FGD5 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of FGD5 at tissue level.

III. Associated gene sets

GO_0051056Biological processregulation of small GTPase mediated signal transduction
GO_0007010Biological processcytoskeleton organization
GO_0030036Biological processactin cytoskeleton organization
GO_0043087Biological processregulation of GTPase activity
GO_0046847Biological processfilopodium assembly
GO_0008360Biological processregulation of cell shape
GO_0001726Cellular componentruffle
GO_0032587Cellular componentruffle membrane
GO_0005856Cellular componentcytoskeleton
GO_0005886Cellular componentplasma membrane
GO_0005769Cellular componentearly endosome
GO_0005794Cellular componentGolgi apparatus
GO_0005783Cellular componentendoplasmic reticulum
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0030027Cellular componentlamellipodium
GO_0005085Molecular functionguanyl-nucleotide exchange factor activity
GO_0031267Molecular functionsmall GTPase binding
GO_0046872Molecular functionmetal ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameFGD5
Protein nameFGD5 protein (FYVE, RhoGEF and PH domain containing 5)
FGD5
Alternative protein FGD5
FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23)
FYVE, RhoGEF and PH domain containing 5
SynonymsZFYVE23
DescriptionFUNCTION: Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape. .

AccessionsH7C0G2
B7ZM68
Q6ZNL6
ENST00000285046.10 [Q6ZNL6-1]
A0A1W2PRG7
ENST00000457774.1
A0A2X0SFF2
ENST00000543601.5
L0R6G7
ENST00000640506.1
A3KMQ0