GZMB report

II. Expression across tissues

III. Associated gene sets

GO_0140507Biological processgranzyme-mediated programmed cell death signaling pathway
GO_0070269Biological processpyroptotic inflammatory response
GO_0042267Biological processnatural killer cell mediated cytotoxicity
GO_0031640Biological processkilling of cells of another organism
GO_0006915Biological processapoptotic process
GO_0051603Biological processproteolysis involved in protein catabolic process
GO_0017148Biological processnegative regulation of translation
GO_0051604Biological processprotein maturation
GO_0001772Cellular componentimmunological synapse
GO_0044194Cellular componentcytolytic granule
GO_0005576Cellular componentextracellular region
GO_0016020Cellular componentmembrane
GO_1904856Cellular componentcytolytic granule lumen
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005634Cellular componentnucleus
GO_0008236Molecular functionserine-type peptidase activity
GO_0005515Molecular functionprotein binding
GO_0004252Molecular functionserine-type endopeptidase activity

IV. Literature review

[source]
Gene nameGZMB
Protein nameGranzyme B (EC 3.4.21.79) (C11) (CTLA-1) (Cathepsin G-like 1) (CTSGL1) (Cytotoxic T-lymphocyte proteinase 2) (Lymphocyte protease) (Fragmentin-2) (Granzyme-2) (Human lymphocyte protein) (HLP) (SECT) (T-cell serine protease 1-3E)
Granzyme B
SynonymsCGL1
CTLA1
CSPB
hCG_40183
GRB
DescriptionFUNCTION: Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent pyroptosis when delivered into the target cell through the immunological synapse . It cleaves after Asp . Once delivered into the target cell, acts by catalyzing cleavage of gasdermin-E (GSDME), releasing the pore-forming moiety of GSDME, thereby triggering pyroptosis and target cell death . Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -9 and -10 (CASP3, CASP9 and CASP10, respectively) to give rise to active enzymes mediating apoptosis . Cleaves and activates CASP7 in response to bacterial infection, promoting plasma membrane repair (By similarity). .

AccessionsP10144
ENST00000415355.7
E9PID1
ENST00000382540.5
J3KPK2
ENST00000216341.9
ENST00000530830.1
E9PRD7
ENST00000554242.5
J3KQ52
ENST00000532263.5
E9PLX4
ENST00000526004.1