ERRFI1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0050673Biological processepithelial cell proliferation
GO_0032355Biological processresponse to estradiol
GO_0048286Biological processlung alveolus development
GO_0072659Biological processprotein localization to plasma membrane
GO_0036022Biological processlimb joint morphogenesis
GO_0042059Biological processnegative regulation of epidermal growth factor receptor signaling pathway
GO_1904565Biological processresponse to 1-oleoyl-sn-glycerol 3-phosphate
GO_0008203Biological processcholesterol metabolic process
GO_0035988Biological processchondrocyte proliferation
GO_0050847Biological processprogesterone receptor signaling pathway
GO_0032868Biological processresponse to insulin
GO_0001889Biological processliver development
GO_0060426Biological processlung vasculature development
GO_0045616Biological processregulation of keratinocyte differentiation
GO_0060613Biological processfat pad development
GO_0043491Biological processphosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0043589Biological processskin morphogenesis
GO_0060428Biological processlung epithelium development
GO_0006915Biological processapoptotic process
GO_0007173Biological processepidermal growth factor receptor signaling pathway
GO_0035847Biological processuterine epithelium development
GO_0010467Biological processgene expression
GO_0006699Biological processbile acid biosynthetic process
GO_0007175Biological processnegative regulation of epidermal growth factor-activated receptor activity
GO_0001894Biological processtissue homeostasis
GO_0009410Biological processresponse to xenobiotic stimulus
GO_0031953Biological processnegative regulation of protein autophosphorylation
GO_0032570Biological processresponse to progesterone
GO_0051216Biological processcartilage development
GO_0016477Biological processcell migration
GO_0006006Biological processglucose metabolic process
GO_0007566Biological processembryo implantation
GO_0042632Biological processcholesterol homeostasis
GO_0005886Cellular componentplasma membrane
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0019901Molecular functionprotein kinase binding
GO_0005096Molecular functionGTPase activator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameERRFI1
Protein nameERBB receptor feedback inhibitor 1
ERBB receptor feedback inhibitor 1 (Mitogen-inducible gene 6 protein) (MIG-6)
SynonymsMIG6
DescriptionFUNCTION: Negative regulator of EGFR signaling in skin morphogenesis. Acts as a negative regulator for several EGFR family members, including ERBB2, ERBB3 and ERBB4. Inhibits EGFR catalytic activity by interfering with its dimerization. Inhibits autophosphorylation of EGFR, ERBB2 and ERBB4. Important for normal keratinocyte proliferation and differentiation. Plays a role in modulating the response to steroid hormones in the uterus. Required for normal response to progesterone in the uterus and for fertility. Mediates epithelial estrogen responses in the uterus by regulating ESR1 levels and activation. Important for regulation of endometrium cell proliferation. Important for normal prenatal and perinatal lung development (By similarity). .

AccessionsK7EJB4
ENST00000467067.1
K7ENN7
I6S2Y9
Q9UJM3
K7ENI4
ENST00000469499.5
K7EMD2
ENST00000487559.1
ENST00000474874.5
ENST00000377482.10