SH2D3C report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SH2D3C at tissue level.

III. Associated gene sets

GO_0033138Biological processpositive regulation of peptidyl-serine phosphorylation
GO_0007254Biological processJNK cascade
GO_0007264Biological processsmall GTPase-mediated signal transduction
GO_0032587Cellular componentruffle membrane
GO_0030424Cellular componentaxon
GO_0005829Cellular componentcytosol
GO_0005085Molecular functionguanyl-nucleotide exchange factor activity
GO_0005515Molecular functionprotein binding
GO_0001784Molecular functionphosphotyrosine residue binding

IV. Literature review

[source]
Gene nameSH2D3C
Protein nameSH2 domain containing 3C
SH2 domain-containing protein 3C (Cas/HEF1-associated signal transducer) (Chat-H) (Novel SH2-containing protein 3) (SH2 domain-containing Eph receptor-binding protein 1) (SHEP1)
SynonymsNSP3
UNQ272/PRO309/PRO34088
DescriptionFUNCTION: Acts as an adapter protein that mediates cell signaling pathways involved in cellular functions such as cell adhesion and migration, tissue organization, and the regulation of the immune response . Plays a role in integrin-mediated cell adhesion through BCAR1-CRK-RAPGEF1 signaling and activation of the small GTPase RAP1 . Promotes cell migration and invasion through the extracellular matrix . Required for marginal zone B-cell development and thymus-independent type 2 immune responses (By similarity). Mediates migration and adhesion of B cells in the splenic marginal zone via promoting hyperphosphorylation of NEDD9/CASL (By similarity). Plays a role in CXCL13-induced chemotaxis of B-cells (By similarity). Plays a role in the migration of olfactory sensory neurons (OSNs) into the forebrain and the innervation of the olfactory bulb by the OSN axons during development (By similarity). Required for the efficient tyrosine phosphorylation of BCAR1 in OSN axons (By similarity). .; FUNCTION: [Isoform 1]: Important regulator of chemokine-induced, integrin-mediated T lymphocyte adhesion and migration, acting upstream of RAP1 (By similarity). Required for tissue-specific adhesion of T lymphocytes to peripheral tissues (By similarity). Required for basal and CXCL2 stimulated serine-threonine phosphorylation of NEDD9 (By similarity). May be involved in the regulation of T-cell receptor-mediated IL2 production through the activation of the JNK pathway in T-cells (By similarity). .; FUNCTION: [Isoform 2]: May be involved in the BCAR1/CAS-mediated JNK activation pathway. .

AccessionsENST00000373276.7 [Q8N5H7-4]
ENST00000429553.5 [Q8N5H7-3]
ENST00000629203.2 [Q8N5H7-6]
ENST00000314830.13 [Q8N5H7-1]
ENST00000414380.1
ENST00000373277.8 [Q8N5H7-2]
Q5JU32
ENST00000440630.5
ENST00000420366.5 [Q8N5H7-5]
Q8N5H7
H0Y5X5