SQSTM1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0097009Biological processenergy homeostasis
GO_0006366Biological processtranscription by RNA polymerase II
GO_0000425Biological processpexophagy
GO_0010821Biological processregulation of mitochondrion organization
GO_0061635Biological processregulation of protein complex stability
GO_0016236Biological processmacroautophagy
GO_0070342Biological processbrown fat cell proliferation
GO_0035973Biological processaggrephagy
GO_1900273Biological processpositive regulation of long-term synaptic potentiation
GO_0030163Biological processprotein catabolic process
GO_0001659Biological processtemperature homeostasis
GO_0000423Biological processmitophagy
GO_0006914Biological processautophagy
GO_0098780Biological processresponse to mitochondrial depolarisation
GO_0002931Biological processresponse to ischemia
GO_0046578Biological processregulation of Ras protein signal transduction
GO_1905719Biological processprotein localization to perinuclear region of cytoplasm
GO_0010508Biological processpositive regulation of autophagy
GO_0006606Biological processprotein import into nucleus
GO_0007032Biological processendosome organization
GO_0000422Biological processautophagy of mitochondrion
GO_0043122Biological processregulation of canonical NF-kappaB signal transduction
GO_0140694Biological processnon-membrane-bounded organelle assembly
GO_0002376Biological processimmune system process
GO_0110076Biological processnegative regulation of ferroptosis
GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0001934Biological processpositive regulation of protein phosphorylation
GO_0016197Biological processendosomal transport
GO_0043065Biological processpositive regulation of apoptotic process
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0071211Biological processprotein targeting to vacuole involved in autophagy
GO_0034144Biological processnegative regulation of toll-like receptor 4 signaling pathway
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_1903078Biological processpositive regulation of protein localization to plasma membrane
GO_0035556Biological processintracellular signal transduction
GO_0030154Biological processcell differentiation
GO_0006915Biological processapoptotic process
GO_0008104Biological processprotein localization
GO_0031397Biological processnegative regulation of protein ubiquitination
GO_0000932Cellular componentP-body
GO_0016605Cellular componentPML body
GO_0044754Cellular componentautolysosome
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0030017Cellular componentsarcomere
GO_0005770Cellular componentlate endosome
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0044753Cellular componentamphisome
GO_0097225Cellular componentsperm midpiece
GO_0097413Cellular componentLewy body
GO_0005739Cellular componentmitochondrion
GO_0016234Cellular componentinclusion body
GO_0005783Cellular componentendoplasmic reticulum
GO_0043232Cellular componentintracellular non-membrane-bounded organelle
GO_0005776Cellular componentautophagosome
GO_0005737Cellular componentcytoplasm
GO_0005829Cellular componentcytosol
GO_0000407Cellular componentphagophore assembly site
GO_0016235Cellular componentaggresome
GO_0042802Molecular functionidentical protein binding
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0042169Molecular functionSH2 domain binding
GO_0140693Molecular functionmolecular condensate scaffold activity
GO_0008270Molecular functionzinc ion binding
GO_0140311Molecular functionprotein sequestering activity
GO_0140313Molecular functionmolecular sequestering activity
GO_0030971Molecular functionreceptor tyrosine kinase binding
GO_0005080Molecular functionprotein kinase C binding
GO_0038023Molecular functionsignaling receptor activity
GO_0043130Molecular functionubiquitin binding
GO_0019899Molecular functionenzyme binding
GO_0070530Molecular functionK63-linked polyubiquitin modification-dependent protein binding
GO_0030674Molecular functionprotein-macromolecule adaptor activity
GO_0005515Molecular functionprotein binding
GO_0044877Molecular functionprotein-containing complex binding
GO_0019901Molecular functionprotein kinase binding
GO_0035255Molecular functionionotropic glutamate receptor binding
GO_0140036Molecular functionubiquitin-modified protein reader activity

IV. Literature review

[source]
Gene nameSQSTM1
Protein nameSequestosome 1
Sequestosome-1 (EBI3-associated protein of 60 kDa) (EBIAP) (p60) (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62)
SynonymsORCA
OSIL
DescriptionFUNCTION: Molecular adapter required for selective macroautophagy (aggrephagy) by acting as a a bridge between polyubiquitinated proteins and autophagosomes . Promotes the recruitment of ubiquitinated cargo proteins to autophagosomes via multiple domains that bridge proteins and organelles in different steps . SQSTM1 first mediates the assembly and removal of ubiquitinated proteins by undergoing liquid-liquid phase separation upon binding to ubiquitinated proteins via its UBA domain, leading to the formation of insoluble cytoplasmic inclusions, known as p62 bodies . SQSTM1 then interacts with ATG8 family proteins on autophagosomes via its LIR motif, leading to p62 body recruitment to autophagosomes, followed by autophagic clearance of ubiquitinated proteins . SQSTM1 is itself degraded along with its ubiquitinated cargos . Also required to recruit ubiquitinated proteins to PML bodies in the nucleus . Also involved in autophagy of peroxisomes (pexophagy) in response to reactive oxygen species (ROS) by acting as a bridge between ubiquitinated PEX5 receptor and autophagosomes . Acts as an activator of the NFE2L2/NRF2 pathway via interaction with KEAP1: interaction inactivates the BCR(KEAP1) complex by sequestering the complex in inclusion bodies, promoting nuclear accumulation of NFE2L2/NRF2 and subsequent expression of cytoprotective genes . Promotes relocalization of 'Lys-63'-linked ubiquitinated STING1 to autophagosomes . Involved in endosome organization by retaining vesicles in the perinuclear cloud: following ubiquitination by RNF26, attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport . Sequesters tensin TNS2 into cytoplasmic puncta, promoting TNS2 ubiquitination and proteasomal degradation . May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1 . May play a role in titin/TTN downstream signaling in muscle cells . Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). .

AccessionsENST00000514093.5
ENST00000453046.5
C9J6J8
ENST00000626660.1
D6RBF1
ENST00000422245.5
ENST00000360718.5 [Q13501-2]
ENST00000510187.5
ENST00000508284.5
ENST00000504627.1
ENST00000643389.2 [Q13501-1]
ENST00000640444.2 [Q13501-1]
Q13501
C9JRJ8
E9PFW8
E3W990
E7EMC7
ENST00000389805.9 [Q13501-1]