TRAF4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0045087Biological processinnate immune response
GO_0030323Biological processrespiratory tube development
GO_0046330Biological processpositive regulation of JNK cascade
GO_0007165Biological processsignal transduction
GO_0045860Biological processpositive regulation of protein kinase activity
GO_0042981Biological processregulation of apoptotic process
GO_0006915Biological processapoptotic process
GO_0043122Biological processregulation of canonical NF-kappaB signal transduction
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0007585Biological processrespiratory gaseous exchange by respiratory system
GO_0005856Cellular componentcytoskeleton
GO_0005886Cellular componentplasma membrane
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0098802Cellular componentplasma membrane signaling receptor complex
GO_0005654Cellular componentnucleoplasm
GO_0001650Cellular componentfibrillar center
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005923Cellular componentbicellular tight junction
GO_0005634Cellular componentnucleus
GO_0031996Molecular functionthioesterase binding
GO_0016740Molecular functiontransferase activity
GO_0019901Molecular functionprotein kinase binding
GO_0042802Molecular functionidentical protein binding
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0050699Molecular functionWW domain binding
GO_0008270Molecular functionzinc ion binding
GO_0005164Molecular functiontumor necrosis factor receptor binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTRAF4
Protein nameTNF receptor-associated factor
TNF receptor-associated factor 4 (EC 2.3.2.27) (Cysteine-rich domain associated with RING and Traf domains protein 1) (Metastatic lymph node gene 62 protein) (MLN 62) (RING finger protein 83)
TNF receptor associated factor 4
SynonymsCART1
RNF83
MLN62
DescriptionFUNCTION: Adapter protein with E3 ligase activity that is involved in many diverse biological processes including cell proliferation, migration, differentiation, DNA repair, platelet activation or apoptosis . Promotes EGFR-mediated signaling by facilitating the dimerization of EGFR and downstream AKT activation thereby promoting cell proliferation . Ubiquitinates SMURF2 through 'Lys-48'-linked ubiquitin chain leading to SMURF2 degradation through the proteasome and subsequently osteogenic differentiation . Promotes 'Lys-63'-mediated ubiquitination of CHK1 which in turn activates cell cycle arrest and activation of DNA repair . In addition, promotes an atypical 'Lys-29'-linked ubiquitination at the C-terminal end of IRS1 which is crucial for insulin-like growth factor (IGF) signal transduction . Regulates activation of NF-kappa-B in response to signaling through Toll-like receptors. Required for normal skeleton development, and for normal development of the respiratory tract (By similarity). Required for activation of RPS6KB1 in response to TNF signaling. Modulates TRAF6 functions. Inhibits adipogenic differentiation by activating pyruvate kinase PKM activity and subsequently the beta-catenin signaling pathway . .

AccessionsC9JJ10
ENST00000454852.6
ENST00000584944.5
K7EJG7
K7ER49
ENST00000586813.5
ENST00000473421.1
J3QR87
ENST00000478021.1
F6SA91
ENST00000262396.10
A0A0C4DFM9
ENST00000475329.5
ENST00000422344.5
ENST00000444415.7
J9JIG0
ENST00000262395.10 [Q9BUZ4-1]
K7EM06
Q9BUZ4
J3QS94