ZAP70 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007169Biological processcell surface receptor protein tyrosine kinase signaling pathway
GO_0050850Biological processpositive regulation of calcium-mediated signaling
GO_0019722Biological processcalcium-mediated signaling
GO_0045582Biological processpositive regulation of T cell differentiation
GO_0045087Biological processinnate immune response
GO_0070489Biological processT cell aggregation
GO_0050852Biological processT cell receptor signaling pathway
GO_0006955Biological processimmune response
GO_0002250Biological processadaptive immune response
GO_0030217Biological processT cell differentiation
GO_0018108Biological processpeptidyl-tyrosine phosphorylation
GO_0043366Biological processbeta selection
GO_0035556Biological processintracellular signal transduction
GO_0030154Biological processcell differentiation
GO_0046641Biological processpositive regulation of alpha-beta T cell proliferation
GO_0042113Biological processB cell activation
GO_0045060Biological processnegative thymic T cell selection
GO_0045059Biological processpositive thymic T cell selection
GO_0006468Biological processprotein phosphorylation
GO_0046638Biological processpositive regulation of alpha-beta T cell differentiation
GO_0072678Biological processT cell migration
GO_0042110Biological processT cell activation
GO_0001772Cellular componentimmunological synapse
GO_0005886Cellular componentplasma membrane
GO_0045121Cellular componentmembrane raft
GO_0031234Cellular componentextrinsic component of cytoplasmic side of plasma membrane
GO_0005911Cellular componentcell-cell junction
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0042101Cellular componentT cell receptor complex
GO_0004715Molecular functionnon-membrane spanning protein tyrosine kinase activity
GO_0004713Molecular functionprotein tyrosine kinase activity
GO_0005102Molecular functionsignaling receptor binding
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding
GO_0001784Molecular functionphosphotyrosine residue binding

IV. Literature review

[source]
Gene nameZAP70
Protein nameTyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-chain associated protein) (Syk-related tyrosine kinase)
SynonymsSRK
DescriptionFUNCTION: Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates motility, adhesion and cytokine expression of mature T-cells, as well as thymocyte development. Contributes also to the development and activation of primary B-lymphocytes. When antigen presenting cells (APC) activate T-cell receptor (TCR), a serie of phosphorylations lead to the recruitment of ZAP70 to the doubly phosphorylated TCR component CD247/CD3Z through ITAM motif at the plasma membrane. This recruitment serves to localization to the stimulated TCR and to relieve its autoinhibited conformation. Release of ZAP70 active conformation is further stabilized by phosphorylation mediated by LCK. Subsequently, ZAP70 phosphorylates at least 2 essential adapter proteins: LAT and LCP2. In turn, a large number of signaling molecules are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation. Furthermore, ZAP70 controls cytoskeleton modifications, adhesion and mobility of T-lymphocytes, thus ensuring correct delivery of effectors to the APC. ZAP70 is also required for TCR-CD247/CD3Z internalization and degradation through interaction with the E3 ubiquitin-protein ligase CBL and adapter proteins SLA and SLA2. Thus, ZAP70 regulates both T-cell activation switch on and switch off by modulating TCR expression at the T-cell surface. During thymocyte development, ZAP70 promotes survival and cell-cycle progression of developing thymocytes before positive selection (when cells are still CD4/CD8 double negative). Additionally, ZAP70-dependent signaling pathway may also contribute to primary B-cells formation and activation through B-cell receptor (BCR). .

AccessionsENST00000708159.1 [P43403-2]
ENST00000698508.1 [P43403-1]
ENST00000264972.10 [P43403-1]
P43403
ENST00000708154.1 [P43403-1]
ENST00000451498.2 [P43403-2]
ENST00000708152.1 [P43403-1]