TAX1BP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0045087Biological processinnate immune response
GO_0006915Biological processapoptotic process
GO_0006914Biological processautophagy
GO_0034144Biological processnegative regulation of toll-like receptor 4 signaling pathway
GO_0039532Biological processnegative regulation of cytoplasmic pattern recognition receptor signaling pathway
GO_0043066Biological processnegative regulation of apoptotic process
GO_1905161Biological processprotein localization to phagocytic vesicle
GO_0032088Biological processnegative regulation of NF-kappaB transcription factor activity
GO_0070062Cellular componentextracellular exosome
GO_0005829Cellular componentcytosol
GO_0031410Cellular componentcytoplasmic vesicle
GO_0000407Cellular componentphagophore assembly site
GO_0005776Cellular componentautophagosome
GO_0005739Cellular componentmitochondrion
GO_0019900Molecular functionkinase binding
GO_0030674Molecular functionprotein-macromolecule adaptor activity
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameTAX1BP1
Protein nameTax1-binding protein 1 (TRAF6-binding protein)
Tax1 binding protein 1
Alternative protein TAX1BP1
SynonymsT6BP
PRO0105
DescriptionFUNCTION: Ubiquitin-binding adapter that participates in inflammatory, antiviral and innate immune processes as well as selective autophagy regulation . Plays a key role in the negative regulation of NF-kappa-B and IRF3 signalings by acting as an adapter for the ubiquitin-editing enzyme A20/TNFAIP3 to bind and inactivate its substrates . Disrupts the interactions between the E3 ubiquitin ligase TRAF3 and TBK1/IKBKE to attenuate 'Lys63'-linked polyubiquitination of TBK1 and thereby IFN-beta production . Recruits also A20/TNFAIP3 to ubiquitinated signaling proteins TRAF6 and RIPK1, leading to their deubiquitination and disruption of IL-1 and TNF-induced NF-kappa-B signaling pathways . Inhibits virus-induced apoptosis by inducing the 'Lys-48'-linked polyubiquitination and degradation of MAVS via recruitment of the E3 ligase ITCH, thereby attenuating MAVS-mediated apoptosis signaling . As a macroautophagy/autophagy receptor, facilitates the xenophagic clearance of pathogenic bacteria such as Salmonella typhimurium and Mycobacterium tuberculosis . Upon NBR1 recruitment to the SQSTM1-ubiquitin condensates, acts as the major recruiter of RB1CC1 to these ubiquitin condensates to promote their autophagic degradation . Mediates the autophagic degradation of other substrates including TICAM1 . .

AccessionsENST00000396319.7 [Q86VP1-1]
Q86VP1
ENST00000433216.6 [Q86VP1-4]
ENST00000265393.10 [Q86VP1-2]
ENST00000409980.5
L8E7U3
V9GZ06
ENST00000418691.5
C9JBZ7
B8ZZD4
ENST00000457186.2
C9J7J4
ENST00000543117.5 [Q86VP1-2]
ENST00000416801.6
F8WBU9
ENST00000488564.2
H7C3L5
ENST00000422800.5