CD8B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006955Biological processimmune response
GO_0002250Biological processadaptive immune response
GO_0007169Biological processcell surface receptor protein tyrosine kinase signaling pathway
GO_0050852Biological processT cell receptor signaling pathway
GO_0042110Biological processT cell activation
GO_0009986Cellular componentcell surface
GO_0031901Cellular componentearly endosome membrane
GO_0042101Cellular componentT cell receptor complex
GO_0043235Cellular componentreceptor complex
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0015026Molecular functioncoreceptor activity
GO_0042288Molecular functionMHC class I protein binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCD8B
Protein nameCD8 subunit beta
CD8 antigen
T-cell surface glycoprotein CD8 beta chain (CD antigen CD8b)
SynonymsCD8B1
DescriptionFUNCTION: Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. A palmitoylation site in the cytoplasmic tail of CD8B chain contributes to partitioning of CD8 into the plasma membrane lipid rafts where signaling proteins are enriched. Once LCK recruited, it initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). Additionally, plays a critical role in thymic selection of CD8+ T-cells. .

AccessionsENST00000393761.6 [P10966-9]
P10966
ENST00000431506.3
ENST00000393759.6 [P10966-2]
E9PD41
ENST00000390655.12 [P10966-1]
ENST00000331469.6 [P10966-6]
A0N2Q4
ENST00000349455.7 [P10966-3]