Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 20 studies | 31% ± 12% | |
macrophage | 17 studies | 39% ± 19% | |
astrocyte | 14 studies | 42% ± 19% | |
microglial cell | 10 studies | 64% ± 20% | |
glutamatergic neuron | 9 studies | 46% ± 15% | |
myeloid cell | 9 studies | 42% ± 18% | |
epithelial cell | 8 studies | 29% ± 16% | |
dendritic cell | 8 studies | 37% ± 12% | |
GABAergic neuron | 7 studies | 41% ± 13% | |
smooth muscle cell | 7 studies | 21% ± 3% | |
fibroblast | 7 studies | 22% ± 4% | |
neuron | 6 studies | 36% ± 12% | |
oligodendrocyte precursor cell | 6 studies | 25% ± 13% | |
ciliated cell | 6 studies | 33% ± 8% | |
T cell | 6 studies | 19% ± 2% | |
monocyte | 6 studies | 44% ± 16% | |
interneuron | 5 studies | 46% ± 12% | |
retinal ganglion cell | 5 studies | 36% ± 21% | |
cardiac muscle cell | 5 studies | 27% ± 6% | |
endothelial cell of artery | 5 studies | 29% ± 16% | |
basal cell | 5 studies | 31% ± 18% | |
type II pneumocyte | 5 studies | 22% ± 4% | |
classical monocyte | 4 studies | 23% ± 6% | |
retinal pigment epithelial cell | 4 studies | 62% ± 18% | |
pericyte | 4 studies | 22% ± 7% | |
alveolar macrophage | 4 studies | 58% ± 26% | |
non-classical monocyte | 3 studies | 31% ± 5% | |
capillary endothelial cell | 3 studies | 19% ± 6% | |
retinal bipolar neuron | 3 studies | 18% ± 3% | |
mononuclear phagocyte | 3 studies | 31% ± 11% | |
vein endothelial cell | 3 studies | 27% ± 15% | |
Mueller cell | 3 studies | 23% ± 2% | |
OFF-bipolar cell | 3 studies | 20% ± 3% | |
endothelial cell of lymphatic vessel | 3 studies | 23% ± 6% | |
endothelial cell of vascular tree | 3 studies | 39% ± 15% | |
B cell | 3 studies | 23% ± 5% | |
club cell | 3 studies | 19% ± 1% | |
natural killer cell | 3 studies | 19% ± 3% | |
lymphocyte | 3 studies | 35% ± 9% | |
leukocyte | 3 studies | 56% ± 17% | |
transit amplifying cell | 3 studies | 36% ± 25% | |
mast cell | 3 studies | 26% ± 12% | |
mucus secreting cell | 3 studies | 26% ± 4% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 11596.94 | 1444 / 1445 | 100% | 40.54 | 183 / 183 |
brain | 100% | 21254.86 | 2640 / 2642 | 100% | 85.23 | 705 / 705 |
intestine | 100% | 14109.86 | 966 / 966 | 100% | 43.85 | 526 / 527 |
skin | 100% | 8293.55 | 1807 / 1809 | 100% | 71.32 | 471 / 472 |
prostate | 100% | 8416.32 | 245 / 245 | 99% | 23.85 | 497 / 502 |
stomach | 99% | 6239.81 | 357 / 359 | 99% | 41.43 | 284 / 286 |
breast | 100% | 7594.98 | 459 / 459 | 97% | 25.21 | 1089 / 1118 |
lung | 100% | 11334.30 | 578 / 578 | 97% | 28.40 | 1125 / 1155 |
bladder | 100% | 8061.33 | 21 / 21 | 95% | 26.79 | 479 / 504 |
thymus | 96% | 4082.88 | 625 / 653 | 99% | 30.41 | 598 / 605 |
uterus | 100% | 8928.14 | 170 / 170 | 93% | 23.69 | 427 / 459 |
adrenal gland | 100% | 7855.94 | 258 / 258 | 90% | 40.55 | 206 / 230 |
kidney | 92% | 4603.62 | 82 / 89 | 95% | 26.72 | 852 / 901 |
ovary | 100% | 5399.62 | 180 / 180 | 55% | 8.13 | 235 / 430 |
pancreas | 43% | 1323.35 | 141 / 328 | 99% | 34.33 | 176 / 178 |
blood vessel | 100% | 14152.13 | 1335 / 1335 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 100% | 164.27 | 80 / 80 |
lymph node | 0% | 0 | 0 / 0 | 100% | 31.57 | 29 / 29 |
spleen | 100% | 9316.50 | 241 / 241 | 0% | 0 | 0 / 0 |
adipose | 100% | 7772.32 | 1202 / 1204 | 0% | 0 | 0 / 0 |
heart | 98% | 9154.93 | 848 / 861 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 98% | 31.62 | 44 / 45 |
peripheral blood | 91% | 6294.37 | 849 / 929 | 0% | 0 | 0 / 0 |
muscle | 28% | 797.19 | 226 / 803 | 0% | 0 | 0 / 0 |
liver | 1% | 41.72 | 2 / 226 | 19% | 4.31 | 77 / 406 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0051056 | Biological process | regulation of small GTPase mediated signal transduction |
GO_0050804 | Biological process | modulation of chemical synaptic transmission |
GO_0007264 | Biological process | small GTPase-mediated signal transduction |
GO_0090630 | Biological process | activation of GTPase activity |
GO_0098978 | Cellular component | glutamatergic synapse |
GO_0030424 | Cellular component | axon |
GO_0005829 | Cellular component | cytosol |
GO_0098685 | Cellular component | Schaffer collateral - CA1 synapse |
GO_0043197 | Cellular component | dendritic spine |
GO_0016020 | Cellular component | membrane |
GO_0005085 | Molecular function | guanyl-nucleotide exchange factor activity |
GO_0005515 | Molecular function | protein binding |
GO_0005096 | Molecular function | GTPase activator activity |
Gene name | ABR |
Protein name | ABR activator of RhoGEF and GTPase (Active breakpoint cluster region-related protein) Active breakpoint cluster region-related protein ABR activator of RhoGEF and GTPase |
Synonyms | |
Description | FUNCTION: Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form . The central Dbl homology (DH) domain functions as a guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form . Functions as an important negative regulator of neuronal RAC1 activity (By similarity). Regulates macrophage functions such as CSF-1 directed motility and phagocytosis through the modulation of RAC1 activity (By similarity). . |
Accessions | Q12979 ENST00000631205.2 ENST00000625740.2 [Q12979-2] ENST00000627795.2 ENST00000630420.2 A0A0G2JRJ1 ENST00000620619.4 [Q12979-4] ENST00000631336.2 ENST00000619569.4 ENST00000628370.2 ENST00000627848.2 I3L2P5 ENST00000627258.2 [Q12979-4] ENST00000571945.5 A0A0G2JSE0 A0A0G2JQB5 ENST00000627499.1 ENST00000572152.5 I3L4Y1 A0A0D9SGD7 ENST00000627242.2 ENST00000544583.6 [Q12979-4] ENST00000629473.1 ENST00000612118.4 [Q12979-1] A0A0G2JQM3 ENST00000574544.1 ENST00000628817.2 ENST00000570525.5 I3L2C0 ENST00000630943.2 ENST00000611021.3 [Q12979-2] ENST00000543210.6 [Q12979-3] A0A0G2JRW2 A0A0G2JRC2 ENST00000572441.5 ENST00000628588.2 I3L379 ENST00000302538.10 [Q12979-1] ENST00000613981.3 ENST00000627424.2 I3NI05 ENST00000630524.1 ENST00000536794.6 I3L1U8 ENST00000625562.2 A0A1C7CYZ0 ENST00000625685.2 ENST00000630902.2 I3L2L3 ENST00000626654.2 ENST00000571797.5 B7Z683 ENST00000631260.2 ENST00000575770.5 ENST00000629906.2 ENST00000574139.7 ENST00000626570.1 ENST00000615642.4 [Q12979-3] A0A0G2JQ41 A0A0G2JQT5 ENST00000574266.1 ENST00000575934.5 ENST00000611009.4 [Q12979-3] ENST00000574437.5 ENST00000630582.2 ENST00000628400.2 I3L259 ENST00000627102.2 ENST00000291107.6 [Q12979-2] I3L3W0 I3L0R7 ENST00000570441.5 ENST00000620170.4 |