EOMES | OmnibusX

Name	Number of supported studies	Average coverage
natural killer cell	17 studies	27% ± 12%	Explore
CD16-negative, CD56-bright natural killer cell, human	8 studies	32% ± 17%	Explore
CD16-positive, CD56-dim natural killer cell, human	6 studies	25% ± 11%	Explore
CD8-positive, alpha-beta T cell	6 studies	26% ± 7%	Explore
exhausted T cell	4 studies	32% ± 1%	Explore
mature NK T cell	4 studies	28% ± 9%	Explore
CD8-positive, alpha-beta memory T cell	4 studies	25% ± 9%	Explore
effector CD8-positive, alpha-beta T cell	3 studies	20% ± 2%	Explore
mucosal invariant T cell	3 studies	21% ± 3%	Explore
T cell	3 studies	17% ± 1%	Explore

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of EOMES at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	99%	304.56	570 / 578	70%	2.49	808 / 1155
kidney	56%	60.19	50 / 89	65%	4.41	590 / 901
liver	92%	111.25	208 / 226	23%	0.72	95 / 406
breast	56%	45.10	259 / 459	58%	2.53	645 / 1118
uterus	59%	41.98	100 / 170	41%	1.55	190 / 459
spleen	100%	1582.23	241 / 241	0%	0	0 / 0
skin	8%	4.00	138 / 1809	89%	10.37	420 / 472
stomach	44%	29.00	158 / 359	51%	2.31	145 / 286
lymph node	0%	0	0 / 0	93%	27.44	27 / 29
bladder	57%	51.29	12 / 21	31%	0.89	158 / 504
peripheral blood	88%	938.90	818 / 929	0%	0	0 / 0
thymus	56%	83.45	368 / 653	31%	1.18	185 / 605
prostate	55%	50.60	135 / 245	29%	0.87	146 / 502
tonsil	0%	0	0 / 0	82%	5.08	37 / 45
pancreas	33%	16.69	107 / 328	46%	1.40	81 / 178
intestine	39%	59.08	380 / 966	37%	1.19	196 / 527
adipose	74%	100.33	888 / 1204	0%	0	0 / 0
esophagus	17%	8.85	240 / 1445	49%	1.35	90 / 183
adrenal gland	51%	34.06	132 / 258	12%	0.46	28 / 230
ovary	19%	13.02	35 / 180	33%	0.75	144 / 430
eye	0%	0	0 / 0	46%	2.45	37 / 80
blood vessel	46%	48.53	616 / 1335	0%	0	0 / 0
heart	30%	18.82	260 / 861	0%	0	0 / 0
brain	25%	431.54	669 / 2642	5%	0.14	34 / 705
muscle	2%	0.99	15 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0010002	Biological process	cardioblast differentiation
GO_0006357	Biological process	regulation of transcription by RNA polymerase II
GO_0001829	Biological process	trophectodermal cell differentiation
GO_0002302	Biological process	CD8-positive, alpha-beta T cell differentiation involved in immune response
GO_0001764	Biological process	neuron migration
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0043433	Biological process	negative regulation of DNA-binding transcription factor activity
GO_0006338	Biological process	chromatin remodeling
GO_0048708	Biological process	astrocyte differentiation
GO_0021772	Biological process	olfactory bulb development
GO_0048382	Biological process	mesendoderm development
GO_0002250	Biological process	adaptive immune response
GO_0045893	Biological process	positive regulation of DNA-templated transcription
GO_0001707	Biological process	mesoderm formation
GO_0019827	Biological process	stem cell population maintenance
GO_0021796	Biological process	cerebral cortex regionalization
GO_0060809	Biological process	mesodermal to mesenchymal transition involved in gastrulation
GO_0007420	Biological process	brain development
GO_0060706	Biological process	cell differentiation involved in embryonic placenta development
GO_0001706	Biological process	endoderm formation
GO_0010467	Biological process	gene expression
GO_0035914	Biological process	skeletal muscle cell differentiation
GO_0021895	Biological process	cerebral cortex neuron differentiation
GO_0001714	Biological process	endodermal cell fate specification
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0005654	Cellular component	nucleoplasm
GO_0000785	Cellular component	chromatin
GO_0005634	Cellular component	nucleus
GO_0003677	Molecular function	DNA binding
GO_0000978	Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0000981	Molecular function	DNA-binding transcription factor activity, RNA polymerase II-specific
GO_0043565	Molecular function	sequence-specific DNA binding
GO_1990837	Molecular function	sequence-specific double-stranded DNA binding
GO_0061629	Molecular function	RNA polymerase II-specific DNA-binding transcription factor binding
GO_0031490	Molecular function	chromatin DNA binding

IV. Literature review

[source]

Gene name	EOMES
Protein name	Eomesodermin homolog (T-box brain protein 2) (T-brain-2) (TBR-2)
Synonyms	TBR2
Description	FUNCTION: Functions as a transcriptional activator playing a crucial role during development. Functions in trophoblast differentiation and later in gastrulation, regulating both mesoderm delamination and endoderm specification. Plays a role in brain development being required for the specification and the proliferation of the intermediate progenitor cells and their progeny in the cerebral cortex. Also involved in the differentiation of CD8+ T-cells during immune response regulating the expression of lytic effector genes. .
Accessions	ENST00000449599.4 [O95936-4] ENST00000295743.8 [O95936-1] ENST00000461503.2 [O95936-3] O95936

EOMES report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review