CIDEC report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CIDEC at tissue level.

III. Associated gene sets

GO_0097194Biological processexecution phase of apoptosis
GO_0006915Biological processapoptotic process
GO_0090209Biological processnegative regulation of triglyceride metabolic process
GO_0120009Biological processintermembrane lipid transfer
GO_0042981Biological processregulation of apoptotic process
GO_0019915Biological processlipid storage
GO_0034389Biological processlipid droplet organization
GO_0050995Biological processnegative regulation of lipid catabolic process
GO_0160077Biological processlipid droplet fusion
GO_0005783Cellular componentendoplasmic reticulum
GO_0005829Cellular componentcytosol
GO_0005811Cellular componentlipid droplet
GO_0005634Cellular componentnucleus
GO_0070300Molecular functionphosphatidic acid binding
GO_0140693Molecular functionmolecular condensate scaffold activity
GO_0005515Molecular functionprotein binding
GO_0120013Molecular functionlipid transfer activity
GO_0003674Molecular functionmolecular_function

IV. Literature review

[source]
Gene nameCIDEC
Protein nameCIDEC protein
Cell death inducing DFFA like effector c
Lipid transferase CIDEC (Cell death activator CIDE-3) (Cell death-inducing DFFA-like effector protein C) (Fat-specific protein FSP27 homolog)
SynonymsFSP27
DescriptionFUNCTION: Lipid transferase specifically expressed in white adipose tissue, which promotes unilocular lipid droplet formation by mediating lipid droplet fusion . Lipid droplet fusion promotes their enlargement, restricting lipolysis and favoring lipid storage . Localizes on the lipid droplet surface, at focal contact sites between lipid droplets, and mediates atypical lipid droplet fusion by undergoing liquid-liquid phase separation (LLPS) and promoting directional net neutral lipid transfer from the smaller to larger lipid droplets . The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair . Its role in neutral lipid transfer and lipid droplet enlargement is activated by the interaction with PLIN1 . May also act as a CEBPB coactivator in the white adipose tissue to control the expression of a subset of CEBPB downstream target genes, including SOCS1, SOCS3, TGFB1, TGFBR1, ID2 and XDH (By similarity). When overexpressed in preadipocytes, induces apoptosis or increases cell susceptibility to apoptosis induced by serum deprivation or TGFB treatment . .

AccessionsENST00000443115.1
ENST00000430427.6 [Q96AQ7-4]
ENST00000336832.7 [Q96AQ7-1]
ENST00000679265.1 [Q96AQ7-1]
ENST00000383817.5
Q86XG0
ENST00000423850.5 [Q96AQ7-2]
A0A0A0MRY9
ENST00000618572.4 [Q96AQ7-4]
A0A0C4DG75
ENST00000675828.1 [Q96AQ7-1]
Q96AQ7
ENST00000455015.6 [Q96AQ7-2]