TIGIT report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TIGIT at tissue level.

III. Associated gene sets

GO_0050868Biological processnegative regulation of T cell activation
GO_0032695Biological processnegative regulation of interleukin-12 production
GO_0032733Biological processpositive regulation of interleukin-10 production
GO_0009986Cellular componentcell surface
GO_0005886Cellular componentplasma membrane
GO_0042802Molecular functionidentical protein binding
GO_0005102Molecular functionsignaling receptor binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTIGIT
Protein nameT cell immunoreceptor with Ig and ITIM domains
T-cell immunoreceptor with Ig and ITIM domains (V-set and immunoglobulin domain-containing protein 9) (V-set and transmembrane domain-containing protein 3)
SynonymsVSIG9
VSTM3
DescriptionFUNCTION: Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells. .

AccessionsENST00000484319.1
ENST00000383671.8 [Q495A1-1]
ENST00000481065.5
ENST00000486257.5 [Q495A1-1]
A0A0C4DGA4
Q495A1
C9J0B0
ENST00000461158.5
C9JZW6