CD6 | OmnibusX

Name	Number of supported studies	Average coverage
CD4-positive, alpha-beta T cell	32 studies	32% ± 10%	Explore
CD8-positive, alpha-beta T cell	27 studies	27% ± 11%	Explore
T cell	25 studies	28% ± 9%	Explore
regulatory T cell	21 studies	27% ± 9%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	14 studies	31% ± 8%	Explore
mucosal invariant T cell	12 studies	30% ± 9%	Explore
CD4-positive, alpha-beta memory T cell	11 studies	33% ± 10%	Explore
CD8-positive, alpha-beta memory T cell	11 studies	30% ± 7%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	10 studies	29% ± 7%	Explore
mature NK T cell	9 studies	23% ± 8%	Explore
effector memory CD8-positive, alpha-beta T cell	7 studies	28% ± 11%	Explore
T follicular helper cell	7 studies	39% ± 5%	Explore
gamma-delta T cell	7 studies	27% ± 7%	Explore
CD4-positive helper T cell	6 studies	26% ± 9%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	34% ± 15%	Explore
exhausted T cell	5 studies	28% ± 8%	Explore
natural killer cell	5 studies	22% ± 4%	Explore
effector CD8-positive, alpha-beta T cell	4 studies	25% ± 3%	Explore
T-helper 17 cell	4 studies	31% ± 10%	Explore
T-helper 1 cell	4 studies	39% ± 11%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	24% ± 4%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	37% ± 11%	Explore
effector CD4-positive, alpha-beta T cell	3 studies	32% ± 2%	Explore
lymphocyte	3 studies	28% ± 9%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	25% ± 14%	Explore

Name	Number of supported studies	Average coverage
peripheral blood	11 studies	19% ± 3%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	100%	830.33	577 / 578	90%	7.53	1038 / 1155
stomach	86%	274.84	310 / 359	80%	5.34	228 / 286
breast	78%	152.36	356 / 459	75%	6.24	839 / 1118
intestine	68%	740.83	653 / 966	79%	4.77	418 / 527
thymus	91%	310.43	592 / 653	55%	9.18	335 / 605
kidney	72%	186.67	64 / 89	71%	4.54	641 / 901
uterus	64%	82.98	108 / 170	73%	5.30	337 / 459
prostate	86%	213.86	211 / 245	48%	2.28	240 / 502
pancreas	43%	44.74	141 / 328	80%	6.46	143 / 178
skin	51%	82.00	925 / 1809	65%	7.58	305 / 472
esophagus	47%	109.31	685 / 1445	68%	3.75	125 / 183
bladder	52%	211.76	11 / 21	60%	4.09	300 / 504
liver	72%	95.65	162 / 226	35%	2.15	144 / 406
lymph node	0%	0	0 / 0	100%	37.47	29 / 29
spleen	100%	3068.80	241 / 241	0%	0	0 / 0
peripheral blood	99%	2807.43	918 / 929	0%	0	0 / 0
ovary	49%	61.81	89 / 180	47%	2.44	202 / 430
adipose	90%	222.18	1089 / 1204	0%	0	0 / 0
tonsil	0%	0	0 / 0	84%	13.62	38 / 45
brain	48%	80.68	1263 / 2642	8%	0.31	57 / 705
adrenal gland	45%	51.09	117 / 258	9%	0.31	21 / 230
blood vessel	39%	89.79	519 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	26%	1.27	21 / 80
heart	18%	23.00	152 / 861	0%	0	0 / 0
muscle	2%	1.98	15 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0031663	Biological process	lipopolysaccharide-mediated signaling pathway
GO_0042102	Biological process	positive regulation of T cell proliferation
GO_0001771	Biological process	immunological synapse formation
GO_0045087	Biological process	innate immune response
GO_0001934	Biological process	positive regulation of protein phosphorylation
GO_1900017	Biological process	positive regulation of cytokine production involved in inflammatory response
GO_0002250	Biological process	adaptive immune response
GO_0007157	Biological process	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
GO_0032496	Biological process	response to lipopolysaccharide
GO_0002438	Biological process	acute inflammatory response to antigenic stimulus
GO_0001772	Cellular component	immunological synapse
GO_0005576	Cellular component	extracellular region
GO_0005886	Cellular component	plasma membrane
GO_0009986	Cellular component	cell surface
GO_0042101	Cellular component	T cell receptor complex
GO_0019901	Molecular function	protein kinase binding
GO_0042802	Molecular function	identical protein binding
GO_0001530	Molecular function	lipopolysaccharide binding
GO_0070891	Molecular function	lipoteichoic acid binding
GO_0005515	Molecular function	protein binding

Gene name	CD6
Protein name	CD6 molecule CD6 antigen, isoform CRA_d (CD6 molecule) Alternative protein CD6 CD6 protein T-cell differentiation antigen CD6 (T12) (TP120) (CD antigen CD6) [Cleaved into: Soluble CD6]
Synonyms	hCG_40393
Description	FUNCTION: Cell adhesion molecule that mediates cell-cell contacts and regulates T-cell responses via its interaction with ALCAM/CD166 . Contributes to signaling cascades triggered by activation of the TCR/CD3 complex . Functions as a costimulatory molecule; promotes T-cell activation and proliferation . Contributes to the formation and maturation of the immunological synapse . Functions as a calcium-dependent pattern receptor that binds and aggregates both Gram-positive and Gram-negative bacteria. Binds both lipopolysaccharide (LPS) from Gram-negative bacteria and lipoteichoic acid from Gram-positive bacteria . LPS binding leads to the activation of signaling cascades and down-stream MAP kinases . Mediates activation of the inflammatory response and the secretion of pro-inflammatory cytokines in response to LPS . .
Accessions	ENST00000433107.6 L8E9F6 ENST00000538611.1 G5E973 ENST00000452451.6 [P30203-5] E7ER04 F6UFK6 Q8N4Q7 F5H835 ENST00000352009.9 [P30203-4] ENST00000542254.5 P30203 ENST00000344931.9 H0YGL3 ENST00000542157.5 Q6AZ88 ENST00000313421.11 [P30203-1]

CD6 report