RIC1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0003330Biological processregulation of extracellular matrix constituent secretion
GO_0042147Biological processretrograde transport, endosome to Golgi
GO_0042177Biological processnegative regulation of protein catabolic process
GO_1904888Biological processcranial skeletal system development
GO_0006886Biological processintracellular protein transport
GO_0043547Biological processpositive regulation of GTPase activity
GO_0032588Cellular componenttrans-Golgi network membrane
GO_0000139Cellular componentGolgi membrane
GO_0032991Cellular componentprotein-containing complex
GO_0005829Cellular componentcytosol
GO_0034066Cellular componentRic1-Rgp1 guanyl-nucleotide exchange factor complex
GO_0016020Cellular componentmembrane
GO_0005085Molecular functionguanyl-nucleotide exchange factor activity
GO_0005515Molecular functionprotein binding
GO_0031267Molecular functionsmall GTPase binding

IV. Literature review

[source]
Gene nameRIC1
Protein nameProtein RIC1 homolog
Guanine nucleotide exchange factor subunit RIC1 (Connexin-43-interacting protein of 150 kDa) (Protein RIC1 homolog) (RAB6A-GEF complex partner protein 1)
RIC1 homolog, RAB6A GEF complex partner 1
SynonymsKIAA1432
CIP150
DescriptionFUNCTION: The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP, and may thereby be required for efficient fusion of endosome-derived vesicles with the Golgi compartment . The RIC1-RGP1 complex participates in the recycling of mannose-6-phosphate receptors . Required for phosphorylation and localization of GJA1 . Is a regulator of procollagen transport and secretion, and is required for correct cartilage morphogenesis and development of the craniofacial skeleton . .

AccessionsQ4ADV7
ENST00000251879.10 [Q4ADV7-2]
ENST00000418622.7 [Q4ADV7-3]
ENST00000414202.7 [Q4ADV7-1]
ENST00000545641.5
ENST00000545243.1
H0YFN7
H0YGC4
ENST00000490816.1
H0YFD4