LHX3 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of LHX3 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of LHX3 at tissue level.

III. Associated gene sets

GO_0030324Biological processlung development
GO_0021527Biological processspinal cord association neuron differentiation
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0009887Biological processanimal organ morphogenesis
GO_0048839Biological processinner ear development
GO_0001890Biological processplacenta development
GO_0021520Biological processspinal cord motor neuron cell fate specification
GO_0030182Biological processneuron differentiation
GO_0043066Biological processnegative regulation of apoptotic process
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0060129Biological processthyroid-stimulating hormone-secreting cell differentiation
GO_0021526Biological processmedial motor column neuron differentiation
GO_0021521Biological processventral spinal cord interneuron specification
GO_0006915Biological processapoptotic process
GO_0060126Biological processsomatotropin secreting cell differentiation
GO_0008045Biological processmotor neuron axon guidance
GO_0060127Biological processprolactin secreting cell differentiation
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0000785Cellular componentchromatin
GO_0005667Cellular componenttranscription regulator complex
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000977Molecular functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0043565Molecular functionsequence-specific DNA binding
GO_0061629Molecular functionRNA polymerase II-specific DNA-binding transcription factor binding
GO_0001223Molecular functiontranscription coactivator binding
GO_0008270Molecular functionzinc ion binding

IV. Literature review

[source]
Gene nameLHX3
Protein nameLIM/homeobox protein Lhx3 (LIM homeobox protein 3)
LIM/homeobox protein Lhx3
Lim-homeobox transcription factor LHX3
Synonyms
DescriptionFUNCTION: Transcription factor. Recognizes and binds to the consensus sequence motif 5'-AATTAATTA-3' in the regulatory elements of target genes, such as glycoprotein hormones alpha chain CGA and visual system homeobox CHX10, positively modulating transcription; transcription can be co-activated by LDB2. Synergistically enhances transcription from the prolactin promoter in cooperation with POU1F1/Pit-1 (By similarity). Required for the establishment of the specialized cells of the pituitary gland and the nervous system . Involved in the development of interneurons and motor neurons in cooperation with LDB1 and ISL1 (By similarity). .

AccessionsENST00000371748.10 [Q9UBR4-1]
Q9UBR4
F1T0D8
F1T0D7
F1T0D5
F1T0D9
ENST00000619587.1
Q9HBU2
ENST00000371746.9 [Q9UBR4-2]