EIF2B3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0014003Biological processoligodendrocyte development
GO_0002183Biological processcytoplasmic translational initiation
GO_0009408Biological processresponse to heat
GO_0006413Biological processtranslational initiation
GO_0043434Biological processresponse to peptide hormone
GO_0009749Biological processresponse to glucose
GO_0050852Biological processT cell receptor signaling pathway
GO_0005829Cellular componentcytosol
GO_0005851Cellular componenteukaryotic translation initiation factor 2B complex
GO_0032045Cellular componentguanyl-nucleotide exchange factor complex
GO_0005737Cellular componentcytoplasm
GO_0003743Molecular functiontranslation initiation factor activity
GO_0008135Molecular functiontranslation factor activity, RNA binding
GO_0005085Molecular functionguanyl-nucleotide exchange factor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameEIF2B3
Protein name(human) hypothetical protein (Eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa, isoform CRA_e) (eIF2B3 protein)
Eukaryotic translation initiation factor 2B subunit gamma
Translation initiation factor eIF2B subunit gamma (eIF2B GDP-GTP exchange factor subunit gamma)
SynonymshCG_18606
DescriptionFUNCTION: Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on the eukaryotic initiation factor 2 (eIF2) complex gamma subunit . Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed . .

AccessionsQ9NR50
ENST00000439363.5
ENST00000480675.5
H0Y580
A0A0D9SEN0
Q9HA31
ENST00000360403.7 [Q9NR50-1]
ENST00000620860.4 [Q9NR50-3]
ENST00000372183.7 [Q9NR50-2]