ALS2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051260Biological processprotein homooligomerization
GO_0051036Biological processregulation of endosome size
GO_0043547Biological processpositive regulation of GTPase activity
GO_0007041Biological processlysosomal transport
GO_0035022Biological processpositive regulation of Rac protein signal transduction
GO_0007528Biological processneuromuscular junction development
GO_0045860Biological processpositive regulation of protein kinase activity
GO_0048812Biological processneuron projection morphogenesis
GO_0016197Biological processendosomal transport
GO_0043087Biological processregulation of GTPase activity
GO_0007032Biological processendosome organization
GO_0007626Biological processlocomotory behavior
GO_0001662Biological processbehavioral fear response
GO_0008104Biological processprotein localization
GO_0006979Biological processresponse to oxidative stress
GO_0001881Biological processreceptor recycling
GO_0035249Biological processsynaptic transmission, glutamatergic
GO_0001726Cellular componentruffle
GO_0031982Cellular componentvesicle
GO_0043197Cellular componentdendritic spine
GO_0005769Cellular componentearly endosome
GO_0005813Cellular componentcentrosome
GO_0032991Cellular componentprotein-containing complex
GO_0030425Cellular componentdendrite
GO_0005829Cellular componentcytosol
GO_0014069Cellular componentpostsynaptic density
GO_0030426Cellular componentgrowth cone
GO_0005737Cellular componentcytoplasm
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0030027Cellular componentlamellipodium
GO_0005634Cellular componentnucleus
GO_0042803Molecular functionprotein homodimerization activity
GO_0005085Molecular functionguanyl-nucleotide exchange factor activity
GO_0042802Molecular functionidentical protein binding
GO_0031267Molecular functionsmall GTPase binding
GO_0005096Molecular functionGTPase activator activity
GO_0043539Molecular functionprotein serine/threonine kinase activator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameALS2
Protein nameAlsin (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 6 protein) (Amyotrophic lateral sclerosis 2 protein)
ALS2
Alsin Rho guanine nucleotide exchange factor ALS2 (Amyotrophic lateral sclerosis 2 isoform 2)
Alsin
Alsin Rho guanine nucleotide exchange factor ALS2
Alsin Rho guanine nucleotide exchange factor ALS2 (Amyotrophic lateral sclerosis 2 isoform 1)
ALS2 protein
SynonymsALS2CR6
KIAA1563
DescriptionFUNCTION: May act as a GTPase regulator. Controls survival and growth of spinal motoneurons (By similarity). .

AccessionsA0A7P0T8W6
ENST00000681768.1
A0A7P0Z4I4
ENST00000679516.1 [Q96Q42-1]
ENST00000467448.5 [Q96Q42-2]
A0A7P0T993
ENST00000680644.1
A0A7P0Z499
ENST00000681152.1
A0A7P0T958
A0A0S2Z5I4
J3KQ43
A0A7P0TBK0
A0A7P0T9V4
Q6IQ41
ENST00000679939.1
ENST00000681144.1
A0A0S2Z5Q7
ENST00000680726.1
J3KQ33
ENST00000679618.1
ENST00000679916.1
A0A7P0TAC4
A0A7P0T9R1
ENST00000680236.1
ENST00000679435.1 [Q96Q42-1]
ENST00000679409.1
ENST00000264276.11 [Q96Q42-1]
A0A7P0TAM1
H0Y696
A0A7P0TAH8
ENST00000680135.1
Q96Q42
A0A7P0T8T2
ENST00000680569.1
ENST00000410052.1
ENST00000680759.1
ENST00000680287.1
A0A7P0T9P3
A0A7P0T813
ENST00000681619.1
ENST00000439495.6
ENST00000679949.1
A0A7P0T8P3
ENST00000680814.1
A0A7P0T976
A0A7P0Z4F3
ENST00000681256.1
ENST00000681250.1
A0A7P0T951
A0A7P0T9K3
ENST00000680163.1 [Q96Q42-1]
ENST00000680828.1
A0A7P0TBB0
ENST00000680861.1 [Q96Q42-1]
A0A7P0Z4J9
ENST00000680927.1
ENST00000681808.1
ENST00000679503.1 [Q96Q42-2]
ENST00000680188.1 [Q96Q42-2]
ENST00000681558.1
ENST00000681716.1
A0A7P0Z4M6
ENST00000679728.1
ENST00000680149.1
A0A7P0T980
ENST00000680497.1
ENST00000681312.1
A0A7P0T8R1
A0A7P0T8F3
ENST00000681495.1
ENST00000409632
A0A7P0T9U5
ENST00000680000.1
A0A2X0SFA0
ENST00000679550.1
ENST00000409632.7 [Q96Q42-2]
ENST00000681303.1
ENST00000680508.1