ABR report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051056Biological processregulation of small GTPase mediated signal transduction
GO_0050804Biological processmodulation of chemical synaptic transmission
GO_0007264Biological processsmall GTPase-mediated signal transduction
GO_0090630Biological processactivation of GTPase activity
GO_0098978Cellular componentglutamatergic synapse
GO_0030424Cellular componentaxon
GO_0005829Cellular componentcytosol
GO_0098685Cellular componentSchaffer collateral - CA1 synapse
GO_0043197Cellular componentdendritic spine
GO_0016020Cellular componentmembrane
GO_0005085Molecular functionguanyl-nucleotide exchange factor activity
GO_0005515Molecular functionprotein binding
GO_0005096Molecular functionGTPase activator activity

IV. Literature review

[source]
Gene nameABR
Protein nameABR activator of RhoGEF and GTPase (Active breakpoint cluster region-related protein)
Active breakpoint cluster region-related protein
ABR activator of RhoGEF and GTPase
Synonyms
DescriptionFUNCTION: Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form . The central Dbl homology (DH) domain functions as a guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form . Functions as an important negative regulator of neuronal RAC1 activity (By similarity). Regulates macrophage functions such as CSF-1 directed motility and phagocytosis through the modulation of RAC1 activity (By similarity). .

AccessionsQ12979
ENST00000631205.2
ENST00000625740.2 [Q12979-2]
ENST00000627795.2
ENST00000630420.2
A0A0G2JRJ1
ENST00000620619.4 [Q12979-4]
ENST00000631336.2
ENST00000619569.4
ENST00000628370.2
ENST00000627848.2
I3L2P5
ENST00000627258.2 [Q12979-4]
ENST00000571945.5
A0A0G2JSE0
A0A0G2JQB5
ENST00000627499.1
ENST00000572152.5
I3L4Y1
A0A0D9SGD7
ENST00000627242.2
ENST00000544583.6 [Q12979-4]
ENST00000629473.1
ENST00000612118.4 [Q12979-1]
A0A0G2JQM3
ENST00000574544.1
ENST00000628817.2
ENST00000570525.5
I3L2C0
ENST00000630943.2
ENST00000611021.3 [Q12979-2]
ENST00000543210.6 [Q12979-3]
A0A0G2JRW2
A0A0G2JRC2
ENST00000572441.5
ENST00000628588.2
I3L379
ENST00000302538.10 [Q12979-1]
ENST00000613981.3
ENST00000627424.2
I3NI05
ENST00000630524.1
ENST00000536794.6
I3L1U8
ENST00000625562.2
A0A1C7CYZ0
ENST00000625685.2
ENST00000630902.2
I3L2L3
ENST00000626654.2
ENST00000571797.5
B7Z683
ENST00000631260.2
ENST00000575770.5
ENST00000629906.2
ENST00000574139.7
ENST00000626570.1
ENST00000615642.4 [Q12979-3]
A0A0G2JQ41
A0A0G2JQT5
ENST00000574266.1
ENST00000575934.5
ENST00000611009.4 [Q12979-3]
ENST00000574437.5
ENST00000630582.2
ENST00000628400.2
I3L259
ENST00000627102.2
ENST00000291107.6 [Q12979-2]
I3L3W0
I3L0R7
ENST00000570441.5
ENST00000620170.4