Name | Number of supported studies | Average coverage | |
---|---|---|---|
fibroblast | 23 studies | 31% ± 16% | |
basal cell | 21 studies | 39% ± 14% | |
epithelial cell | 16 studies | 34% ± 17% | |
smooth muscle cell | 13 studies | 24% ± 5% | |
type I pneumocyte | 12 studies | 38% ± 14% | |
type II pneumocyte | 10 studies | 32% ± 9% | |
secretory cell | 9 studies | 30% ± 9% | |
endothelial cell | 7 studies | 31% ± 21% | |
epithelial cell of proximal tubule | 7 studies | 38% ± 15% | |
ciliated cell | 7 studies | 34% ± 18% | |
club cell | 7 studies | 32% ± 10% | |
pericyte | 7 studies | 25% ± 9% | |
hepatocyte | 6 studies | 75% ± 19% | |
connective tissue cell | 6 studies | 33% ± 19% | |
adipocyte | 5 studies | 36% ± 16% | |
astrocyte | 5 studies | 21% ± 4% | |
cholangiocyte | 4 studies | 60% ± 18% | |
abnormal cell | 4 studies | 32% ± 16% | |
mesothelial cell | 4 studies | 23% ± 8% | |
luminal hormone-sensing cell of mammary gland | 4 studies | 45% ± 5% | |
luminal cell of prostate epithelium | 4 studies | 50% ± 10% | |
myofibroblast cell | 4 studies | 26% ± 12% | |
keratinocyte | 4 studies | 32% ± 19% | |
squamous epithelial cell | 3 studies | 34% ± 20% | |
kidney loop of Henle epithelial cell | 3 studies | 20% ± 5% | |
capillary endothelial cell | 3 studies | 18% ± 3% | |
Mueller cell | 3 studies | 19% ± 2% | |
muscle cell | 3 studies | 42% ± 7% | |
GABAergic neuron | 3 studies | 24% ± 4% | |
glutamatergic neuron | 3 studies | 31% ± 6% | |
vein endothelial cell | 3 studies | 24% ± 8% | |
mucus secreting cell | 3 studies | 29% ± 8% | |
myoepithelial cell | 3 studies | 33% ± 4% | |
progenitor cell of mammary luminal epithelium | 3 studies | 34% ± 13% | |
parietal epithelial cell | 3 studies | 50% ± 7% |
Name | Number of supported studies | Average coverage | |
---|---|---|---|
lung | 6 studies | 26% ± 10% | |
kidney | 5 studies | 21% ± 4% | |
prostate | 5 studies | 38% ± 13% | |
liver | 4 studies | 39% ± 12% | |
uterus | 4 studies | 29% ± 6% | |
breast | 4 studies | 28% ± 9% | |
brain | 4 studies | 23% ± 4% | |
eye | 3 studies | 24% ± 6% | |
intestine | 3 studies | 16% ± 1% | |
skin | 3 studies | 21% ± 5% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
pancreas | 97% | 28259.55 | 319 / 328 | 99% | 185.87 | 176 / 178 |
liver | 100% | 35236.85 | 225 / 226 | 95% | 185.45 | 387 / 406 |
bladder | 100% | 10158.43 | 21 / 21 | 90% | 94.08 | 455 / 504 |
breast | 99% | 18313.51 | 455 / 459 | 91% | 72.37 | 1018 / 1118 |
thymus | 98% | 15941.34 | 642 / 653 | 90% | 114.44 | 544 / 605 |
lung | 94% | 11401.89 | 542 / 578 | 94% | 168.90 | 1086 / 1155 |
uterus | 94% | 7357.91 | 159 / 170 | 83% | 75.85 | 380 / 459 |
esophagus | 89% | 21340.75 | 1285 / 1445 | 86% | 71.87 | 158 / 183 |
stomach | 87% | 13938.77 | 312 / 359 | 85% | 52.43 | 244 / 286 |
prostate | 86% | 7253.02 | 211 / 245 | 84% | 58.38 | 424 / 502 |
intestine | 82% | 6916.57 | 789 / 966 | 87% | 60.55 | 457 / 527 |
ovary | 100% | 19506.96 | 180 / 180 | 59% | 30.94 | 254 / 430 |
kidney | 75% | 9054.52 | 67 / 89 | 73% | 133.45 | 661 / 901 |
skin | 97% | 13917.36 | 1759 / 1809 | 38% | 42.97 | 177 / 472 |
ureter | 0% | 0 | 0 / 0 | 100% | 34.82 | 1 / 1 |
blood vessel | 100% | 25223.17 | 1331 / 1335 | 0% | 0 | 0 / 0 |
adipose | 99% | 19539.75 | 1193 / 1204 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 80% | 54.64 | 36 / 45 |
muscle | 70% | 19128.72 | 563 / 803 | 0% | 0 | 0 / 0 |
adrenal gland | 41% | 2096.33 | 105 / 258 | 27% | 22.12 | 63 / 230 |
brain | 19% | 854.90 | 496 / 2642 | 42% | 19.57 | 296 / 705 |
heart | 32% | 2459.96 | 274 / 861 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 10% | 4.37 | 3 / 29 |
spleen | 4% | 184.10 | 9 / 241 | 0% | 0 | 0 / 0 |
peripheral blood | 0% | 22.41 | 3 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0050673 | Biological process | epithelial cell proliferation |
GO_0032355 | Biological process | response to estradiol |
GO_0048286 | Biological process | lung alveolus development |
GO_0072659 | Biological process | protein localization to plasma membrane |
GO_0036022 | Biological process | limb joint morphogenesis |
GO_0042059 | Biological process | negative regulation of epidermal growth factor receptor signaling pathway |
GO_1904565 | Biological process | response to 1-oleoyl-sn-glycerol 3-phosphate |
GO_0008203 | Biological process | cholesterol metabolic process |
GO_0035988 | Biological process | chondrocyte proliferation |
GO_0050847 | Biological process | progesterone receptor signaling pathway |
GO_0032868 | Biological process | response to insulin |
GO_0001889 | Biological process | liver development |
GO_0060426 | Biological process | lung vasculature development |
GO_0045616 | Biological process | regulation of keratinocyte differentiation |
GO_0060613 | Biological process | fat pad development |
GO_0043491 | Biological process | phosphatidylinositol 3-kinase/protein kinase B signal transduction |
GO_0043589 | Biological process | skin morphogenesis |
GO_0060428 | Biological process | lung epithelium development |
GO_0006915 | Biological process | apoptotic process |
GO_0007173 | Biological process | epidermal growth factor receptor signaling pathway |
GO_0035847 | Biological process | uterine epithelium development |
GO_0010467 | Biological process | gene expression |
GO_0006699 | Biological process | bile acid biosynthetic process |
GO_0007175 | Biological process | negative regulation of epidermal growth factor-activated receptor activity |
GO_0001894 | Biological process | tissue homeostasis |
GO_0009410 | Biological process | response to xenobiotic stimulus |
GO_0031953 | Biological process | negative regulation of protein autophosphorylation |
GO_0032570 | Biological process | response to progesterone |
GO_0051216 | Biological process | cartilage development |
GO_0016477 | Biological process | cell migration |
GO_0006006 | Biological process | glucose metabolic process |
GO_0007566 | Biological process | embryo implantation |
GO_0042632 | Biological process | cholesterol homeostasis |
GO_0005886 | Cellular component | plasma membrane |
GO_0005829 | Cellular component | cytosol |
GO_0005737 | Cellular component | cytoplasm |
GO_0005634 | Cellular component | nucleus |
GO_0019901 | Molecular function | protein kinase binding |
GO_0005096 | Molecular function | GTPase activator activity |
GO_0005515 | Molecular function | protein binding |
Gene name | ERRFI1 |
Protein name | ERBB receptor feedback inhibitor 1 ERBB receptor feedback inhibitor 1 (Mitogen-inducible gene 6 protein) (MIG-6) |
Synonyms | MIG6 |
Description | FUNCTION: Negative regulator of EGFR signaling in skin morphogenesis. Acts as a negative regulator for several EGFR family members, including ERBB2, ERBB3 and ERBB4. Inhibits EGFR catalytic activity by interfering with its dimerization. Inhibits autophosphorylation of EGFR, ERBB2 and ERBB4. Important for normal keratinocyte proliferation and differentiation. Plays a role in modulating the response to steroid hormones in the uterus. Required for normal response to progesterone in the uterus and for fertility. Mediates epithelial estrogen responses in the uterus by regulating ESR1 levels and activation. Important for regulation of endometrium cell proliferation. Important for normal prenatal and perinatal lung development (By similarity). . |
Accessions | K7EJB4 ENST00000467067.1 K7ENN7 I6S2Y9 Q9UJM3 K7ENI4 ENST00000469499.5 K7EMD2 ENST00000487559.1 ENST00000474874.5 ENST00000377482.10 |