Name | Number of supported studies | Average coverage | |
---|---|---|---|
regulatory T cell | 26 studies | 45% ± 16% | |
natural killer cell | 21 studies | 20% ± 6% | |
CD8-positive, alpha-beta T cell | 18 studies | 25% ± 8% | |
CD16-positive, CD56-dim natural killer cell, human | 8 studies | 23% ± 5% | |
CD16-negative, CD56-bright natural killer cell, human | 8 studies | 27% ± 10% | |
gamma-delta T cell | 8 studies | 31% ± 14% | |
CD8-positive, alpha-beta memory T cell | 7 studies | 27% ± 7% | |
mature NK T cell | 7 studies | 20% ± 3% | |
T follicular helper cell | 7 studies | 41% ± 18% | |
T cell | 6 studies | 27% ± 12% | |
effector CD8-positive, alpha-beta T cell | 6 studies | 30% ± 16% | |
exhausted T cell | 4 studies | 43% ± 15% | |
effector memory CD8-positive, alpha-beta T cell | 4 studies | 27% ± 4% | |
effector CD4-positive, alpha-beta T cell | 3 studies | 21% ± 5% |
Insufficient scRNA-seq data for expression of TIGIT at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
lung | 100% | 233.24 | 576 / 578 | 89% | 4.64 | 1025 / 1155 |
breast | 72% | 49.32 | 331 / 459 | 72% | 4.23 | 810 / 1118 |
stomach | 79% | 55.78 | 282 / 359 | 66% | 2.22 | 188 / 286 |
uterus | 69% | 38.92 | 118 / 170 | 73% | 3.84 | 333 / 459 |
thymus | 81% | 150.25 | 531 / 653 | 54% | 2.44 | 329 / 605 |
intestine | 62% | 229.57 | 601 / 966 | 61% | 2.14 | 324 / 527 |
prostate | 81% | 84.93 | 198 / 245 | 39% | 1.11 | 198 / 502 |
bladder | 52% | 65.62 | 11 / 21 | 65% | 2.85 | 327 / 504 |
liver | 82% | 52.35 | 186 / 226 | 30% | 1.24 | 123 / 406 |
skin | 41% | 20.25 | 747 / 1809 | 69% | 7.03 | 325 / 472 |
kidney | 55% | 66.48 | 49 / 89 | 55% | 2.44 | 492 / 901 |
esophagus | 43% | 31.13 | 628 / 1445 | 61% | 2.02 | 111 / 183 |
lymph node | 0% | 0 | 0 / 0 | 100% | 39.36 | 29 / 29 |
spleen | 100% | 1190.53 | 241 / 241 | 0% | 0 | 0 / 0 |
peripheral blood | 98% | 673.77 | 913 / 929 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 93% | 9.33 | 42 / 45 |
adipose | 85% | 79.73 | 1019 / 1204 | 0% | 0 | 0 / 0 |
pancreas | 8% | 2.73 | 25 / 328 | 69% | 3.22 | 123 / 178 |
ovary | 28% | 11.58 | 50 / 180 | 30% | 0.65 | 129 / 430 |
brain | 41% | 20.38 | 1071 / 2642 | 10% | 0.26 | 67 / 705 |
blood vessel | 44% | 36.08 | 585 / 1335 | 0% | 0 | 0 / 0 |
adrenal gland | 23% | 9.04 | 60 / 258 | 7% | 0.14 | 15 / 230 |
heart | 29% | 13.60 | 246 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 14% | 0.70 | 11 / 80 |
muscle | 3% | 1.13 | 25 / 803 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0050868 | Biological process | negative regulation of T cell activation |
GO_0032695 | Biological process | negative regulation of interleukin-12 production |
GO_0032733 | Biological process | positive regulation of interleukin-10 production |
GO_0009986 | Cellular component | cell surface |
GO_0005886 | Cellular component | plasma membrane |
GO_0042802 | Molecular function | identical protein binding |
GO_0005102 | Molecular function | signaling receptor binding |
GO_0005515 | Molecular function | protein binding |
Gene name | TIGIT |
Protein name | T cell immunoreceptor with Ig and ITIM domains T-cell immunoreceptor with Ig and ITIM domains (V-set and immunoglobulin domain-containing protein 9) (V-set and transmembrane domain-containing protein 3) |
Synonyms | VSIG9 VSTM3 |
Description | FUNCTION: Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells. . |
Accessions | ENST00000484319.1 ENST00000383671.8 [Q495A1-1] ENST00000481065.5 ENST00000486257.5 [Q495A1-1] A0A0C4DGA4 Q495A1 C9J0B0 ENST00000461158.5 C9JZW6 |