GZMH report

II. Expression across tissues

III. Associated gene sets

GO_0006915Biological processapoptotic process
GO_0031640Biological processkilling of cells of another organism
GO_0006508Biological processproteolysis
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0044194Cellular componentcytolytic granule
GO_0016020Cellular componentmembrane
GO_0005737Cellular componentcytoplasm
GO_0004252Molecular functionserine-type endopeptidase activity

IV. Literature review

[source]
Gene nameGZMH
Protein nameGranzyme H
Granzyme H (EC 3.4.21.-) (CCP-X) (Cathepsin G-like 2) (CTSGL2) (Cytotoxic T-lymphocyte proteinase) (Cytotoxic serine protease C) (CSP-C)
SynonymsCGL2
CTSGL2
DescriptionFUNCTION: Cytotoxic chymotrypsin-like serine protease with preference for bulky and aromatic residues at the P1 position and acidic residues at the P3' and P4' sites. Probably necessary for target cell lysis in cell-mediated immune responses. Participates in the antiviral response via direct cleavage of several proteins essential for viral replication. .

AccessionsENST00000557220.6
ENST00000382548.4 [P20718-2]
P20718
ENST00000216338.9 [P20718-1]
A0A0C4DGJ9