PLEKHG5 | OmnibusX

Name	Number of supported studies	Average coverage
macrophage	5 studies	22% ± 7%	Explore
endothelial cell	4 studies	25% ± 7%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of PLEKHG5 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
uterus	92%	2349.29	157 / 170	97%	19.89	446 / 459
esophagus	87%	3073.63	1260 / 1445	100%	25.09	183 / 183
breast	95%	3221.19	437 / 459	88%	8.13	979 / 1118
thymus	85%	1867.08	555 / 653	96%	9.59	581 / 605
adrenal gland	95%	2806.71	246 / 258	84%	23.08	194 / 230
ovary	79%	1709.34	143 / 180	98%	14.21	423 / 430
intestine	78%	1683.57	751 / 966	98%	13.77	515 / 527
lung	72%	1450.11	415 / 578	93%	13.38	1079 / 1155
brain	75%	7592.28	1974 / 2642	90%	8.45	635 / 705
bladder	67%	1242.14	14 / 21	98%	16.37	492 / 504
prostate	94%	2596.05	230 / 245	69%	3.83	347 / 502
kidney	63%	1207.72	56 / 89	75%	6.21	675 / 901
stomach	27%	485.08	97 / 359	95%	13.66	272 / 286
skin	75%	12562.95	1348 / 1809	44%	3.74	207 / 472
spleen	100%	13489.89	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	7.34	1 / 1
tonsil	0%	0	0 / 0	98%	20.03	44 / 45
pancreas	4%	59.43	12 / 328	93%	10.08	166 / 178
adipose	91%	3367.10	1100 / 1204	0%	0	0 / 0
heart	80%	1832.34	686 / 861	0%	0	0 / 0
blood vessel	49%	1147.73	658 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	39%	2.05	31 / 80
liver	1%	20.52	3 / 226	22%	1.20	88 / 406
lymph node	0%	0	0 / 0	3%	0.11	1 / 29
muscle	3%	40.39	21 / 803	0%	0	0 / 0
peripheral blood	0%	1.94	1 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0007266	Biological process	Rho protein signal transduction
GO_0051056	Biological process	regulation of small GTPase mediated signal transduction
GO_0043542	Biological process	endothelial cell migration
GO_0043123	Biological process	positive regulation of canonical NF-kappaB signal transduction
GO_0035767	Biological process	endothelial cell chemotaxis
GO_0005911	Cellular component	cell-cell junction
GO_0030424	Cellular component	axon
GO_0005829	Cellular component	cytosol
GO_0030027	Cellular component	lamellipodium
GO_0005886	Cellular component	plasma membrane
GO_0030139	Cellular component	endocytic vesicle
GO_0048471	Cellular component	perinuclear region of cytoplasm
GO_0005737	Cellular component	cytoplasm
GO_0005085	Molecular function	guanyl-nucleotide exchange factor activity

Gene name	PLEKHG5
Protein name	Pleckstrin homology and RhoGEF domain containing G5 Pleckstrin homology domain-containing family G member 5 Pleckstrin homology domain-containing family G member 5 (PH domain-containing family G member 5) (Guanine nucleotide exchange factor 720) (GEF720)
Synonyms	KIAA0720
Description	FUNCTION: Functions as a guanine exchange factor (GEF) for RAB26 and thus regulates autophagy of synaptic vesicles in axon terminal of motoneurons (By similarity). Involved in the control of neuronal cell differentiation . Plays a role in angiogenesis through regulation of endothelial cells chemotaxis. Affects also the migration, adhesion, and matrix/bone degradation in macrophages and osteoclasts . .
Accessions	ENST00000675123.1 ENST00000377740.5 [O94827-5] A0A6Q8PG76 ENST00000377740 A0A6Q8PHS0 ENST00000675976.1 ENST00000673471.2 ENST00000676255.1 O94827 ENST00000675548.1 ENST00000400913.6 [O94827-5] A0A6Q8PF22 ENST00000400915.8 [O94827-3] ENST00000377728.8 [O94827-5] A0A6Q8PHR5 A0A5F9ZHW8 ENST00000674790.1 ENST00000675093.1 Q5SY18 ENST00000537245.6 [O94827-3] ENST00000535355.6 A0A6Q8PHD3 ENST00000377732.5 [O94827-3] A0A804EMX3 A0A6Q8PGZ5 ENST00000377725.5 [O94827-4] A0A7I2PMD6 ENST00000340850.10 [O94827-5] ENST00000675694.1 [O94827-5] ENST00000377748.6 A0A6Q8PHJ1 ENST00000676287.1

PLEKHG5 report