RIN1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of RIN1 at tissue level.

III. Associated gene sets

GO_0007165Biological processsignal transduction
GO_0006897Biological processendocytosis
GO_0005856Cellular componentcytoskeleton
GO_0005829Cellular componentcytosol
GO_0005886Cellular componentplasma membrane
GO_0005737Cellular componentcytoplasm
GO_0030139Cellular componentendocytic vesicle
GO_0005085Molecular functionguanyl-nucleotide exchange factor activity
GO_0005515Molecular functionprotein binding
GO_0031267Molecular functionsmall GTPase binding
GO_0005096Molecular functionGTPase activator activity

IV. Literature review

[source]
Gene nameRIN1
Protein nameRas and Rab interactor 1 isoform 2
Ras and Rab interactor 1 (Ras inhibitor JC99) (Ras interaction/interference protein 1)
Ras and Rab interactor 1 isoform 3
Ras and Rab interactor 1
SynonymshCG_20306
DescriptionFUNCTION: Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis. .

AccessionsENST00000530745.3
H0YCG8
ENST00000534824.5
ENST00000530056.1
E9PNR2
A0A0S2Z4T3
ENST00000627248.1
A0A0S2Z4T5
ENST00000311320.9 [Q13671-1]
A0A0S2Z4U0
Q13671
E9PMB8