TRAIP report

I. Expression across cell types

Insufficient scRNA-seq data for expression of TRAIP at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TRAIP at tissue level.

III. Associated gene sets

GO_0007165Biological processsignal transduction
GO_0006915Biological processapoptotic process
GO_0032688Biological processnegative regulation of interferon-beta production
GO_0006974Biological processDNA damage response
GO_0016567Biological processprotein ubiquitination
GO_0031297Biological processreplication fork processing
GO_0010804Biological processnegative regulation of tumor necrosis factor-mediated signaling pathway
GO_0106300Biological processprotein-DNA covalent cross-linking repair
GO_0005730Cellular componentnucleolus
GO_0090734Cellular componentsite of DNA damage
GO_0005654Cellular componentnucleoplasm
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005634Cellular componentnucleus
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameTRAIP
Protein nameTRAF interacting protein
E3 ubiquitin-protein ligase TRAIP (EC 2.3.2.27) (RING finger protein 206) (TRAF-interacting protein)
SynonymsTRIP
RNF206
DescriptionFUNCTION: E3 ubiquitin ligase required to protect genome stability in response to replication stress . Acts as a key regulator of interstrand cross-link repair, which takes place when both strands of duplex DNA are covalently tethered together, thereby blocking replication and transcription (By similarity). Controls the choice between the two pathways of replication-coupled interstrand-cross-link repair by mediating ubiquitination of MCM7 subunit of the CMG helicase complex (By similarity). Short ubiquitin chains on MCM7 promote recruitment of DNA glycosylase NEIL3 (By similarity). If the interstrand cross-link cannot be cleaved by NEIL3, the ubiquitin chains continue to grow on MCM7, promoting the unloading of the CMG helicase complex by the VCP/p97 ATPase, enabling the Fanconi anemia DNA repair pathway (By similarity). Only catalyzes ubiquitination of MCM7 when forks converge (By similarity). Also involved in the repair of covalent DNA-protein cross-links (DPCs) during DNA synthesis: promotes ubiquitination of DPCs, leading to their degradation by the proteasome (By similarity). Has also been proposed to play a role in promoting translesion synthesis by mediating the assembly of 'Lys-63'-linked poly-ubiquitin chains on the Y-family polymerase POLN in order to facilitate bypass of DNA lesions and preserve genomic integrity . The function in translesion synthesis is however controversial . Acts as a regulator of the spindle assembly checkpoint . Also acts as a negative regulator of innate immune signaling by inhibiting activation of NF-kappa-B mediated by TNF . Negatively regulates TLR3/4- and RIG-I-mediated IRF3 activation and subsequent IFNB1 production and cellular antiviral response by promoting 'Lys-48'-linked polyubiquitination of TNK1 leading to its proteasomal degradation . .

AccessionsENST00000331456.7
E7ETV1
ENST00000469027.5
E7EW89
E7EVC4
Q9BWF2
ENST00000482582.5
ENST00000482243.1
ENST00000473195.5
E7EN91