Name | Number of supported studies | Average coverage | |
---|---|---|---|
fibroblast | 9 studies | 20% ± 3% | |
adipocyte | 9 studies | 40% ± 10% | |
endothelial cell | 7 studies | 24% ± 8% | |
macrophage | 6 studies | 20% ± 7% | |
GABAergic neuron | 6 studies | 38% ± 20% | |
astrocyte | 6 studies | 30% ± 11% | |
oligodendrocyte | 6 studies | 25% ± 8% | |
glutamatergic neuron | 5 studies | 49% ± 21% | |
microglial cell | 5 studies | 25% ± 6% | |
epithelial cell | 5 studies | 23% ± 5% | |
cardiac muscle cell | 4 studies | 21% ± 3% | |
type II pneumocyte | 4 studies | 18% ± 2% | |
oligodendrocyte precursor cell | 4 studies | 30% ± 8% | |
interneuron | 4 studies | 39% ± 18% | |
dendritic cell | 3 studies | 21% ± 2% | |
pericyte | 3 studies | 21% ± 5% | |
transit amplifying cell | 3 studies | 25% ± 11% | |
neuron | 3 studies | 31% ± 9% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
breast | 100% | 1713.01 | 459 / 459 | 100% | 30.05 | 1118 / 1118 |
esophagus | 100% | 1337.70 | 1445 / 1445 | 100% | 15.15 | 183 / 183 |
ovary | 100% | 1319.66 | 180 / 180 | 100% | 17.19 | 430 / 430 |
prostate | 100% | 1202.03 | 245 / 245 | 100% | 26.20 | 502 / 502 |
stomach | 100% | 864.25 | 359 / 359 | 100% | 17.93 | 286 / 286 |
uterus | 100% | 1385.84 | 170 / 170 | 100% | 30.10 | 459 / 459 |
skin | 100% | 1493.21 | 1808 / 1809 | 100% | 27.70 | 472 / 472 |
pancreas | 100% | 707.33 | 327 / 328 | 100% | 17.46 | 178 / 178 |
thymus | 100% | 1036.15 | 652 / 653 | 100% | 22.40 | 604 / 605 |
intestine | 100% | 1094.90 | 964 / 966 | 100% | 20.19 | 526 / 527 |
lung | 100% | 1068.41 | 576 / 578 | 100% | 21.48 | 1154 / 1155 |
liver | 100% | 979.25 | 225 / 226 | 100% | 18.67 | 406 / 406 |
bladder | 100% | 1368.52 | 21 / 21 | 99% | 24.29 | 501 / 504 |
kidney | 100% | 909.46 | 89 / 89 | 99% | 15.00 | 894 / 901 |
brain | 98% | 1022.24 | 2594 / 2642 | 100% | 23.43 | 705 / 705 |
adrenal gland | 100% | 1969.02 | 258 / 258 | 97% | 16.36 | 224 / 230 |
adipose | 100% | 1701.08 | 1204 / 1204 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 30.24 | 29 / 29 |
muscle | 100% | 3197.48 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 1110.62 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 26.09 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 12.27 | 1 / 1 |
blood vessel | 100% | 1441.24 | 1334 / 1335 | 0% | 0 | 0 / 0 |
heart | 98% | 1706.55 | 841 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 98% | 15.28 | 78 / 80 |
peripheral blood | 63% | 568.19 | 589 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0014003 | Biological process | oligodendrocyte development |
GO_0002183 | Biological process | cytoplasmic translational initiation |
GO_0009408 | Biological process | response to heat |
GO_0006413 | Biological process | translational initiation |
GO_0043434 | Biological process | response to peptide hormone |
GO_0009749 | Biological process | response to glucose |
GO_0050852 | Biological process | T cell receptor signaling pathway |
GO_0005829 | Cellular component | cytosol |
GO_0005851 | Cellular component | eukaryotic translation initiation factor 2B complex |
GO_0032045 | Cellular component | guanyl-nucleotide exchange factor complex |
GO_0005737 | Cellular component | cytoplasm |
GO_0003743 | Molecular function | translation initiation factor activity |
GO_0008135 | Molecular function | translation factor activity, RNA binding |
GO_0005085 | Molecular function | guanyl-nucleotide exchange factor activity |
GO_0005515 | Molecular function | protein binding |
Gene name | EIF2B3 |
Protein name | (human) hypothetical protein (Eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa, isoform CRA_e) (eIF2B3 protein) Eukaryotic translation initiation factor 2B subunit gamma Translation initiation factor eIF2B subunit gamma (eIF2B GDP-GTP exchange factor subunit gamma) |
Synonyms | hCG_18606 |
Description | FUNCTION: Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on the eukaryotic initiation factor 2 (eIF2) complex gamma subunit . Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed . . |
Accessions | Q9NR50 ENST00000439363.5 ENST00000480675.5 H0Y580 A0A0D9SEN0 Q9HA31 ENST00000360403.7 [Q9NR50-1] ENST00000620860.4 [Q9NR50-3] ENST00000372183.7 [Q9NR50-2] |