Name | Number of supported studies | Average coverage | |
---|---|---|---|
natural killer cell | 48 studies | 72% ± 24% | |
plasmacytoid dendritic cell | 29 studies | 86% ± 14% | |
CD8-positive, alpha-beta T cell | 26 studies | 43% ± 21% | |
mature NK T cell | 18 studies | 67% ± 21% | |
CD16-positive, CD56-dim natural killer cell, human | 17 studies | 82% ± 19% | |
T cell | 15 studies | 33% ± 10% | |
CD16-negative, CD56-bright natural killer cell, human | 15 studies | 55% ± 18% | |
gamma-delta T cell | 15 studies | 46% ± 12% | |
CD8-positive, alpha-beta memory T cell | 11 studies | 37% ± 11% | |
effector memory CD8-positive, alpha-beta T cell | 8 studies | 39% ± 16% | |
effector CD8-positive, alpha-beta T cell | 7 studies | 70% ± 15% | |
effector memory CD8-positive, alpha-beta T cell, terminally differentiated | 5 studies | 57% ± 6% | |
innate lymphoid cell | 5 studies | 41% ± 12% | |
exhausted T cell | 4 studies | 39% ± 26% | |
naive thymus-derived CD8-positive, alpha-beta T cell | 4 studies | 39% ± 26% | |
mucosal invariant T cell | 3 studies | 22% ± 3% | |
CD4-positive, alpha-beta T cell | 3 studies | 41% ± 17% | |
CD4-positive, alpha-beta memory T cell | 3 studies | 27% ± 5% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
lung | 100% | 614.17 | 576 / 578 | 86% | 26.61 | 992 / 1155 |
stomach | 78% | 96.12 | 281 / 359 | 82% | 34.91 | 235 / 286 |
intestine | 52% | 61.55 | 506 / 966 | 83% | 29.76 | 435 / 527 |
esophagus | 57% | 58.00 | 824 / 1445 | 73% | 15.41 | 134 / 183 |
kidney | 70% | 47.42 | 62 / 89 | 55% | 8.82 | 496 / 901 |
bladder | 57% | 37.48 | 12 / 21 | 66% | 30.97 | 333 / 504 |
uterus | 48% | 30.31 | 81 / 170 | 75% | 35.32 | 344 / 459 |
breast | 82% | 84.71 | 375 / 459 | 38% | 10.04 | 427 / 1118 |
thymus | 82% | 80.70 | 537 / 653 | 30% | 5.64 | 182 / 605 |
spleen | 100% | 980.36 | 241 / 241 | 0% | 0 | 0 / 0 |
liver | 81% | 84.38 | 182 / 226 | 17% | 2.87 | 68 / 406 |
lymph node | 0% | 0 | 0 / 0 | 97% | 244.53 | 28 / 29 |
adipose | 90% | 118.95 | 1078 / 1204 | 0% | 0 | 0 / 0 |
peripheral blood | 89% | 4660.75 | 827 / 929 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 89% | 55.20 | 40 / 45 |
prostate | 68% | 56.93 | 167 / 245 | 19% | 1.76 | 94 / 502 |
skin | 13% | 6.75 | 238 / 1809 | 65% | 28.52 | 305 / 472 |
ovary | 16% | 8.41 | 29 / 180 | 48% | 7.59 | 206 / 430 |
pancreas | 11% | 5.35 | 35 / 328 | 47% | 8.55 | 84 / 178 |
heart | 50% | 33.69 | 433 / 861 | 0% | 0 | 0 / 0 |
blood vessel | 39% | 30.62 | 524 / 1335 | 0% | 0 | 0 / 0 |
adrenal gland | 25% | 12.32 | 64 / 258 | 7% | 1.23 | 16 / 230 |
brain | 26% | 17.86 | 693 / 2642 | 5% | 0.99 | 36 / 705 |
muscle | 20% | 9.13 | 161 / 803 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 10% | 1.33 | 8 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0140507 | Biological process | granzyme-mediated programmed cell death signaling pathway |
GO_0070269 | Biological process | pyroptotic inflammatory response |
GO_0042267 | Biological process | natural killer cell mediated cytotoxicity |
GO_0031640 | Biological process | killing of cells of another organism |
GO_0006915 | Biological process | apoptotic process |
GO_0051603 | Biological process | proteolysis involved in protein catabolic process |
GO_0017148 | Biological process | negative regulation of translation |
GO_0051604 | Biological process | protein maturation |
GO_0001772 | Cellular component | immunological synapse |
GO_0044194 | Cellular component | cytolytic granule |
GO_0005576 | Cellular component | extracellular region |
GO_0016020 | Cellular component | membrane |
GO_1904856 | Cellular component | cytolytic granule lumen |
GO_0005829 | Cellular component | cytosol |
GO_0005737 | Cellular component | cytoplasm |
GO_0043231 | Cellular component | intracellular membrane-bounded organelle |
GO_0005634 | Cellular component | nucleus |
GO_0008236 | Molecular function | serine-type peptidase activity |
GO_0005515 | Molecular function | protein binding |
GO_0004252 | Molecular function | serine-type endopeptidase activity |
Gene name | GZMB |
Protein name | Granzyme B (EC 3.4.21.79) (C11) (CTLA-1) (Cathepsin G-like 1) (CTSGL1) (Cytotoxic T-lymphocyte proteinase 2) (Lymphocyte protease) (Fragmentin-2) (Granzyme-2) (Human lymphocyte protein) (HLP) (SECT) (T-cell serine protease 1-3E) Granzyme B |
Synonyms | CGL1 CTLA1 CSPB hCG_40183 GRB |
Description | FUNCTION: Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent pyroptosis when delivered into the target cell through the immunological synapse . It cleaves after Asp . Once delivered into the target cell, acts by catalyzing cleavage of gasdermin-E (GSDME), releasing the pore-forming moiety of GSDME, thereby triggering pyroptosis and target cell death . Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -9 and -10 (CASP3, CASP9 and CASP10, respectively) to give rise to active enzymes mediating apoptosis . Cleaves and activates CASP7 in response to bacterial infection, promoting plasma membrane repair (By similarity). . |
Accessions | P10144 ENST00000415355.7 E9PID1 ENST00000382540.5 J3KPK2 ENST00000216341.9 ENST00000530830.1 E9PRD7 ENST00000554242.5 J3KQ52 ENST00000532263.5 E9PLX4 ENST00000526004.1 |