KALRN report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0048013Biological processephrin receptor signaling pathway
GO_0007165Biological processsignal transduction
GO_0051056Biological processregulation of small GTPase mediated signal transduction
GO_0016192Biological processvesicle-mediated transport
GO_0035556Biological processintracellular signal transduction
GO_0006468Biological processprotein phosphorylation
GO_0007399Biological processnervous system development
GO_0007411Biological processaxon guidance
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0019898Cellular componentextrinsic component of membrane
GO_0015629Cellular componentactin cytoskeleton
GO_0005829Cellular componentcytosol
GO_0014069Cellular componentpostsynaptic density
GO_0005737Cellular componentcytoplasm
GO_0005085Molecular functionguanyl-nucleotide exchange factor activity
GO_0106310Molecular functionprotein serine kinase activity
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0046872Molecular functionmetal ion binding
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameKALRN
Protein nameKalirin RhoGEF kinase
HCG2022551, isoform CRA_f (Kalirin RhoGEF kinase)
non-specific serine/threonine protein kinase (EC 2.7.11.1)
Kalirin
Kalirin (EC 2.7.11.1) (Huntingtin-associated protein-interacting protein) (Protein Duo) (Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain)
HCG2022551, isoform CRA_j (Kalirin RhoGEF kinase)
SynonymsDUET
HAPIP
DUO
TRAD
hCG_2022551
DescriptionFUNCTION: Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity. .

AccessionsO60229
ENST00000684360.1
A0A804HIY9
ENST00000360013.7 [O60229-1]
A0A804HI91
A0A804HKJ7
A0A804HII1
ENST00000354186.8
ENST00000684382.1
ENST00000683428.1
A0A0D9SGH1
C9J1B4
ENST00000683356.1
ENST00000682540.1
H7BXZ5
A0A804HJ49
A0A1S5UZ29
A0A804HLF3
H7C1X7
ENST00000291478.9 [O60229-4]
ENST00000682625.1
A0A804HIN3
ENST00000682363.1
ENST00000682861.1
ENST00000682277.1
A0A804HKU9
A0A804HJ74
A0A804HI42
ENST00000439170.2
ENST00000682890.1
ENST00000683571.1
A0A804HJC5
C9IZQ6
A0A804HIP9
ENST00000684374.1
ENST00000682575.1
A0A804HJZ3
ENST00000682506.1
ENST00000682636.1
ENST00000522553.6
A0A804HLC8
ENST00000684276.1
A0A804HLI0
ENST00000682695.1
ENST00000682290.1
A0A804HIK8
A0A804HI83
ENST00000683280.1
A0A804HJX0
ENST00000682674.1
ENST00000454902.1
ENST00000240874.7 [O60229-2]
ENST00000460856.5
A0A804HHT5
A0A804HKT9
ENST00000684186.1
ENST00000683146.1
ENST00000483658.2