IL19 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of IL19 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of IL19 at tissue level.

III. Associated gene sets

GO_0007165Biological processsignal transduction
GO_0006915Biological processapoptotic process
GO_0006955Biological processimmune response
GO_0010989Biological processnegative regulation of low-density lipoprotein particle clearance
GO_2001237Biological processnegative regulation of extrinsic apoptotic signaling pathway
GO_2001244Biological processpositive regulation of intrinsic apoptotic signaling pathway
GO_0072593Biological processreactive oxygen species metabolic process
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0005125Molecular functioncytokine activity

IV. Literature review

[source]
Gene nameIL19
Protein nameInterleukin-19 (IL-19) (Melanoma differentiation-associated protein-like protein) (NG.1)
SynonymsZMDA1
DescriptionFUNCTION: Cytokine that functions as an anti-inflammatory and proangiogenic factor . Polarizes adaptive immunity to an anti-inflammatory phenotype through induction of T-helper 2 responses by both down-regulation of IFN-gamma and up-regulation of IL4 and IL13 . Produced by osteocytes, stimulates granulopoiesis and neutrophil formation (By similarity). Exerts its biological effect through a receptor complex consisting of a heterodimer of IL20RA and IL20RB . In turn, activates the Janus kinase (JAK) and signal transducer and activator of transcription (STAT) pathway, and importantly, STAT3 . .

AccessionsENST00000656872.2 [Q9UHD0-1]
ENST00000340758.7 [Q9UHD0-1]
ENST00000270218.10 [Q9UHD0-1]
Q9UHD0
ENST00000659997.3 [Q9UHD0-1]