for proper wound healing. In the course of wound healing, required for the phagocytotic cup formation preceding macrophage phagocytosis of apoptotic neutrophils. Responsible for integrin beta-2 (ITGB2)-mediated macrophage adhesion and, to a lesser extent, contributes to beta-3 (ITGB3)-mediated adhesion. Does not affect integrin beta-1 (ITGB1)-mediated adhesion (By similarity). .

AccessionsENST00000370056.9 [Q9UKW4-1]
E9PMJ5
H0YCG7
Q9UKW4
ENST00000415432.6 [Q9UKW4-3]
H0YDG2
A0A2X0U2Q1
ENST00000529809.5
ENST00000527011.5 [Q9UKW4-4]
ENST00000490388.2
ENST00000529413.5
ENST00000525231.5