HINT2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
ciliated cell	16 studies	33% ± 15%	Explore
natural killer cell	12 studies	24% ± 10%	Explore
plasmacytoid dendritic cell	12 studies	29% ± 11%	Explore
CD8-positive, alpha-beta T cell	11 studies	24% ± 6%	Explore
plasma cell	9 studies	31% ± 12%	Explore
CD16-positive, CD56-dim natural killer cell, human	8 studies	20% ± 2%	Explore
T cell	8 studies	21% ± 4%	Explore
epithelial cell	8 studies	41% ± 17%	Explore
endothelial cell	8 studies	27% ± 10%	Explore
CD4-positive, alpha-beta T cell	7 studies	24% ± 5%	Explore
regulatory T cell	7 studies	21% ± 3%	Explore
B cell	6 studies	20% ± 7%	Explore
CD16-negative, CD56-bright natural killer cell, human	6 studies	19% ± 3%	Explore
epithelial cell of proximal tubule	6 studies	36% ± 10%	Explore
plasmablast	5 studies	41% ± 21%	Explore
CD4-positive, alpha-beta memory T cell	5 studies	20% ± 2%	Explore
basal cell	5 studies	36% ± 19%	Explore
classical monocyte	5 studies	21% ± 6%	Explore
conventional dendritic cell	5 studies	29% ± 14%	Explore
mature NK T cell	5 studies	17% ± 2%	Explore
kidney loop of Henle epithelial cell	5 studies	40% ± 7%	Explore
macrophage	5 studies	22% ± 8%	Explore
abnormal cell	5 studies	24% ± 7%	Explore
fibroblast	5 studies	27% ± 12%	Explore
goblet cell	5 studies	25% ± 9%	Explore
club cell	4 studies	20% ± 2%	Explore
ionocyte	4 studies	25% ± 8%	Explore
exhausted T cell	4 studies	24% ± 7%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	28% ± 13%	Explore
renal alpha-intercalated cell	4 studies	36% ± 4%	Explore
smooth muscle cell	4 studies	24% ± 3%	Explore
erythroblast	4 studies	34% ± 22%	Explore
pericyte	4 studies	21% ± 3%	Explore
type II pneumocyte	4 studies	27% ± 15%	Explore
type I pneumocyte	4 studies	23% ± 12%	Explore
CD8-positive, alpha-beta memory T cell	3 studies	29% ± 10%	Explore
deuterosomal cell	3 studies	25% ± 6%	Explore
duct epithelial cell	3 studies	24% ± 8%	Explore
secretory cell	3 studies	37% ± 19%	Explore
pancreatic A cell	3 studies	32% ± 11%	Explore
type B pancreatic cell	3 studies	35% ± 14%	Explore
effector memory CD8-positive, alpha-beta T cell	3 studies	20% ± 4%	Explore
hematopoietic precursor cell	3 studies	31% ± 7%	Explore
non-classical monocyte	3 studies	20% ± 4%	Explore
enterocyte	3 studies	22% ± 1%	Explore
effector CD4-positive, alpha-beta T cell	3 studies	21% ± 1%	Explore
effector CD8-positive, alpha-beta T cell	3 studies	22% ± 4%	Explore
dendritic cell	3 studies	41% ± 11%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	21% ± 3%	Explore
enteroendocrine cell	3 studies	30% ± 14%	Explore
transit amplifying cell	3 studies	21% ± 3%	Explore
luminal hormone-sensing cell of mammary gland	3 studies	21% ± 3%	Explore
gamma-delta T cell	3 studies	31% ± 22%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	7 studies	27% ± 15%	Explore
kidney	6 studies	24% ± 7%	Explore
peripheral blood	5 studies	20% ± 4%	Explore
intestine	4 studies	22% ± 6%	Explore
liver	3 studies	39% ± 22%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	940.17	2637 / 2642	6%	0.07	39 / 705
intestine	100%	1041.33	966 / 966	5%	0.06	24 / 527
bladder	100%	788.52	21 / 21	3%	0.04	16 / 504
thymus	100%	1166.62	653 / 653	3%	0.04	19 / 605
breast	100%	1240.90	459 / 459	3%	0.03	28 / 1118
pancreas	100%	892.16	328 / 328	2%	0.03	4 / 178
stomach	100%	1076.21	359 / 359	2%	0.03	6 / 286
uterus	99%	677.59	169 / 170	3%	0.03	12 / 459
kidney	100%	2044.62	89 / 89	1%	0.02	13 / 901
ovary	97%	515.07	175 / 180	4%	0.06	18 / 430
lung	99%	852.73	574 / 578	2%	0.03	18 / 1155
adrenal gland	100%	1926.26	258 / 258	0%	0.01	1 / 230
prostate	100%	977.96	245 / 245	0%	0.00	2 / 502
skin	100%	779.98	1808 / 1809	0%	0.00	2 / 472
adipose	100%	1190.57	1204 / 1204	0%	0	0 / 0
esophagus	100%	778.00	1445 / 1445	0%	0	0 / 183
liver	100%	2216.59	226 / 226	0%	0	0 / 406
spleen	100%	957.50	241 / 241	0%	0	0 / 0
muscle	100%	971.33	801 / 803	0%	0	0 / 0
blood vessel	100%	821.94	1331 / 1335	0%	0	0 / 0
heart	100%	1195.42	857 / 861	0%	0	0 / 0
peripheral blood	78%	457.90	727 / 929	0%	0	0 / 0
tonsil	0%	0	0 / 0	2%	0.02	1 / 45
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0006915	Biological process	apoptotic process
GO_2000757	Biological process	negative regulation of peptidyl-lysine acetylation
GO_0006694	Biological process	steroid biosynthetic process
GO_0016042	Biological process	lipid catabolic process
GO_0005741	Cellular component	mitochondrial outer membrane
GO_0005737	Cellular component	cytoplasm
GO_0005739	Cellular component	mitochondrion
GO_0016787	Molecular function	hydrolase activity
GO_0043530	Molecular function	adenosine 5'-monophosphoramidase activity
GO_0005515	Molecular function	protein binding
GO_0000166	Molecular function	nucleotide binding

IV. Literature review

[source]

Gene name	HINT2
Protein name	Adenosine 5'-monophosphoramidase HINT2 (EC 3.9.1.-) (HINT-3) (HIT-17kDa) (Histidine triad nucleotide-binding protein 2, mitochondrial) (HINT-2) (PKCI-1-related HIT protein)
Synonyms
Description	FUNCTION: Exhibits adenosine 5'-monophosphoramidase activity, hydrolyzing purine nucleotide phosphoramidates with a single phosphate group such as adenosine 5'monophosphoramidate (AMP-NH2) to yield AMP and NH2 . Hydrolyzes adenosine 5'-O-p-nitrophenylphosphoramidate (AMP-pNA) . Hydrolyzes fluorogenic purine nucleoside tryptamine phosphoramidates in vitro . May be involved in steroid biosynthesis . May play a role in apoptosis . .
Accessions	ENST00000259667.6 Q9BX68

HINT2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review