RBM5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0000398Biological processmRNA splicing, via spliceosome
GO_0006915Biological processapoptotic process
GO_0008285Biological processnegative regulation of cell population proliferation
GO_0000245Biological processspliceosomal complex assembly
GO_0043065Biological processpositive regulation of apoptotic process
GO_0000381Biological processregulation of alternative mRNA splicing, via spliceosome
GO_0006396Biological processRNA processing
GO_0005654Cellular componentnucleoplasm
GO_0005681Cellular componentspliceosomal complex
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0005515Molecular functionprotein binding
GO_0003729Molecular functionmRNA binding
GO_0046872Molecular functionmetal ion binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameRBM5
Protein nameRNA-binding protein 5 (Protein G15) (Putative tumor suppressor LUCA15) (RNA-binding motif protein 5) (Renal carcinoma antigen NY-REN-9)
RNA binding motif protein 5
RNA binding motif protein 5 isoform 1
RNA binding motif protein 5 isoform 2
RNA-binding protein 5 variant
Synonymsvariant
LUCA15
H37
DescriptionFUNCTION: Component of the spliceosome A complex. Regulates alternative splicing of a number of mRNAs. May modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron. May both positively and negatively regulate apoptosis by regulating the alternative splicing of several genes involved in this process, including FAS and CASP2/caspase-2. In the case of FAS, promotes exclusion of exon 6 thereby producing a soluble form of FAS that inhibits apoptosis. In the case of CASP2/caspase-2, promotes exclusion of exon 9 thereby producing a catalytically active form of CASP2/Caspase-2 that induces apoptosis. .

AccessionsENST00000347869.8 [P52756-1]
ENST00000437500.5
ENST00000438369.5
A0A0S2Z5U0
C9J9P7
C9JR02
ENST00000395174.6
H7BYM9
ENST00000469838.5 [P52756-2]
C9JFQ5
ENST00000417905.1
ENST00000404526.6
F8WE23
ENST00000441305.5
A0A0S2Z549
F8W910
E1CJT4
P52756