WNT7A | OmnibusX

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of WNT7A at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	94%	377.38	2488 / 2642	83%	6.41	585 / 705
lung	95%	328.37	549 / 578	25%	2.53	290 / 1155
spleen	99%	258.91	239 / 241	0%	0	0 / 0
ovary	1%	2.28	1 / 180	83%	34.57	358 / 430
pancreas	2%	1.64	6 / 328	69%	12.14	123 / 178
uterus	8%	24.63	14 / 170	54%	10.39	248 / 459
skin	51%	66.10	919 / 1809	1%	0.06	6 / 472
esophagus	15%	19.04	219 / 1445	31%	2.26	56 / 183
bladder	14%	8.67	3 / 21	31%	4.94	157 / 504
kidney	36%	40.19	32 / 89	4%	0.33	36 / 901
tonsil	0%	0	0 / 0	33%	3.52	15 / 45
peripheral blood	30%	43.80	275 / 929	0%	0	0 / 0
prostate	13%	13.15	33 / 245	0%	0	0 / 502
intestine	1%	0.81	11 / 966	5%	0.42	26 / 527
thymus	1%	0.39	4 / 653	5%	0.21	31 / 605
liver	0%	0	0 / 226	3%	0.56	11 / 406
stomach	0%	0	0 / 359	1%	0.13	4 / 286
adrenal gland	0%	0	0 / 258	1%	0.03	2 / 230
breast	0%	0	0 / 459	1%	0.10	9 / 1118
blood vessel	0%	0.24	3 / 1335	0%	0	0 / 0
adipose	0%	0.21	2 / 1204	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
heart	0%	0	0 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
muscle	0%	0	0 / 803	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0030010	Biological process	establishment of cell polarity
GO_0032355	Biological process	response to estradiol
GO_0036465	Biological process	synaptic vesicle recycling
GO_0001525	Biological process	angiogenesis
GO_0060856	Biological process	establishment of blood-brain barrier
GO_0071560	Biological process	cellular response to transforming growth factor beta stimulus
GO_0060054	Biological process	positive regulation of epithelial cell proliferation involved in wound healing
GO_0099068	Biological process	postsynapse assembly
GO_0021846	Biological process	cell proliferation in forebrain
GO_0051247	Biological process	positive regulation of protein metabolic process
GO_0043627	Biological process	response to estrogen
GO_1905606	Biological process	regulation of presynapse assembly
GO_0007548	Biological process	sex differentiation
GO_0048103	Biological process	somatic stem cell division
GO_0022009	Biological process	central nervous system vasculogenesis
GO_0060997	Biological process	dendritic spine morphogenesis
GO_0046330	Biological process	positive regulation of JNK cascade
GO_0007269	Biological process	neurotransmitter secretion
GO_0010595	Biological process	positive regulation of endothelial cell migration
GO_0010628	Biological process	positive regulation of gene expression
GO_0002062	Biological process	chondrocyte differentiation
GO_0042733	Biological process	embryonic digit morphogenesis
GO_0062009	Biological process	secondary palate development
GO_0061038	Biological process	uterus morphogenesis
GO_0048864	Biological process	stem cell development
GO_1904861	Biological process	excitatory synapse assembly
GO_0035115	Biological process	embryonic forelimb morphogenesis
GO_0035116	Biological process	embryonic hindlimb morphogenesis
GO_0060070	Biological process	canonical Wnt signaling pathway
GO_2000463	Biological process	positive regulation of excitatory postsynaptic potential
GO_0009953	Biological process	dorsal/ventral pattern formation
GO_0070307	Biological process	lens fiber cell development
GO_0007409	Biological process	axonogenesis
GO_0030182	Biological process	neuron differentiation
GO_0045167	Biological process	asymmetric protein localization involved in cell fate determination
GO_0045165	Biological process	cell fate commitment
GO_0045893	Biological process	positive regulation of DNA-templated transcription
GO_0043066	Biological process	negative regulation of apoptotic process
GO_0099054	Biological process	presynapse assembly
GO_0000578	Biological process	embryonic axis specification
GO_0014719	Biological process	skeletal muscle satellite cell activation
GO_0031133	Biological process	regulation of axon diameter
GO_0006915	Biological process	apoptotic process
GO_0060066	Biological process	oviduct development
GO_0060071	Biological process	Wnt signaling pathway, planar cell polarity pathway
GO_1904891	Biological process	positive regulation of excitatory synapse assembly
GO_0021707	Biological process	cerebellar granule cell differentiation
GO_0001502	Biological process	cartilage condensation
GO_1905386	Biological process	positive regulation of protein localization to presynapse
GO_0035313	Biological process	wound healing, spreading of epidermal cells
GO_0051965	Biological process	positive regulation of synapse assembly
GO_2000300	Biological process	regulation of synaptic vesicle exocytosis
GO_0050768	Biological process	negative regulation of neurogenesis
GO_0014834	Biological process	skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0099175	Biological process	regulation of postsynapse organization
GO_0035019	Biological process	somatic stem cell population maintenance
GO_0005615	Cellular component	extracellular space
GO_0098978	Cellular component	glutamatergic synapse
GO_0098793	Cellular component	presynapse
GO_0005576	Cellular component	extracellular region
GO_0098685	Cellular component	Schaffer collateral - CA1 synapse
GO_0005886	Cellular component	plasma membrane
GO_0030666	Cellular component	endocytic vesicle membrane
GO_0005796	Cellular component	Golgi lumen
GO_0070062	Cellular component	extracellular exosome
GO_0031012	Cellular component	extracellular matrix
GO_0009986	Cellular component	cell surface
GO_0005788	Cellular component	endoplasmic reticulum lumen
GO_0048018	Molecular function	receptor ligand activity
GO_0005109	Molecular function	frizzled binding
GO_0005102	Molecular function	signaling receptor binding
GO_0005515	Molecular function	protein binding
GO_0005125	Molecular function	cytokine activity

IV. Literature review

[source]

Gene name	WNT7A
Protein name	Protein Wnt-7a
Synonyms
Description	FUNCTION: Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta-catenin signaling pathway (By similarity). Plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development . Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation . Required for normal, sexually dimorphic development of the Mullerian ducts, and for normal fertility in both sexes (By similarity). Required for normal neural stem cell proliferation in the hippocampus dentate gyrus (By similarity). Required for normal progress through the cell cycle in neural progenitor cells, for self-renewal of neural stem cells, and for normal neuronal differentiation and maturation (By similarity). Promotes formation of synapses via its interaction with FZD5 (By similarity). .
Accessions	O00755 ENST00000285018.5

WNT7A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review