TBX2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TBX2 at tissue level.

III. Associated gene sets

GO_0060037Biological processpharyngeal system development
GO_1901211Biological processnegative regulation of cardiac chamber formation
GO_0003151Biological processoutflow tract morphogenesis
GO_0003148Biological processoutflow tract septum morphogenesis
GO_0001708Biological processcell fate specification
GO_0060560Biological processdevelopmental growth involved in morphogenesis
GO_0071549Biological processcellular response to dexamethasone stimulus
GO_0007219Biological processNotch signaling pathway
GO_0048596Biological processembryonic camera-type eye morphogenesis
GO_1902808Biological processpositive regulation of cell cycle G1/S phase transition
GO_0003272Biological processendocardial cushion formation
GO_0060045Biological processpositive regulation of cardiac muscle cell proliferation
GO_0001947Biological processheart looping
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_1901208Biological processnegative regulation of heart looping
GO_0042733Biological processembryonic digit morphogenesis
GO_0060441Biological processepithelial tube branching involved in lung morphogenesis
GO_0008543Biological processfibroblast growth factor receptor signaling pathway
GO_1905222Biological processatrioventricular canal morphogenesis
GO_0003203Biological processendocardial cushion morphogenesis
GO_1905072Biological processcardiac jelly development
GO_0072105Biological processureteric peristalsis
GO_0090103Biological processcochlea morphogenesis
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0007521Biological processmuscle cell fate determination
GO_0043474Biological processpigment metabolic process involved in pigmentation
GO_0060021Biological processroof of mouth development
GO_0022008Biological processneurogenesis
GO_0060596Biological processmammary placode formation
GO_0035050Biological processembryonic heart tube development
GO_0051145Biological processsmooth muscle cell differentiation
GO_0035909Biological processaorta morphogenesis
GO_0060379Biological processcardiac muscle cell myoblast differentiation
GO_0036302Biological processatrioventricular canal development
GO_0060916Biological processmesenchymal cell proliferation involved in lung development
GO_0048738Biological processcardiac muscle tissue development
GO_0006915Biological processapoptotic process
GO_0032526Biological processresponse to retinoic acid
GO_0090398Biological processcellular senescence
GO_0097325Biological processmelanocyte proliferation
GO_0008016Biological processregulation of heart contraction
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_2000773Biological processnegative regulation of cellular senescence
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005737Cellular componentcytoplasm
GO_0000785Cellular componentchromatin
GO_0005667Cellular componenttranscription regulator complex
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0140297Molecular functionDNA-binding transcription factor binding
GO_0001227Molecular functionDNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0043565Molecular functionsequence-specific DNA binding
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0005515Molecular functionprotein binding
GO_0042826Molecular functionhistone deacetylase binding

IV. Literature review

[source]
Gene nameTBX2
Protein nameT-box transcription factor TBX2 (T-box protein 2)
T-box transcription factor 2
Synonyms
DescriptionFUNCTION: Transcription factor which acts as a transcriptional repressor . May also function as a transcriptional activator (By similarity). Binds to the palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence, or a half-site, which are present in the regulatory region of several genes . Required for cardiac atrioventricular canal formation . May cooperate with NKX2.5 to negatively modulate expression of NPPA/ANF in the atrioventricular canal (By similarity). May play a role as a positive regulator of TGFB2 expression, perhaps acting in concert with GATA4 in the developing outflow tract myocardium (By similarity). Plays a role in limb pattern formation . Acts as a transcriptional repressor of ADAM10 gene expression, perhaps in concert with histone deacetylase HDAC1 as cofactor . Involved in branching morphogenesis in both developing lungs and adult mammary glands, via negative modulation of target genes; acting redundantly with TBX3 (By similarity). Required, together with TBX3, to maintain cell proliferation in the embryonic lung mesenchyme; perhaps acting downstream of SHH, BMP and TGFbeta signaling (By similarity). Involved in modulating early inner ear development, acting independently of, and also redundantly with TBX3, in different subregions of the developing ear (By similarity). Acts as a negative regulator of PML function in cellular senescence . Acts as a negative regulator of expression of CDKN1A/p21, IL33 and CCN4; repression of CDKN1A is enhanced in response to UV-induced stress, perhaps as a result of phosphorylation by p38 MAPK (By similarity). Negatively modulates expression of CDKN2A/p14ARF and CDH1/E-cadherin . Plays a role in induction of the epithelial-mesenchymal transition (EMT) . Plays a role in melanocyte proliferation, perhaps via regulation of cyclin CCND1 (By similarity). Involved in melanogenesis, acting via negative modulation of expression of DHICA oxidase/TYRP1 and P protein/OCA2 (By similarity). Involved in regulating retinal pigment epithelium (RPE) cell proliferation, perhaps via negatively modulating transcription of the transcription factor CEBPD . .

AccessionsENST00000240328.4
ENST00000419047.5
Q13207
F8WCM9